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Note 12 - Quarterly Financial Information (Unaudited, in Thousands, Except Share and Per Share Data) (Tables)
12 Months Ended
Dec. 31, 2015
Notes Tables  
Schedule of Quarterly Financial Information [Table Text Block]
    Three Months Ended
    March 31,
2015
  June 30,
2015
  September 30,
2015
  December 31,
2015
Revenue   $ -     $ -     $ -     $ -  
Operating expenses     4,620       4,981       5,082       6,187  
Net loss attributable to common stockholders     (4,580 )     (5,072 )     (5,383 )     (6,342 )
Net loss per share attributable to common stockholders:                                
Basic and Diluted   $ (0.28 )   $ (0.31 )   $ (0.33 )   $ (0.38 )
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders:                                
Basic and Diluted     16,448,688       16,449,937       16,466,945       16,490,430  
     
    Three Months Ended
    March 31,
2014
  June 30,
2014
  September 30,
2014
  December 31,
2014
Revenue   $ -     $ -     $ 2,948     $ -  
Operating expenses     1,933       2,508       2,814       3,273  
Net (loss) income     (2,831 )     (2,563 )     (5,181 )     7,233  
Net (loss) income attributable to common stockholders - basic     (4,343 )     (4,460 )     (7,458 )     5,938  
Net (loss) income attributable to common stockholders - diluted     (4,343 )     (4,460 )     (7,458 )     5,938  
Net (loss) income per share attributable to common stockholders:                                
Basic   $ (18.09 )   $ (18.55 )   $ (31.00 )   $ 0.52  
Diluted   $ (18.09 )   $ (18.55 )   $ (31.00 )   $ 0.48  
Weighted-average common shares outstanding used in net (loss) income per share attributable to common stockholders:                                
Basic     240,138       240,374       240,610       11,444,807 (a)
Diluted     240,138       240,374       240,610       12,295,431 (a)