CONSOLIDATED STATEMENTS OF STOCKHOLDERS' (DEFICIT) EQUITY - USD ($) shares in Thousands, $ in Thousands	Total	Phygen, LLC [Member]	Common Stock [Member]	Common Stock [Member] Phygen, LLC [Member]	Additional paid-in capital [Member]	Additional paid-in capital [Member] Phygen, LLC [Member]	Shareholder note receivable [Member]	Treasury stock [Member]	Accumulated other comprehensive income (loss) [Member]	Accumulated deficit [Member]
Balance beginning, value at Dec. 31, 2012	$ 245,816		$ 10		$ 399,246			$ (97)	$ 112	$ (153,455)
Balance beginning, shares at Dec. 31, 2012			96,703
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	2,590				2,590
Exercise of stock options	8				8
Exercise of stock options, shares			6
Repurchase and/or forfeiture of common stock	(172)				(172)
Repurchase and/or forfeiture of common stock, shares			(142)
Shares issued for consulting services	1,488				1,488
Shares issued for consulting services, shares			354
Issuance of common stock in connection with license agreements	250				250
Issuance of common stock in connection with license agreements, shares			130
Forfeiture of common stock in connection with business acquisition		$ (561)		$ 0		$ (561)
Forfeiture of common stock in connection with business acquisition, shares				(328)
Issuance of common stock for employee stock purchase plan	719				719
Issuance of common stock for employee stock purchase plan, shares			500
Issuance of common stock for restricted share awards granted to employees, shares			376
Foreign currency translation adjustments	3,765								3,765
Net loss	(82,227)									(82,227)
Balance ending, value at Dec. 31, 2013	171,676		$ 10		403,568			(97)	3,877	(235,682)
Balance ending, shares at Dec. 31, 2013			97,599
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	2,690				2,690
Exercise of stock options	29				29
Exercise of stock options, shares			21
Repurchase and/or forfeiture of common stock	(3)				(3)
Repurchase and/or forfeiture of common stock, shares			(266)
Shares issued for consulting services	1,864				1,864
Shares issued for consulting services, shares			1,327
Issuance of common stock for employee stock purchase plan	671				671
Issuance of common stock for employee stock purchase plan, shares			608
Issuance of common stock for restricted share awards granted to employees, shares			493
Shareholder note receivable	0				5,000		$ (5,000)
Issuance of common stock for acquired technology	102				102
Issuance of common stock for acquired technology, shares			74
Foreign currency translation adjustments	(15,193)								(15,193)
Net loss	(12,882)									(12,882)
Balance ending, value at Dec. 31, 2014	148,954		$ 10		413,921		(5,000)	(97)	(11,316)	(248,564)
Balance ending, shares at Dec. 31, 2014			99,856
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	2,562				2,562
Exercise of stock options	$ 0				0
Exercise of stock options, shares	5		5
Repurchase and/or forfeiture of common stock	$ 0				0
Repurchase and/or forfeiture of common stock, shares			(261)
Shares issued for consulting services	81				81
Shares issued for consulting services, shares			1,325
Issuance of common stock for employee stock purchase plan	375				375
Issuance of common stock for employee stock purchase plan, shares			868
Issuance of common stock for restricted share awards granted to employees, shares			292
Issuance of common stock for acquired technology	0				0
Issuance of common stock for acquired technology, shares			73
Foreign currency translation adjustments	(9,872)								(9,872)
Net loss	(178,676)									(178,676)
Balance ending, value at Dec. 31, 2015	$ (36,576)		$ 10		$ 416,939		$ (5,000)	$ (97)	$ (21,188)	$ (427,240)
Balance ending, shares at Dec. 31, 2015			102,158