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Note 8 - Stock-Based Compensation
9 Months Ended
Sep. 30, 2014
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
8.  
Stock-based compensation

Total stock-based compensation expense is recognized for stock options granted to employees and non-employees and has been reported in the Company’s statements of operations as follows (in thousands):

   
Three Months Ended September 30,
   
Nine Months Ended September 30,
 
   
2014
   
2013
   
2014
   
2013
 
                         
Research and development
  $ 47     $ 14     $ 68     $ 98  
General and administrative
    138       7       166       28  
Total
  $ 185     $ 21     $ 234     $ 126  

The following table summarizes stock option activity for employees and nonemployees:

   
Shares
   
Weighted-Average Exercise Price
   
Weighted-Average Remaining Contractual Term (years)
   
Aggregate Intrinsic Value
 
Outstanding at December 31, 2013
    607,017     $ 2.22       5.2     $ 1,627  
Granted
    527,718     $ 4.92                  
Exercised
    (709 )   $ 1.27                  
Cancelled or forfeited
    -     $ -                  
Outstanding at September 30, 2014
    1,134,026     $ 3.49       6.9     $ 8,716  
Exercisable at September 30, 2014
    581,438     $ 2.38       4.5     $ 5,123  
Vested or expected to vest at September 30, 2014
    1,067,423     $ 3.33       6.8     $ 8,264