10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

Form 10-Q

(Mark One)

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended March 31, 2019

or

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                    to                   

Commission File Number: 001-35420

ChemoCentryx, Inc.

(Exact Name of Registrant as Specified in its Charter)

Delaware	94-3254365
(State or Other Jurisdiction of Incorporation or Organization)	(I.R.S. Employer Identification No.)
850 Maude Avenue Mountain View, California	94043
(Address of Principal Executive Offices)	(Zip Code)

(650) 210-2900

(Registrant’s Telephone Number, Including Area Code)

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes   ☒     No  ☐

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    ☒   Yes    ☐   No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or emerging growth company. See definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☒
Non-accelerated filer	☐	Smaller reporting company	☐
		Emerging growth company	☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 (a) of the Exchange Act.   ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes   ☐    No   ☒

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, par value $0.001 per share	CCXI	The Nasdaq Stock Market LLC

The number of outstanding shares of the registrant’s common stock, par value $0.001 per share, as of April 30, 2019 was 58,047,961.

CHEMOCENTRYX, INC.

QUARTERLY REPORT ON FORM 10-Q

For the quarterly period ended March 31, 2019

Table of Contents

PART I. FINANCIAL INFORMATION		Page
Item 1.	Financial Statements (Unaudited)
	Condensed Consolidated Balance Sheets – March 31, 2019 and December 31, 2018	3
	Condensed Consolidated Statements of Operations – Three Months Ended March 31, 2019 and 2018	4
	Condensed Consolidated Statements of Comprehensive Loss – Three Months Ended March 31, 2019 and 2018	5
	Condensed Consolidated Statements of Stockholders’ Equity – Three Months Ended March 31, 2019 and 2018	6
	Condensed Consolidated Statements of Cash Flows – Three Months Ended March 31, 2019 and 2018	7
	Notes to Condensed Consolidated Financial Statements	8
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	19
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	26
Item 4.	Controls and Procedures	26
PART II. OTHER INFORMATION
Item 1.	Legal Proceedings	27
Item 1A.	Risk Factors	27
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	27
Item 3.	Defaults Upon Senior Securities	27
Item 4.	Mine Safety Disclosures	27
Item 5.	Other Information	27
Item 6.	Exhibits	27
EXHIBIT INDEX		28
SIGNATURES		29

PART I. FINANCIAL INFORMATION

Item 1. Financial Statements

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(in thousands, except share and par value data)

(unaudited)

	March 31, 2019			December 31, 2018
Assets
Current assets:
Cash and cash equivalents	$	79,333		$	28,088
Short-term investments		142,777			148,896
Accounts receivable from related party		167			2,058
Prepaid expenses and other current assets		4,399			2,342
Total current assets		226,676			181,384
Property and equipment, net		1,441			1,536
Long-term investments		11,968			—
Operating lease right-of-use assets		1,062			—
Other assets		210			390
Total assets	$	241,357		$	183,310
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable	$	1,293		$	966
Accrued and other current liabilities		12,865			12,969
Deferred revenue from related party		51,950			50,461
Total current liabilities		66,108			64,396
Long-term debt, net		19,714			19,689
Noncurrent deferred revenue from related party		74,451			84,100
Other non-current liabilities		445			387
Total liabilities		160,718			168,572
Commitments
Stockholders’ equity:
Preferred stock, $0.001 par value, 10,000,000 shares authorized; no shares issued and outstanding		—			—
Common stock, $0.001 par value, 200,000,000 shares authorized; 57,725,915 and 50,652,238 shares issued and outstanding at March 31, 2019 and December 31, 2018, respectively		58			51
Additional paid-in capital		467,047			389,398
Note receivable		(16	)		(16	)
Accumulated other comprehensive loss		(4	)		(198	)
Accumulated deficit		(386,446	)		(374,497	)
Total stockholders’ equity		80,639			14,738
Total liabilities and stockholders’ equity	$	241,357		$	183,310

See accompanying notes.

3

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(in thousands, except per share data)

(unaudited)

	Three Months Ended March 31,
	2019			2018
Revenue:
Collaboration and license revenue from related party	$	8,327		$	9,546
Total revenue		8,327			9,546
Operating expenses:
Research and development		15,354			14,742
General and administrative		5,501			4,660
Total operating expenses		20,855			19,402
Loss from operations		(12,528	)		(9,856	)
Other income (expense):
Interest income		1,121			613
Interest expense		(542	)		(174	)
Total other income, net		579			439
Net loss	$	(11,949	)	$	(9,417	)
Basic and diluted net loss per common share	$	(0.23	)	$	(0.19	)
Shares used to compute basic and diluted net loss per common share		52,395			48,853

See accompanying notes.

4

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(in thousands)

(unaudited)

	Three Months Ended March 31,
	2019			2018
Net loss	$	(11,949	)	$	(9,417	)
Unrealized gain (loss) on available-for-sale securities		194			(183	)
Comprehensive loss	$	(11,755	)	$	(9,600	)

See accompanying notes.

