Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Cash flows from operating activities
Net income	$ 25,804	$ 3,249
Adjustments to reconcile net income to net cash provided by (used in) operating activities:
Depreciation and amortization	3,549	1,805
Loss on disposal of property, plant and equipment	92	7
Unrealized appreciation on equity securities	(115,454)	(21,922)
Amortization of discount/premium on investments	124	414
Equity in net loss of affiliates	1,956	536
Stock-based compensation expense	10,259	3,774
Contribution of services by shareholder	0	470
Shares issued to nonemployee members of the Board of Directors	480	426
Shares issued as consideration for license agreement	59,579	0
Provision for bad debts	393	0
Deferred income taxes	795	0
Other noncash items	264	35
Receivables:
Trade	(815)	92
Related parties	2,807	(759)
Note	(16)	0
Other	67	(104)
Inventory	(382)	0
Prepaid expenses and other	(292)	2
Other assets	(1,216)	37
Accounts payable	672	516
Accrued compensation and benefits	(297)	(2,480)
Other accrued liabilities	1,210	234
Deferred revenue	(2,621)	23,184
Related party payables	(156)	(47)
Other long term liabilities	157	10
Net cash provided by (used in) operating activities	(13,041)	9,479
Cash flows from investing activities
Maturities of investments	24,000	35,249
Purchases of equity securities and warrants	(14,900)	0
Acquisitions of businesses, net of cash received	(29,559)	(4,912)
Acquisition of noncontrolling interest	(1,566)	0
Investments in affiliates	(1,491)	(1,500)
Purchases of property, plant and equipment	(2,711)	(2,982)
Proceeds from sale of property, plant and equipment	194	0
Net cash provided by (used in) investing activities	(26,033)	25,855
Cash flows from financing activities
Proceeds from issuance of shares in a private placement	0	25,000
Proceeds from issuance of shares in a public offering, net of issuance costs	110,041	0
Advances from lines of credit	5,559	0
Repayments of advances from lines of credit	(7,211)	0
Payments of capital lease obligations	(6)	(8)
Proceeds from long term debt	44	148
Payments of long term debt	(335)	0
Proceeds from stock option exercises	2,567	330
Payment of stock issuance costs	0	(256)
Net cash provided by financing activities	110,659	25,214
Effect of exchange rate changes on cash and cash equivalents	(36)	(5)
Net increase in cash and cash equivalents	71,549	60,543
Cash and cash equivalents
Beginning of period	27,466	49,509
End of period	99,015	110,052
Supplemental disclosure of cash flow information
Cash paid during the period for interest	84	13
Significant noncash financing and investing activities
Stock received as consideration for collaboration agreements	0	5,225
Stock issued in acquisitions, net	39,735	19,368
Stock issued to acquire noncontrolling interest	$ 9,412	$ 0