Helio vision acquisition - Additional Information (Detail) - USD ($)		1 Months Ended	3 Months Ended	12 Months Ended
	Jan. 28, 2019	Jan. 31, 2021	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2018
Business Acquisition [Line Items]
Share-based compensation award, vesting period						4 years
Allocated Share Based Compensation Expense				$ 7,108,027	$ 7,083,810
Income tax benefit				0	(479,265)
Acquired in-process research and development				0	1,754,265
Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Business combination, stock issued	1,160,444	246,562
Contingent consideration payable in stock					2,500,000
Income tax benefit					500,000
Common Stock after FDA Approval prior to 10th Anniversary [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Business Combination Contingent Consideration Liability	$ 10,000,000.0
Common Stock after FDA Approval Prior to 12th Anniversary [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Business Combination Contingent Consideration Liability	$ 2,500,000
Common Stock after FDA Approval Prior to 12th Anniversary [Member] | Maximum [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Business combination, contingent consideration stock to be issued	5,248,885
Tax Gross-up Payment in Event of Change of Control or Divesture [Member] | Maximum [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Business Combination Contingent Consideration Liability	$ 1,000,000.0
Research and Development Expenses [Member]
Business Acquisition [Line Items]
Allocated Share Based Compensation Expense				3,562,181	3,798,141
Founders [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Business combination, stock issued	568,627
Founders [Member] | Service Based Awards [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Share-based compensation award, vesting period	3 years
Vesting Percentage Of Shares Of Common Stock Issued Former Security Holders And Advisor	98.00%
Founders [Member] | Restricted Stock [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Share-based compensation award, vesting period	3 years
Founders [Member] | Restricted Stock [Member] | Research and Development Expenses [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Allocated Share Based Compensation Expense				$ 1,200,000	1,300,000
Non Founders [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Business combination, stock issued	591,817
Milestone [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Business combination, stock issued			246,562
Milestone [Member] | Restricted Stock [Member] | Research and Development Expenses [Member] | Helio Vision, Inc [Member]
Business Acquisition [Line Items]
Allocated Share Based Compensation Expense					1,200,000
Expense related to the Milestone IPR&D					$ 1,800,000