5

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(in thousands, except share data)

(unaudited)

	Common Stock					Additional Paid- In Capital			Note Receivable			Accumulated Other Comprehensive Loss			Accumulated Deficit			Total Stockholders’ Equity
	Shares			Amount
Balance as of December 31, 2017		48,837,060		$	49	$	368,553		$	(16	)	$	(119	)	$	(289,200	)	$	79,267
Net loss		—			—		—			—			—			(9,417	)		(9,417	)
Adoption of ASC Topic 606, Revenue from Contracts with Customers		—			—		—			—			—			(47,331	)		(47,331	)
Unrealized loss on investments		—			—		—			—			(183	)		—			(183	)
Issuance of common stock under equity incentive plans		313,886			—		1,128			—			—			—			1,128
Repurchased shares upon vesting of restricted stock units for tax withholdings		(79,585	)		—		(473	)		—			—			—			(473	)
Employee stock-based compensation		—			—		2,206			—			—			—			2,206
Compensation expense related to options granted to consultants		—			—		335			—			—			—			335
Balance as of March 31, 2018		49,071,361		$	49	$	371,749		$	(16	)	$	(302	)	$	(345,948	)	$	25,532

	Common Stock					Additional Paid- In Capital			Note Receivable			Accumulated Other Comprehensive Loss			Accumulated Deficit			Total Stockholders’ Equity
	Shares			Amount
Balance as of December 31, 2018		50,652,238		$	51	$	389,398		$	(16	)	$	(198	)	$	(374,497	)	$	14,738
Net loss		—			—		—			—			—			(11,949	)		(11,949	)
Unrealized gain on investments		—			—		—			—			194			—			194
Issuance of common stock through Equity Distribution Agreement, net of issuance costs (Note 9)		6,491,196			6		73,270			—			—			—			73,276
Issuance of common stock under equity incentive plans		690,100			1		2,851			—			—			—			2,852
Repurchased shares upon vesting of restricted stock units for tax withholdings		(107,619	)		—		(1,174	)		—			—			—			(1,174	)
Employee stock-based compensation		—			—		2,662			—			—			—			2,662
Compensation expense related to options granted to consultants		—			—		40			—			—			—			40
Balance as of March 31, 2019		57,725,915		$	58	$	467,047		$	(16	)	$	(4	)	$	(386,446	)	$	80,639

See accompanying notes.

6

CHEMOCENTRYX, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(in thousands)

(unaudited)

	Three Months Ended March 31,
	2019			2018
Operating activities
Net loss	$	(11,949	)	$	(9,417	)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Stock-based compensation		2,702			2,541
Depreciation of property and equipment		141			111
Amortization of right-of-use assets		239			—
Noncash interest income, net		(436	)		(366	)
Changes in assets and liabilities:
Accounts receivable due from related party		1,891			49,392
Prepaids and other current assets		(1,778	)		(83	)
Other assets		180			32
Accounts payable		327			(951	)
Other liabilities		(1,443	)		(1,372	)
Deferred revenue from related party		(8,160	)		1,061
Net cash provided by (used in) operating activities		(18,286	)		40,948
Investing activities
Purchases of property and equipment, net		(46	)		(32	)
Purchases of investments		(75,235	)		(77,941	)
Sales of investments		4,967			—
Maturities of investments		65,170			26,900
Net cash used in investing activities		(5,144	)		(51,073	)
Financing activities
Proceeds from issuance of common stock		73,276			—
Proceeds from exercise of stock options		2,573			1,128
Employees’ tax withheld and paid for restricted stock units		(1,174	)		(473	)
Net cash provided by financing activities		74,675			655
Net increase (decrease) in cash and cash equivalents		51,245			(9,470	)
Cash and cash equivalents at beginning of period		28,088			40,020
Cash and cash equivalents at end of period	$	79,333		$	30,550
Supplemental disclosures of cash flow information
Cash paid for interest	$	422		$	70
Right-of-use assets obtained in exchange for lease obligations (1)	$	1,301		$	—

(1) Amounts for the three months ended March 31, 2019 include the transition adjustment for the adoption of Topic 842.

See accompanying notes.

7

CHEMOCENTRYX, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

March 31, 2019

(unaudited)

1. Description of Business

ChemoCentryx, Inc. (the Company) commenced operations in 1997. The Company is a clinical-stage biopharmaceutical company focused on developing new medications targeted at inflammatory disorders, autoimmune diseases and cancer. The Company’s principal operations are in the United States and it operates in one segment.

Unaudited Interim Financial Information

The financial information filed is unaudited. The Condensed Consolidated Financial Statements included in this report reflect all adjustments (consisting only of normal recurring adjustments) that the Company considers necessary for the fair statement of the results of operations for the interim periods covered and of the financial condition of the Company at the date of the interim balance sheet. The December 31, 2018 Condensed Consolidated Balance Sheet was derived from audited financial statements. The results for interim periods are not necessarily indicative of the results for the entire year or any other interim period. The Condensed Consolidated Financial Statements should be read in conjunction with the Company’s financial statements and the notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2018 filed with the Securities and Exchange Commission on March 11, 2019.

2. Summary of Significant Accounting Policies

Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States (GAAP) requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from these estimates.

Concentration of Credit Risk

The Company invests in a variety of financial instruments and, by its policy, limits the amount of credit exposure with any one issuer, industry or geographic area.

