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Note 4 - Stockholders' Equity (Tables)
12 Months Ended
Dec. 31, 2020
Notes Tables  
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
         
    Year Ended December 31,
    2020   2019
         
Research and development costs   $
30,883
    $
200,337
 
General and administrative expenses    
554,108
     
680,452
 
Total   $
584,991
    $
880,789
 
Share-based Payment Arrangement, Option, Activity [Table Text Block]
    Number of Options   Weighted-Average Exercise Price   Weighted-Average Remaining Contractual Life (in years)   Aggregate Intrinsic Value
                 
Outstanding at January 1, 2020    
271,660
    $
61.83
     
7.8
    $
-
 
Granted    
1,686,466
    $
0.62
     
 
    $
-
 
Exercised    
-
     
-
     
 
     
 
 
Forfeited/Expired    
(160,750
)   $
23.82
     
 
     
 
 
Outstanding at December 31, 2020    
1,797,376
    $
7.80
     
9.0
    $
438,650
 
                                 
Exercisable at December 31, 2020    
812,742
    $
16.42
     
8.7
    $
182,771
 
Share-based Payment Arrangement, Option, Exercise Price Range [Table Text Block]
Range of Exercise Prices   Number of Options Outstanding   Weighted-Average Exercise Price   Weighted-Average Remaining Contractual Life (in years)   Aggregate Intrinsic Value
$0.62
 
 
1,686,466
    $
0.62
     
9.3
    $
438,650
 
$5.90 - $8.80
 
 
51,758
    $
6.32
     
8.5
     
-
 
$22.20 - $80.60
 
 
23,326
    $
29.21
     
4.5
     
-
 
$107.40 - $1,102.40
 
 
35,826
    $
333.81
     
1.8
     
-
 
 
 
 
1,797,376
    $
7.80
     
9.0
    $
438,650
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
    Year Ended December 31,
    2020   2019
         
Annual dividend  
 
-
 
 
 
-
 
Expected life (in years)  
4.0
-
5.2
 
4.8
-
5.5
Risk free interest rate  
0.2%
-
0.4%
 
1.8%
-
2.5%
Expected volatility  
110%
-
111%
 
97%
-
115%
Schedule of Share-based Compensation, Warrant Activity [Table Text Block]
Range of Exercise Prices   Number of Warrants Outstanding   Range of Expiration Dates
0.900 -1.2525
 
 
3,233,407
 
 
May 2021 - May 2025
1.700 -3.3838
 
 
1,080,333
 
 
July 2024 - January 2025
6.000 -782.6060
 
 
195,489
 
 
July 2021 - April 2024
 
 
 
4,509,229
 
 
 
Restricted Stock [Member]  
Notes Tables  
Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
    Shares of Restricted Stock   Weighted-Average Grant Date Fair Value
         
Outstanding at January 1, 2020    
7,981
    $
5.95
 
Granted    
-
    $
-
 
Vested    
(3,814
)   $
5.90
 
Forfeited    
(4,167
)   $
6.00
 
Outstanding at December 31, 2020    
-
    $
-
 
Restricted Stock Units (RSUs) [Member]  
Notes Tables  
Share-based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
    Number of RSU's   Weighted-Average Grant Date Fair Value
         
Outstanding at January 1, 2020    
5,467
    $
29.62
 
Granted    
24,000
    $
0.70
 
Exercised and converted to common shares    
(563
)   $
236.20
 
Forfeited    
-
    $
-
 
Outstanding at December 31, 2020    
28,904
    $
1.58
 
                 
Exercisable at December 31, 2020    
22,904
    $
1.81