Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the use in this Amendment No. 2 to the Registration Statement on Form S-1 No. 333-230034 of our report dated February 21, 2019 (March 18, 2019 as to Note 15) relating to the financial statements of Precision BioSciences, Inc., appearing in the Prospectus, which is part of this Registration Statement, and to the reference to us under the headings “Experts” in such Prospectus.

/s/ Deloitte & Touche LLP

Raleigh, North Carolina

March 18, 2019