Accounts receivable are typically unsecured and are concentrated in the pharmaceutical industry and government sector. Accordingly, the Company may be exposed to credit risk generally associated with pharmaceutical companies and government funded entities. The Company has not historically experienced any significant losses due to concentration of credit risk.

Accounts receivable consists of the following (in thousands):

	March 31, 2019		December 31, 2018
Vifor (International) Ltd., and/or its affiliates, or collectively, Vifor	$	167	$	2,058

8

Net Loss Per Share

Basic net loss per common share is computed by dividing net loss attributable to common stockholders by the weighted-average number of common shares outstanding during the period, without consideration for common stock equivalents.

Diluted net loss per share is computed by dividing net loss attributable to common stockholders by the sum of the weighted-average number of common shares outstanding and dilutive common stock equivalent shares outstanding for the period. The Company’s potentially dilutive common stock equivalent shares, which include incremental common shares issuable upon (i) the exercise of outstanding stock options and warrants, (ii) vesting of restricted stock units (RSUs) and restricted stock awards (RSAs), and (iii) the purchase from contributions to the 2012 Employee Stock Purchase Plan (the ESPP), (calculated based on the treasury stock method), are only included in the calculation of diluted net loss per share when their effect is dilutive.

For the three months ended March 31, 2019 and 2018, the following potentially dilutive securities were excluded from the calculation of diluted net loss per share due to their anti-dilutive effect:

	Three Months Ended March 31,
	2019		2018
Options to purchase common stock, including purchases from contributions to ESPP		11,073,806		11,824,877
Restricted stock units		374,352		459,682
Restricted stock awards		27,278		85,431
Warrants to purchase common stock		150,000		150,000
		11,625,436		12,519,990

Comprehensive Loss

Comprehensive loss comprises net loss and other comprehensive loss. For the periods presented, other comprehensive loss consists of unrealized gains and losses on the Company’s available-for-sale securities. For the three months ended March 31, 2019, amounts reclassified from accumulated other comprehensive loss to net loss for unrealized gains (losses) on available-for-sale securities were not significant, and were recorded as part of other income, net in the Condensed Consolidated Statements of Operations. For the three months ended March 31, 2018, there were no sales of investments and therefore there were no reclassifications.

Leases

The Company determines if an arrangement includes a lease at inception. Operating leases are included in operating lease right-of-use (ROU) assets, accrued and other current liabilities and other non-current liabilities on the Company’s Condensed Consolidated Balance Sheets. Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at commencement date. The Company uses the incremental borrowing rate based on the information available at lease commencement date in determining the present value of future payments. The operating lease ROU asset also excludes lease incentives. The Company’s lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise any such options. Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term. The Company has elected not to apply the recognition requirements for short-term leases. For lease agreements with lease and non-lease components, the Company generally accounts for them separately.

9

Recent Accounting Pronouncements

In February 2016, the Financial Accounting Standard Board (FASB) issued Accounting Standards Update (ASU) No. 2016-02, Leases (Topic 842). The new standard requires the Company to recognize the assets and liabilities that arise from leases on the balance sheet and disclose qualitative and quantitative information about its leasing arrangements. On January 1, 2019, the Company adopted this new standard using the modified retrospective approach in accordance with Leases – Targeted Improvements (ASU No. 2018-11). The Company elected the package of practical expedients permitted under the transition guidance within ASU No. 2018-11, which among other things, allowed the Company to carry forward the historical lease classification of those leases in place as of January 1, 2019. Results for the three months ended March 31, 2019 are presented under Topic 842. Prior period amounts have not been adjusted and continue to be reported in accordance with the Company’s historical accounting under previous lease guidance, ASC Topic 840, Leases (Topic 840).

The impact of the adoption of Topic 842 on the accompanying Condensed Consolidated Balance Sheet as of January 1, 2019 was as follows (in thousands):

	December 31, 2018		Adjustments Due to the Adoption of Topic 842		January 1, 2019
Balance Sheet
Assets:
Operating lease right-of-use assets	$	—	$	1,301	$	1,301
Liabilities:
Operating lease liabilities:
Accrued and other current liabilities (1)		12,969		955		13,924
Other non-current liabilities (2)		387		346		733

(1) Includes deferred rent and current portion of operating lease liabilities

(2) Includes deferred rent and non-current portion of operating lease liabilities

In June 2016, the FASB issued ASU 2016-13, Financial Instruments – Credit Losses: Measurement of Credit Losses on Financial Instruments. The new standard replaces the incurred loss impairment methodology under the current standard with a methodology that reflects expected credit losses and requires consideration of a broader range of reasonable and supportable information to inform credit loss estimates. The Company will be required to use a forward-looking expected credit loss model for accounts receivables and other financial instruments. Credit losses relating to available-for-sale debt securities will also be recorded through an allowance for credit losses rather than as a reduction in the amortized cost basis of the securities. The new standard will be effective for the Company on January 1, 2020, with early adoption permitted on January 1, 2019. The Company is currently evaluating the impact of the adoption of this standard on its financial statements and does not expect the adoption of this accounting guidance to have a material impact on the consolidated financial statements.

