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Note 6 - Stock-based Compensation
3 Months Ended
Mar. 31, 2016
Notes to Financial Statements  
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
6. Stock-based Compensation
 
The following table summarizes stock option activity for employees and non-employees:
 
    Options   Weighted-Average Exercise Price   Weighted-Average Remaining Contractual Term (years)   Aggregate
Intrinsic
Value
                 
Outstanding at December 31, 2015     2,200,369     $ 8.52       7.8     $ 15,705  
Granted     10,000     $ 6.68                  
Exercised     (6,394 )   $ 1.92                  
Outstanding at March 31, 2016     2,203,975     $ 8.53       7.6     $ 4,445  
Exercisable at March 31, 2016     939,661     $ 4.35       5.6     $ 3,657  
Vested or expected to vest at March 31, 2016 (1)     2,021,309     $ 8.22       7.4     $ 4,355  
______________________
(1) Represents the number of vested options at March 31, 2016 plus the number of unvested options expected to vest based on the unvested options outstanding at March 31, 2016.
 
The Company has the following shares reserved for future issuance:
 
    March 31,   December 31,
    2016   2015
         
Stock-based compensation awards     3,073,567       2,419,901  
Employee Stock Purchase Plan     297,359       297,359  
Total     3,370,926       2,717,260