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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Operating activities    
Net loss $ (13,382,000) $ (15,470,000)
Reconciliation of net loss to net cash used in operating activities:    
Depreciation 279,000 83,000
Amortization of discount on available-for-sale securities (4,000) (35,000)
Foreign currency remeasurement loss (3,000) (25,000)
Stock-based compensation 977,000 2,647,000
Changes in:    
Prepaid expenses and other assets 1,082,000 589,000
Operating lease right-of-use asset 200,000
Interest receivable 10,000 (3,000)
Accounts payable and accrued expenses (1,465,000) (6,706,000)
Operating lease liability (200,000)
Net cash used in operating activities (12,506,000) (18,920,000)
Investing activities    
Purchases of available-for-sale investments (12,951,000)
Proceeds from maturities of available-for-sale investments 2,500,000 23,990,000
Proceeds from sale of available-for-sale investments 1,999,000
Purchase of property and equipment (16,000) (24,000)
Net cash provided by investing activities 2,484,000 13,014,000
Financing activities    
Proceeds from issuance of common stock, net of issuance costs 2,853,000
Proceeds from issuance of common stock under ESPP 84,000
Net cash provided by financing activities 2,937,000
Effect of exchange rate changes on cash 24,000
Decrease in cash, cash equivalents and restricted cash (10,022,000) (2,945,000)
Cash, cash equivalents and restricted cash, beginning of period 19,393,000 21,192,000
Cash, cash equivalents and restricted cash, end of period $ 9,371,000 $ 18,247,000