Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statement on Form S-8 pertaining to the Alphatec Holdings, Inc. 2016 Employment Inducement Award Plan, 2016 Equity Incentive Plan, and 2007 Employee Stock Purchase Plan of our report dated March 29, 2019, with respect to the consolidated financial statements of Alphatec Holdings, Inc. included in its Annual Report on Form 10-K for the year ended December 31, 2018, filed with the Securities and Exchange Commission.

/s/ Mayer Hoffman McCann P.C.

San Diego, California

July 15, 2019

                       Member of Kreston International — a global network of independent accounting firms