In June 2018, the FASB issued ASU No. 2018-07, Compensation – Stock Compensation (Topic 718). The new standard simplifies the accounting for share-based payments to nonemployees by aligning it with the accounting for share-based payments to employees, with certain exceptions. The Company adopted this new standard on January 1, 2019. The adoption of this accounting guidance did not have a material impact on the consolidated financial statements.

The Company has reviewed other recent accounting pronouncements and concluded they are either not applicable to the business or that no material effect is expected on the consolidated financial statements as a result of future adoption.

In August 2018, the SEC adopted amendments to certain disclosure requirements in Securities Act Release No. 33-10532, Disclosure Update and Simplification. These amendments eliminated, modified, or integrated into other SEC requirements certain disclosure rules. Among the amendments was the requirement to present an analysis of changes in stockholders’ equity in the interim financial statements included in quarterly reports on Form 10-Q. The analysis, which can be presented as a footnote or separate statement, is required for the current and comparative quarter and year-to-date interim periods. The amendments became effective for the Company in its interim financial statements for the quarter ended March 31, 2019. The adoption of these SEC amendments did not have a material effect on the Company’s financial position, results of operations, cash flows or stockholders’ equity.

10

3. Cash Equivalents and Investments

The amortized cost and fair value of cash equivalents and investments at March 31, 2019 and December 31, 2018 were as follows (in thousands):

	March 31, 2019
	Amortized		Gross Unrealized					Fair
	Cost		Gains		Losses			Value
Money market fund	$	71,368	$	—	$	—		$	71,368
U.S. treasury securities		35,798		12		(1	)		35,809
Commercial paper		49,638		—		—			49,638
Asset-backed securities		27,147		6		—			27,153
Corporate debt securities		46,046		20		(41	)		46,025
Total available-for-sale securities	$	229,997	$	38	$	(42	)	$	229,993
Classified as:
Cash equivalents								$	75,248
Short-term investments									142,777
Long-term investments									11,968
Total available-for-sale securities								$	229,993

	December 31, 2018
	Amortized		Gross Unrealized					Fair
	Cost		Gains		Losses			Value
Money market fund	$	22,073	$	—	$	—		$	22,073
U.S. treasury securities		23,013		—		(13	)		23,000
Commercial paper		45,683		—		—			45,683
Asset-backed securities		29,127		—		(34	)		29,093
Corporate debt securities		55,228		—		(151	)		55,077
Total available-for-sale securities	$	175,124	$	—	$	(198	)	$	174,926
Classified as:
Cash equivalents								$	26,030
Short-term investments									148,896
Long-term investments									—
Total available-for-sale securities								$	174,926

Cash equivalents in the tables above exclude cash of $4.1 million and $2.1 million as of March 31, 2019 and December 31, 2018, respectively. All available-for-sale securities held as of March 31, 2019 had contractual maturities of less than two years. There have been no significant realized gains or losses on available-for-sale securities for the periods presented. The Company applies the specific identification method to determine the cost basis of the securities sold. No significant available-for-sale securities held as of March 31, 2019 have been in a continuous unrealized loss position for more than 12 months. As of March 31, 2019, unrealized losses on available-for-sale investments are not attributed to credit risk and are considered to be temporary. The Company believes that it is more-likely-than-not that investments in an unrealized loss position will be held until maturity or the recovery of the cost basis of the investment. The Company believes it has no other-than-temporary impairments on its securities because it does not intend to sell these securities and it believes it is not more likely than not that it will be required to sell these securities before the recovery of their amortized cost basis. To date, the Company has not recorded any impairment charges on marketable securities related to other-than-temporary declines in market value.

11

4. Fair Value Measurements

The Company determines the fair value of financial assets and liabilities using three levels of inputs as follows:

Level 1—Inputs which include quoted prices in active markets for identical assets and liabilities.

Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

Recurring Fair Value Measurements

The Company’s financial assets subject to fair value measurements on a recurring basis and the level of inputs used in such measurements were as follows as of March 31, 2019 and December 31, 2018 (in thousands):

	March 31, 2019
Description	Level 1		Level 2		Level 3		Total
Money market fund	$	71,368	$	—	$	—	$	71,368
U.S. treasury securities		—		35,809		—		35,809
Commercial paper		—		49,638		—		49,638
Asset-backed securities		—		27,153		—		27,153
Corporate debt securities		—		46,025		—		46,025
Total assets	$	71,368	$	158,625	$	—	$	229,993

	December 31, 2018
Description	Level 1		Level 2		Level 3		Total
Money market fund	$	22,073	$	—	$	—	$	22,073
U.S. treasury securities		—		23,000		—		23,000
Commercial paper		—		45,683		—		45,683
Asset-backed securities		—		29,093		—		29,093
Corporate debt securities		—		55,077		—		55,077
Total assets	$	22,073	$	152,853	$	—	$	174,926

During the three months ended March 31, 2019, there were no transfers between Level 1 and Level 2 financial assets. When the Company uses observable market prices for identical securities that are traded in less active markets, the Company classifies its marketable debt instruments as Level 2. When observable market prices for identical securities are not available, the Company prices its marketable debt instruments using non-binding market consensus prices that are corroborated with observable market data; quoted market prices for similar instruments; or pricing models, such as a discounted cash flow model, with all significant inputs derived from or corroborated with observable market data. Non-binding market consensus prices are based on the proprietary valuation models of pricing providers or brokers. These valuation models incorporate a number of inputs, including non-binding and binding broker quotes; observable market prices for identical or similar securities; and the internal assumptions of pricing providers or brokers that use observable market inputs and, to a lesser degree, unobservable market inputs. The Company corroborates non-binding market consensus prices with observable market data using statistical models when observable market data exists. The discounted cash flow model uses observable market inputs, such as LIBOR-based yield curves, currency spot and forward rates, and credit ratings.

