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Investments - Narrative (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2021
Apr. 30, 2020
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Variable Interest Entity [Line Items]              
Cash received from sale of subsidiary $ 12,900            
Equity method investment, realized gain (loss) on disposal     $ 12,900   $ 12,888 $ 0 $ 0
Research and development         74,552 $ 90,467 $ 75,961
Variable Interest Entity, Not Primary Beneficiary              
Variable Interest Entity [Line Items]              
Research and development       $ 15,000      
Navitor Pharmaceuticals, Inc.              
Variable Interest Entity [Line Items]              
Agreement termination notice period   30 days          
Threshold for development costs payments   $ 50,000          
Navitor Pharmaceuticals, Inc. | Variable Interest Entity, Not Primary Beneficiary              
Variable Interest Entity [Line Items]              
Investments         $ 15,000    
VIE, qualitative or quantitative information, ownership percentage   13.00%