Commitments and Contingencies - CFTR Activators and Inhibitors - Additional Information (Details) - CFTR Activators and Inhibitors - USD ($) $ in Millions	6 Months Ended	76 Months Ended
	Jun. 30, 2023	Jun. 30, 2023
Commitments and Contingencies [Line Items]
Future percentage of royalty payments based net sales	single-digit
Development and milestone obligations paid to third party		$ 1.6
Developmental Milestone
Commitments and Contingencies [Line Items]
Possible future milestone payments	$ 11.9
Future Regulatory Approval and Sales Milestones
Commitments and Contingencies [Line Items]
Possible future milestone payments	33.0
Development and Milestone Payment, Conclusion of Clinical Studies
Commitments and Contingencies [Line Items]
Possible future milestone payments	1.1
Development and Milestone Payment, Conclusion of Clinical Studies | Maximum
Commitments and Contingencies [Line Items]
Possible future milestone payments	$ 3.2