EXHIBIT 10.1

Invibio^®

biomedical solutions

Invibio LTD

Technology Centre Hillhouse International

Thornton Cleveleys. Lancashire FY5 4QD UK

Tel. +44 (0)1253 866812 Tel +44 (0)1253 851458

info@invibio.com                         www.invibio.com

22^nd August 2014

LDR Medical

Technopole de L'Aube

BP 2-10 902

Troyes cedex 9

France

Dear Sirs,

Letter of Amendment in respect of Supply Agreement between Invibio Ltd. and LDR Medical dated January 31 2003 and subsequent Amendments (the "Agreement").

Following our discussions we are writing to confirm that pursuant to section 27.1 of the Agreement we have agreed to make the following amendment to the Agreement:

1. Clause 3 of the Agreement shall be amended such that the Term of the Agreement shall be extended until the 1^st of October 2014 inclusive.

All capitalized terms used in this Letter shall have the same meaning as when used in the Agreement.

This letter and all matters arising from or connected with it are governed by English Law.

Except as expressly provided in this letter of amendment, all other terms, conditions, and provisions of the Agreement shall continue in full force and effect as provided therein.

/s/ Jonathan Parr	/s/ Eric Vigneron
An authorised signatory for and on behalf of Invibio, Ltd.	An authorised signatory for and on behalf of LDR Medical
Name: Jonathan Parr	Name: Eric Vigneron
Position: Financial Controller	Position: Deputy General Manager
Date: August 27, 2014	Date: August 27, 2014