12

Other Fair Value Measurements

The carrying amount and estimated fair value of financial instruments not recorded at fair value at March 31, 2019 and December 31, 2018 were as follows (in thousands):

	March 31, 2019				December 31, 2018
	Carrying Amount		Estimated Fair Value		Carrying Amount		Estimated Fair Value
Long-term debt, net (1)	$	19,714	$	19,954	$	19,689	$	19,847

(1) Carrying amounts of long-term debt were net of unamortized debt discounts of $286,000 and $311,000 as of March 31, 2019 and December 31, 2018, respectively.

The fair value of the Company’s long-term debt is estimated using the net present value of future debt payments, discounted at an interest rate that is consistent with market interest rates, which is a Level 2 input.

5. Accrued and Other Current Liabilities

Accrued and other current liabilities consist of the following (in thousands):

	March 31, 2019		December 31, 2018
Research and development related	$	8,220	$	8,466
Compensation related		1,460		2,767
Consulting and professional services		779		811
Current portion of operating lease liability		1,357		—
Other		1,049		925
	$	12,865	$	12,969

6. Long-term Debt

On December 28, 2017 (the Closing Date), the Company entered into a Loan and Security Agreement with Hercules Capital, Inc. (Hercules) which the Company amended in December 2018, pursuant to which term loans in an aggregate principal amount of up to $50.0 million (the Credit Facility) are available to the Company in three tranches, subject to certain terms and conditions. As of March 31, 2019, the Company had borrowed $20.0 million under the Credit Facility with up to $25.0 million remaining available for future borrowing, subject to Hercules’ approval, through June 15, 2019.

Advances under the Credit Facility bear an interest rate equal to the greater of either (i) 8.05% plus the prime rate as reported from time to time in The Wall Street Journal minus 4.75%, and (ii) 8.05%. At March 31, 2019, the interest rate on the outstanding borrowings under the Credit Facility was 8.80%. For advances made under the first and second tranches, the Company will make interest-only payments through July 1, 2021, and will then repay the principal balance and interest on the advances in equal monthly installments after the interest-only period and continuing through December 1, 2022. For advances made under the third tranche, the Company will make interest-only payments for the first 30 months, and will then repay the principal balance and interest on the advances in equal monthly installments after the interest-only period with each advance repaid 48 months after it is drawn.

The Company may prepay advances under the Credit Facility, in whole or in part, at any time, subject to a prepayment charge equal to: (a) 1.5% of the amount so prepaid, if such prepayment occurs during the second year following the Closing Date; and (b) 1.0% of the amount so prepaid, if such prepayment occurs after the second year following the Closing Date. The Credit Facility is secured by substantially all of the Company’s assets, excluding intellectual property.

In addition, Hercules has the right to participate, in an amount up to $2.0 million, in any subsequent equity financing broadly marketed to multiple investors in an amount greater than $20.0 million. The Credit Facility also includes customary affirmative restrictions on the payment of dividends and negative covenants, and events of default, the occurrence and continuance of which provide Hercules with the right to demand immediate repayment of all principal and unpaid interest under the Credit Facility, and to exercise remedies against the Company and the collateral securing the Credit Facility. The Company was in compliance with all loan covenants for all periods presented.

The Company will pay an end-of-term charge for each tranche which will occur on the earliest of (i) the applicable tranche maturity date; (ii) the date that the Company prepays all of the outstanding principal under each tranche in full, or (iii) the date the loan payments are accelerated due to an event of default. For the first and second tranches, the end of term charge is $0.9 million and $0.3 million, respectively. In the case of the third tranche, the charge is 6.25% of the aggregate amount of the advances applicable to such tranche.

13

In addition, the Company pays a commitment charge of 1% of the advances made under the Credit Facility, with a minimum charge of $162,500 paid on the Closing Date. Also, the Company reimbursed Hercules for costs incurred related to the Credit Facility. These charges were recorded as discounts to the carrying value of the loan and are amortized over the term of the loan using the effective interest method.

As of March 31, 2019, the Company had outstanding borrowings under the Credit Facility of $19.7 million, net of discounts of $0.3 million. Future minimum principal payments, which exclude the end of term charge, related to the Credit Facility as of March 31, 2019 are as follows (in thousands):

	Amounts
Year ending December 31:
Remaining of fiscal year 2019	$	—
2020		—
2021		6,363
2022		13,637
Total minimum payments		20,000
Less: amount representing debt discount		(286	)
Present value of remaining debt payments		19,714
Less: current portion		—
Noncurrent portion	$	19,714

7. Commitments

Operating Leases

As described further in “Note 2. Summary of Significant Accounting Policies”, the Company adopted Topic 842 as of January 1, 2019. The comparative information has not been restated and continues to be reported under the accounting standards in effect for those periods.

