SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER

PURSUANT TO RULE 13a-16 OR 15d-16 OF THE

SECURITIES EXCHANGE ACT OF 1934

October 28, 2008

Commission File Number: 333-130901

MACRO BANK INC.

(Exact name of registrant as specified in its Charter)

Sarmiento 447

Buenos Aires C1 1041

Tel: 54 11 5222 6500

(Address of registrant’s principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F x Form 40-F o

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):

Yes o No x

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):

Yes o No x

Indicate by check mark whether by furnishing the information contained in this Form, the registrant is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes o No x

If “Yes” is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b): 82- N/A

City of Buenos Aires, October 28, 2008

To the

Comisión Nacional de Valores

25 de mayo 175, 3er. Piso

City of Buenos Aires

Re.: Banco Macro S.A. Reports Relevant Event in Compliance with Section 2, Chapter XXI of Book 6 of the Rules of the Comisión Nacional de Valores.

Dear Sirs,

In my capacity as attorney-in-fact of Banco Macro S.A. (the "Bank") I hereby inform the Comisión Nacional de Valores (the “CNV”) that on October 22, 2008 the Board of Directors of the Bank has decided to (a) cancel (i) an amount of U$S 13,225,000 of its 8.50% Notes Due 2017, Series 2, and (ii) an amount of U$S 1,500,000 of its 10.750% Notes Due 2012, Series 3, both of them issued under its global medium-term note program for an aggregate principal amount at any time outstanding of U$S 700,000,000 and (b) to authorize to request that the authorized listed amount of the Series 2 and Series 3 Notes be reduced.

Sincerely,


		/s/ Luis Cerolini
		Luis Cerolini
		Director

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereto duly authorized.

Date: October 28, 2008
	MACRO BANK INC.

	By:	/s/
		Name: Luis Cerolini
		Title: Director