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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (26,261,549) $ (47,666,208)
Adjustments to reconcile net loss to net cash used in operating activities:    
Acquired in-process research and development   6,500,602
Deferred taxes   (1,309,973)
Stock-based compensation 5,453,520 6,133,990
Non-cash interest expense 424,516 59,766
Accretion on debt securities available for sale, net (91,231) (474,771)
Depreciation and amortization expense 217,806 72,284
Change in assets and liabilities:    
Prepaid expenses and other current assets (212,823) 404,264
Accounts payable (684,402) (3,082,081)
Accrued expenses (8,022,095) 5,604,224
Net cash used in operating activities (29,176,258) (33,757,903)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Acquisitions of fixed assets   (9,529)
Purchases of marketable securities (5,776,090) (36,860,554)
Sales and maturities of marketable securities 34,800,000 59,000,000
Net cash provided by investing activities 29,023,910 22,762,007
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from issuance of common stock, net of issuance costs 40,716,543 720,964
Proceeds from exercise of stock options 1,058,516  
Proceeds from employee stock purchase plan 126,966 194,849
Proceeds from long-term debt   14,450,000
Debt issuance costs paid in cash   (123,186)
Net cash provided by financing activities 41,902,025 15,242,627
NET INCREASE IN CASH AND CASH EQUIVALENTS 41,749,677 4,246,731
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD 44,425,830 47,357,472
CASH AND CASH EQUIVALENTS, END OF PERIOD 86,175,507 51,604,203
Helio Vision Inc    
Adjustments to reconcile net loss to net cash used in operating activities:    
Acquired in-process research and development 6,500,000  
CASH FLOWS FROM INVESTING ACTIVITIES:    
Cash acquired in Helio asset acquisition   632,090
SUPPLEMENTAL INFORMATION AND DISCLOSURES OF NONCASH ACTIVITIES:    
Assets acquired   75,632
Liabilities acquired   637,994
Fair value of securities issued   4,862,731
Right-of-use assets acquired through operating leases   $ 386,060
Cash paid during the period for interest $ 1,042,708