In May 2004, the Company entered into a noncancelable operating lease for its current office and primary research facility located in Mountain View, California. The Company received a discounted lease rate during the first year of the agreement. In August 2012, the Company entered into an amendment to the lease agreement for the same facility to extend the term through April 2019. In April 2017, the Company entered into a second amendment to the lease agreement for the same facility to extend the term of the lease through April 2020.

The balance sheet classification of the Company’s operating lease liabilities was as follows (in thousands):

	March 31,		December 31,
	2019		2018
Accrued and other current liabilities (1)	$	1,357	$	244
Other non-current liabilities (2)		124		143
Total lease liabilities	$	1,481	$	387

(1) Includes current portion of operating lease liabilities as of March 31, 2019 and deferred rent as of December 31, 2018

(2) Includes non-current portion of operating lease liabilities as of March 31, 2019 and deferred rent as of December 31, 2018

14

The component of lease costs, which was included in operating expenses in the Company’s Condensed Consolidated Statements of Operations, was as follows (in thousands):

	Three Months Ended March 31,
	2019		2018
Operating lease cost	$	268	$	268

Cash paid for amounts included in the measurement of lease liabilities for the three months ended March 31, 2019 was $236,000 and was included in net cash used in operating activities in the Company’s Condensed Consolidated Statements of Cash Flows.

Future minimum lease payments under all noncancelable operating leases as of March 31, 2019 are as follows (in thousands):

	Operating leases
Year ending December 31:
Remaining of fiscal year 2019	$	1,080
2020		501
Total minimum payments		1,581
Less: interest		(100	)
Present value of lease liabilities	$	1,481

As of March 31, 2019, the weighted-average remaining lease term was 1.1 years and the weighted-average operating discount rate used to determine the operating lease liability was 11.0%.

8. Related-Party Transactions

Vifor

Vifor held 10,676,825 shares of the Company’s common stock as of March 31, 2019. The Company has collaboration agreements with Vifor: the Avacopan Agreements and the CCX140 Agreements (each as described below). See “Note 2. Summary of Significant Accounting Policies – Concentration of Credit Risk” for additional information on accounts receivable balance due from Vifor.

Avacopan Agreements

In May 2016, the Company entered into an exclusive collaboration and license agreement with Vifor pursuant to which the Company granted Vifor exclusive rights to commercialize avacopan in Europe and certain other markets (the Avacopan Agreement). Avacopan is the Company’s lead drug candidate for the treatment of patients with anti-neutrophil cytoplasmic auto-antibody associated vasculitis (AAV) and other rare diseases. The Avacopan Agreement also provided Vifor with an exclusive option to negotiate during 2016 a worldwide license agreement for one of the Company’s other drug candidates, CCX140, an orally-administered inhibitor of the chemokine receptor known as CCR2. In connection with the Avacopan Agreement, the Company received a non-refundable upfront payment of $85.0 million, comprising $60.0 million in cash and $25.0 million in the form of an equity investment to purchase 3,333,333 shares of the Company’s common stock at a price of $7.50 per share.

In February 2017, Vifor and the Company expanded the Vifor territories under the Avacopan Agreement to include all markets outside the United States and China (the Avacopan Amendment). In connection with this February 2017 arrangement, the Company received a $20.0 million upfront payment for the expanded rights. In June 2018, Vifor and the Company further expanded the Vifor territories under the Avacopan Agreement to provide Vifor with exclusive commercialization rights in China (the Avacopan Letter Agreement, and together with the Avacopan Agreement and the Avacopan Amendment, the Avacopan Agreements). The Company retains control of ongoing and future development of avacopan (other than country-specific development in the licensed territories) and all commercialization rights to avacopan in the United States. In consideration for the Avacopan Letter Agreement, the Company received a $5.0 million payment for the expanded rights.

Upon achievement of certain regulatory and commercial milestones with avacopan, the Company will receive additional payments of up to $460.0 million under the Avacopan Agreement. In addition, the Company will receive royalties, with rates ranging from the low teens to the mid-twenties, on future potential net sales of avacopan by Vifor in the licensed territories. In December 2017, the Company achieved a $50.0 million regulatory milestone when the European Medicines Agency (EMA) validated the Company’s Conditional marketing authorisation (CMA) application for avacopan for the treatment of AAV.

The Company identified the following material promises under the Avacopan Agreements: (1) the license related to avacopan; (2) the development and regulatory services for the submission of the marketing authorisation application (MAA); and (3) an exclusive option to negotiate a worldwide license agreement for CCX140, which expired in 2016. The Company considered that the license has standalone functionality and is capable of being distinct. However, the Company determined that the license is not distinct

15

from the development and regulatory services within the context of the agreement because Vifor is dependent on the Company to execute the development and regulatory activities in order for Vifor to benefit from the license. As such, the license is combined with the development and regulatory services into a single performance obligation. The exclusive option related to CCX140 is a separate performance obligation and the Company determined that its transaction price is not material. As such, the transaction price under this arrangement is allocated to the license and the development and regulatory services.

