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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
9 Months Ended
Sep. 30, 2014
Sep. 30, 2013
Cash flows from operating activities    
Net loss $ (103,548) $ (27,890)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 6,870 5,461
Loss on disposal of property, plant and equipment 170 349
Unrealized (appreciation) depreciation on equity securities 48,944 (5,704)
Amortization of discount/premium on investments 1,121 251
Equity in net loss of affiliates 3,510 390
Gain on previously held equity investment 0 (7,415)
Stock-based compensation expense 14,872 1,841
Contribution of services by shareholder 1,485 1,163
Shares issued to nonemployee members of the Board of Directors 486 100
Provision for bad debts 74 0
Other noncash items 244 0
Receivables:    
Trade 3,443 (49)
Related parties (5,168) (4,207)
Other (41) (572)
Inventory 582 0
Prepaid expenses and other (679) (628)
Other assets 89 (58)
Accounts payable (1,197) 182
Accrued compensation and benefits 545 (167)
Other accrued liabilities (820) (300)
Deferred revenue 18,636 (6,091)
Related party payables (192) 35
Other long term liabilities (234) (150)
Net cash used in operating activities (10,808) (43,459)
Cash flows from investing activities    
Purchases of investments (60,478) (233,232)
Maturities of investments 98,245 15,498
Purchases of equity securities 0 (3,900)
Acquisitions of businesses, net of cash received (67,117) 512
Investments in affiliates (2,105) 0
Purchases of property, plant and equipment (5,190) (1,262)
Proceeds from sale of property, plant and equipment 151 480
Issuance of related party note receivable 0 (300)
Proceeds from related party notes receivable 0 500
Net cash used in investing activities (36,494) (221,704)
Cash flows from financing activities    
Proceeds from issuance of Series F redeemable convertible preferred shares 0 150,000
Proceeds from IPO, net of issuance costs 0 168,801
Proceeds from issuance of shares in a private placement 25,000 0
Settlement of fractional shares 0 (5)
Advances from lines of credit 678 0
Repayments of advances from lines of credit (4,213) 0
Payments of capital lease obligations (26) (42)
Proceeds from long term debt 268 354
Payments of long term debt (130) (36)
Proceeds from stock option exercises 1,274 55
Payment of stock issuance costs (256) (3,148)
Net cash provided by financing activities 22,595 315,979
Effect of exchange rate changes on cash and cash equivalents (98) 3
Net increase (decrease) in cash and cash equivalents (24,805) 50,819
Cash and cash equivalents    
Beginning of period 49,509 10,403
End of period 24,704 61,222
Supplemental disclosure of cash flow information    
Cash paid during the period for interest 47 50
Significant noncash financing and investing activities    
Accretion of dividends on redeemable convertible preferred shares 0 18,391
Conversion of redeemable convertible preferred shares to common stock, including accrued dividends 0 571,898
Note receivable as consideration for upfront fee from collaborator 10,000 0
Stock received as consideration for collaboration agreements 5,225 14,847
Stock issued in acquisitions, net 51,682 0
Deferred consideration payable related to acquisition 20,115 0
Accrued contribution to affiliate $ 0 $ 5,000