Item 13(b)

EX-99.906CERT

Certification Pursuant to Rule 30a-2(b) under the 1940 Act and Section 906 of the Sarbanes-Oxley Act

I, James Dondero, President and Principal Executive Officer of NexPoint Strategic Opportunities Fund (the “Registrant”), certify that:

1. The Form N-CSR of the Registrant (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

By:	/s/ James Dondero
	James Dondero
	President and Principal Executive Officer

Date: April 25, 2018

I, Frank Waterhouse, Treasurer, Principal Accounting Officer and Principal Financial Officer of NexPoint Strategic Opportunities Fund (the “Registrant”), certify that:

1. The Form N-CSR of the Registrant (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

By:	/s/ Frank Waterhouse
	Frank Waterhouse
	Treasurer, Principal Accounting Officer
	and Principal Financial Officer

Date: April 25, 2018