As of March 31, 2019, the transaction price of $153.0 million consists of the following:

• $78.0 million upfront payment under the May 2016 Avacopan Agreement. Of the total $85.0 million upfront payment received under the May 2016 Avacopan Agreement, $7.0 million was allocated to the issuance of 3,333,333 shares of the Company’s common stock valued at $2.10 per share, the closing stock price on the effective date of the agreement, May 9, 2016. The remaining $78.0 million was allocated to the transaction price under this arrangement;

• $20.0 million upfront payment under the February 2017 Avacopan Amendment;

• $50.0 million regulatory milestone payment achieved upon the validation of the Company’s CMA application by the EMA, for avacopan for the treatment of AAV in December 2017; and

• $5.0 million non-refundable upfront payment under the Avacopan Letter Agreement.

The Company will re-evaluate the transaction price in each reporting period and as uncertain events are resolved or other changes in circumstances occur.

The Company determined that the combined performance obligation will be performed over the duration of the contract, which began on the effective date of May 9, 2016 and ends upon completion of development and regulatory services. The Company uses a cost-based input method to measure proportional performance and to calculate the corresponding amount of revenue to recognize. The Company believes this is the best measure of progress because other measures do not reflect how the Company transfers its performance obligation to Vifor. In applying the cost-based input method of revenue recognition, the Company measures actual costs incurred relative to budgeted costs to fulfill the combined performance obligation. These costs consist primarily of third-party contract costs. Revenue is recognized based on actual costs incurred as a percentage of total budgeted costs as the Company completes its performance obligations.

For the three months ended March 31, 2019 and 2018, the Company recognized $6.6 million and $8.2 million of collaboration and license revenue under the Avacopan Agreements, respectively.

CCX140 Agreements

In December 2016, the Company entered into a second collaboration and license agreement with Vifor pursuant to which the Company granted Vifor exclusive rights to commercialize CCX140 (the CCX140 Agreement) in markets outside the United States and China. CCX140 is an orally-administered inhibitor of the chemokine receptor known as CCR2. The Company retains marketing rights in the United States and China, while Vifor has commercialization rights in the rest of the world. Pursuant to the CCX140 Agreement, the Company is responsible for the clinical development of CCX140 in rare renal diseases and is reimbursed for Vifor’s equal share of such development cost. Vifor retains an option to solely develop and commercialize CCX140 in more prevalent forms of chronic kidney disease (CKD). Should Vifor later exercise the CKD option, the Company would receive co-promotion rights for CKD in the United States. Under the terms of the CCX140 Agreement, the Company received a non-refundable upfront payment of $50.0 million in 2017.

In June 2018, the Company and Vifor entered into a letter agreement to expand Vifor’s rights to include the right to exclusively commercialize CCX140 in China (the CCX140 Letter Agreement). In connection with the CCX140 Letter Agreement, the Company received a non-refundable payment of $5.0 million. The Company and Vifor also entered into an amendment to the CCX140 Agreement (the CCX140 Amendment, and together with the CCX140 Agreement and the CCX140 Letter Agreement, the CCX140 Agreements) to clarify the timing of certain payments with respect to development funding of the CCX140 program by Vifor, and the Company received a non-refundable payment of $11.5 million. The Company retains control of ongoing and future development of CCX140 (other than country-specific development in the licensed territories), and all commercialization rights to CCX140 in the United States.

Upon achievement of certain regulatory and commercial milestones with CCX140, the Company will receive additional payments of up to $625.0 million under the CCX140 Agreement. In addition, the Company will receive tiered royalties, with rates ranging from ten to the mid-twenties, on net sales of CCX140 in the licensed territories.

The Company identified the following material promises under the CCX140 Agreements: (1) the license related to CCX140; and (2) the development and regulatory services for the submission of the MAA. The Company considered that the license has standalone functionality and is capable of being distinct. However, the Company determined that the license is not distinct from the development and regulatory services within the context of the agreement because Vifor is dependent on the Company to execute the development and regulatory activities in order for Vifor to benefit from the license. As such, the license is combined with the development and regulatory services into a single performance obligation.

16

As of March 31, 2019, the transaction price of $113.5 million consists of the following:

• $50.0 million upfront payment under the CCX140 Agreement;

• $58.5 million of CCX140 development funding by Vifor; and

• $5.0 million non-refundable upfront payment under the CCX140 Letter Agreement.

The Company will re-evaluate the transaction price in each reporting period and as uncertain events are resolved or other changes in circumstances occur.

The Company determined that the combined performance obligation will be performed over the duration of the contract, which began on the effective date of December 22, 2016 and ends upon completion of development and regulatory services. The Company uses a cost-based input method to measure proportional performance and to calculate the corresponding amount of revenue to recognize. The Company believes this is the best measure of progress because other measures do not reflect how the Company transfers its performance obligation to Vifor. In applying the cost-based input method of revenue recognition, the Company measures actual costs incurred relative to budgeted costs to fulfill the combined performance obligation. These costs consist primarily of third-party contract costs. Revenue is recognized based on actual costs incurred as a percentage of total budgeted costs as the Company completes its performance obligations. For the three months ended March 31, 2019 and 2018, the Company recognized $1.7 million and $1.3 million of collaboration and license revenue under the CCX140 Agreements, respectively.

