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Note 5 - Fair Value Measurements (Details Textual)
3 Months Ended 9 Months Ended
Jun. 30, 2021
shares
Sep. 30, 2021
USD ($)
$ / shares
shares
Nov. 08, 2021
shares
Jul. 21, 2021
USD ($)
$ / shares
shares
May 25, 2021
USD ($)
May 20, 2021
$ / shares
shares
Feb. 01, 2021
USD ($)
$ / shares
Dec. 31, 2020
USD ($)
shares
Dec. 16, 2020
USD ($)
Derivative Liability, Noncurrent   $ 9,434,000           $ 1,830,000  
Warrants and Rights Outstanding, Measurement Input       3,900,000          
Common stock, shares issued (in shares) | shares   12,929,911           2,774,501  
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares     644,138            
Liability classified warrants   $ 0              
Maximum [Member]                  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares   $ 4,695.60              
Minimum [Member]                  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares   $ 3.45              
Senior Secured Promissory Note Warrants [Member]                  
Derivative Liability, Noncurrent   $ 1,100,000         $ 1,800,000 $ 1,900,000  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares   $ 3.88              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares   858,892              
Senior Secured Promissory Note Warrants [Member] | Measurement Input, Share Price [Member]                  
Warrants and Rights Outstanding, Measurement Input   2.65         (17.71) 17.71  
Senior Secured Promissory Note Warrants [Member] | Measurement Input, Price Volatility [Member]                  
Warrants and Rights Outstanding, Measurement Input   0.723         0.88 0.87  
Senior Secured Promissory Note Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member]                  
Warrants and Rights Outstanding, Measurement Input   0.98         0.50 0.50  
Senior Secured Promissory Note Warrants [Member] | Measurement Input, Expected Term [Member]                  
Warrants and Rights Outstanding, Measurement Input   4.9         5.8 6  
Senior Secured Promissory Note Warrants [Member] | Measurement Input, Expected Dividend Rate [Member]                  
Warrants and Rights Outstanding, Measurement Input   0         0 0  
Senior Secured Promissory Note Warrants [Member] | Measurement Input, Exercise Price [Member]                  
Warrants and Rights Outstanding, Measurement Input   3.88              
Senior Secured Promissory Note Warrants [Member] | Altium Growth Fund, LP [Member]                  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares             $ 17.71    
Securities Purchase Agreement, Maximum Borrowing Capacity                 $ 5,000,000.0
Securities Purchase Agreement, Aggregate Purchase Price                 3,750,000
Securities Purchase Agreement, Aggregate Purchase Price, Original Issue Discount                 $ 1,250,000
The Equity Warrant [Member]                  
Derivative Liability, Noncurrent       $ 1,700,000 $ 21,900,000        
The Equity Warrant [Member] | Measurement Input, Share Price [Member]                  
Warrants and Rights Outstanding, Measurement Input       3.58 10.15        
The Equity Warrant [Member] | Measurement Input, Price Volatility [Member]                  
Warrants and Rights Outstanding, Measurement Input       99.10 0.91        
The Equity Warrant [Member] | Measurement Input, Risk Free Interest Rate [Member]                  
Warrants and Rights Outstanding, Measurement Input       0.82 0.01        
The Equity Warrant [Member] | Measurement Input, Expected Term [Member]                  
Warrants and Rights Outstanding, Measurement Input       5.5 5.6        
The Equity Warrant [Member] | Measurement Input, Expected Dividend Rate [Member]                  
Warrants and Rights Outstanding, Measurement Input       0 0        
The Equity Warrant [Member] | Altium Growth Fund, LP [Member]                  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares   $ 3.88       $ 4.70      
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares   5,303,568       4,995,893      
May 2021 Warrants [Member]                  
Derivative Liability, Noncurrent   $ 7,100,000              
May 2021 Warrants [Member] | Measurement Input, Share Price [Member]                  
Warrants and Rights Outstanding, Measurement Input   2.65              
May 2021 Warrants [Member] | Measurement Input, Price Volatility [Member]                  
Warrants and Rights Outstanding, Measurement Input   0.723              
May 2021 Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member]                  
Warrants and Rights Outstanding, Measurement Input   0.98              
May 2021 Warrants [Member] | Measurement Input, Expected Term [Member]                  
Warrants and Rights Outstanding, Measurement Input   4.9              
May 2021 Warrants [Member] | Measurement Input, Expected Dividend Rate [Member]                  
Warrants and Rights Outstanding, Measurement Input   0              
May 2021 Warrants [Member] | Measurement Input, Exercise Price [Member]                  
Warrants and Rights Outstanding, Measurement Input   3.88              
July 2021 Warrants [Member]                  
Derivative Liability, Noncurrent   $ 1,200,000              
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares       $ 3.631          
July 2021 Warrants [Member] | Measurement Input, Share Price [Member]                  
Warrants and Rights Outstanding, Measurement Input   2.74              
July 2021 Warrants [Member] | Measurement Input, Price Volatility [Member]                  
Warrants and Rights Outstanding, Measurement Input   95.20              
July 2021 Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member]                  
Warrants and Rights Outstanding, Measurement Input   1.03              
July 2021 Warrants [Member] | Measurement Input, Expected Term [Member]                  
Warrants and Rights Outstanding, Measurement Input   5.3              
July 2021 Warrants [Member] | Measurement Input, Expected Dividend Rate [Member]                  
Warrants and Rights Outstanding, Measurement Input   0              
July 2021 Warrants [Member] | Maximum [Member]                  
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares) | shares       1,100,000          
Warrants Issued in Connection with May 2016 and August 2017 Offerings [Member]                  
Class of Warrant or Right, Put Feature Settled (in shares) | shares 7,813                
Warrants Associated with the October 2018 Offering [Member]                  
Class of Warrant or Right, Put Feature Settled (in shares) | shares 12,500