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Stock Options and Warrants - Summary of Changes in Options Outstanding and Related Exercise Prices for Shares of Company's Common Stock Options Issued (Detail) - USD ($)
$ / shares in Units, $ in Thousands
2 Months Ended 12 Months Ended
Dec. 31, 2009
Dec. 31, 2017
Dec. 31, 2016
2006 Plan and 2010 Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Number of Options, Outstanding, Beginning balance   1,460,076 200,909
Number of Options, Granted   1,145,568 1,346,800
Number of Options, Canceled or expired   (360,295) (87,633)
Number of Options, Outstanding, Ending balance   2,245,349 1,460,076
Number of Options, Options vested and expected to vest Ending Balance   2,105,101  
Number of Options, Options exercisable Ending Balance   960,860  
Weighted Average Exercise Price Per Share, Outstanding, Beginning balance   $ 13.21 $ 83.10
Weighted Average Exercise Price Per Share, Granted   1.14 3.41
Weighted Average Exercise Price Per Share, Canceled or expired   5.80 22.80
Weighted Average Exercise Price Per Share, Outstanding, Ending balance   8.25 $ 13.21
Weighted Average Exercise Price, Options vested or expected to vest Ending Balance   8.65  
Weighted Average Exercise Price, Options exercisable Ending Balance   $ 16.36  
Weighted Average Remaining Contractual Term, Options Outstanding Ending Balance   8 years 6 months 10 days  
Weighted Average Remaining Contractual Term, Options vested or expected to vest Ending Balance   8 years 6 months 3 days  
Weighted Average Remaining Contractual Term, Options exercisable Ending Balance   8 years 1 month 6 days  
Aggregate Intrinsic Value, Options outstanding, Ending balance   $ 451,224  
Aggregate Intrinsic Value, Options vested or expected to vest Ending Balance   416,005  
Aggregate Intrinsic Value, Options exercisable Ending Balance   $ 109,161  
Outside Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Number of Options, Outstanding, Beginning balance   50,730 50,730
Number of Options, Granted 68,384    
Number of Options, Outstanding, Ending balance   50,730 50,730
Weighted Average Exercise Price Per Share, Outstanding, Beginning balance   $ 92.31 $ 92.31
Weighted Average Exercise Price Per Share, Outstanding, Ending balance   $ 92.31 $ 92.31
Weighted Average Remaining Contractual Term, Options exercisable Ending Balance   1 year 10 months 10 days