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Note 12 - Quarterly Financial Information (Unaudited, in Thousands, Except Share and Per Share Data) (Tables)
 12 Months Ended
Dec. 31, 2018
Notes Tables  
Quarterly Financial Information [Table Text Block]
    Three Months Ended (a)
    March 31,   June 30,   September 30,   December 31,
    2018   2018   2018   2018
Operating expenses   $
6,365
     $
5,000
     $
4,622
     $
5,385
  
Net loss attributable to common stockholders    
(6,081
 )    
(4,879
 )    
(4,510
 )    
(5,259
 )
Net loss per share attributable to common stockholders:                                
Basic and Diluted   $
(0.34
 )   $
(0.28
 )   $
(0.25
 )   $
(0.27
 )
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders:                                
Basic and Diluted    
17,674,729
      
17,674,729
      
17,824,186
      
19,221,292
  
    Three Months Ended (a)
    March 31,   June 30,   September 30,   December 31,
    2017   2017   2017   2017
Operating expenses   $
6,480
     $
5,986
     $
12,306
 
   $
5,590
  
Net loss attributable to common stockholders    
(6,498
 )    
(5,608
 )    
(19,054
)
    
(5,551
 )
Net loss per share attributable to common stockholders:                                
Basic and Diluted   $
(0.39
 )   $
(0.33
 )   $
(1.08
)
   $
(0.33
 )
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders:                                
Basic and Diluted    
16,636,201
      
17,207,672
      
17,619,418
(b)
    
17,619,418