The following table presents the contract assets and liabilities for all of the Company’s revenue contracts as of the following dates (in thousands):

	March 31,			December 31,
	2019			2018
Contract asset:
Accounts receivable	$	167		$	2,058
Contract liability:
Deferred revenue		(126,401	)		(134,561	)

During the three months ended March 31, 2019, the Company recognized the following revenue as a result of changes in the contract asset and the contract liability balances (in thousands):

	Three Months Ended March 31, 2019
Revenue recognized in the period from:
Amount included in contract liability at the beginning of the period	$	8,160
Performance obligations satisfied (or partially satisfied) in previous periods	$	(896	)

17

9. Stockholders’ Equity

Stock Options

During the three months ended March 31, 2019, the Company had the following activities under its equity incentive plans:

	Available for Grant			Shares			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value
Balance at December 31, 2018		1,708,516			10,720,200		$	8.39
Shares authorized		2,000,000			—
Granted (1)		(1,529,886	)		1,384,133			11.44
Exercised (2)		107,619			(485,012	)		5.88
Forfeited and expired (3)		584,832			(578,165	)		6.85
Outstanding at March 31, 2019		2,871,081			11,041,156		$	8.96		6.40	$	55,107,905
Vested and expected to vest, net of estimated forfeiture at March 31, 2019					10,648,497		$	8.91		6.29	$	53,745,822
Exercisable at March 31, 2019					7,200,618		$	8.56		5.00	$	39,078,897

(1) The difference between shares granted in the number of shares available for grant and outstanding options represents the RSUs and RSAs granted for the period.

(2) Shares presented as available for grant represents shares repurchased for tax withholding upon vesting of RSUs.

(3) The difference between shares forfeited and expired in the number of shares available for grant and outstanding options represents the RSUs canceled during the period.

Restricted Stock

During the three months ended March 31, 2019, the activity for restricted stock is summarized as follows:

	Shares			Weighted Average Grant-Date Fair Value
Balance at December 31, 2018		467,632		$	8.47
Granted		145,753			11.23
Vested		(205,088	)		7.38
Canceled		(6,667	)		10.86
Unvested at March 31, 2019		401,630		$	9.99

Stock-based Compensation

Total stock-based compensation expense was $2.7 million and $2.5 million during the three months ended March 31, 2019 and 2018, respectively. As of March 31, 2019, $19.4 million, $2.7 million and $38,000 of total unrecognized compensation expenses associated with outstanding employee stock options, unvested restricted stock, and the ESPP, net of estimated forfeitures, were expected to be recognized over a weighted-average period of 2.74, 1.66 and 0.12 years, respectively.

Equity Distribution Agreement

In December 2018, the Company entered into an Equity Distribution Agreement (EDA), pursuant to which the Company may offer and sell, from time to time, shares of the Company’s common stock, par value $0.001 per share, having an aggregate offering price of up to $75.0 million. For the three months ended March 31, 2019, the Company sold 6,491,196 shares of its common stock pursuant to its EDA for net proceeds of $73.3 million. These sales fully exhausted the amount available under the EDA. Accordingly, no further sales will be made under the EDA.

18

Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion and analysis should be read in conjunction with our financial statements and accompanying notes included in this Quarterly Report on Form 10-Q and the financial statements and accompanying notes thereto and Management’s Discussion and Analysis of Financial Condition and Results of Operations included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed with the Securities and Exchange Commission, or SEC, on March 11, 2019.

Forward-Looking Statements

This Quarterly Report on Form 10-Q contains forward-looking statements that involve risks and uncertainties. All statements other than statements of historical facts contained in this Quarterly Report on Form 10-Q are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may,” “could,” “will,” “would,” “should,” “expect,” “plan,” “aim,” “anticipate,” “believe,” “estimate,” “intend,” “predict,” “seek,” “contemplate,” “potential” or “continue” or the negative of these terms or other comparable terminology. These forward-looking statements include, but are not limited to, statements about:

• the initiation, timing, progress and results of our preclinical studies and clinical trials, and our research and development programs;

• our ability to advance drug candidates into, and successfully complete, clinical trials;

• the commercialization of our drug candidates;

• the implementation of our business model, strategic plans for our business, drug candidates and technology;

• the scope of protection we are able to establish and maintain for intellectual property rights covering our drug candidates and technology;

• estimates of our expenses, future revenues, capital requirements and our needs for additional financing;

• the timing or likelihood of regulatory filings and approvals;

• our ability to maintain and establish collaborations or obtain additional government grant funding;

• our financial performance; and

• developments relating to our competitors and our industry.

These statements relate to future events or to our future financial performance and involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements. Factors that may cause actual results to differ materially from current expectations include, among other things, those included in “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed with the SEC on March 11, 2019.

Any forward-looking statement in this Quarterly Report on Form 10-Q reflects our current views with respect to future events and is subject to these and other risks, uncertainties and assumptions relating to our operations, results of operations, industry and future growth. Given these uncertainties, you should not place undue reliance on these forward-looking statements. For all forward-looking statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Except as required by law, we assume no obligation to update or revise these forward-looking statements for any reason, even if new information becomes available in the future.

ChemoCentryx^®, the ChemoCentryx logo, Traficet^™ and Traficet-EN^™ are our trademarks in the United States, the European Community, Australia and Japan. EnabaLink^® and RAM^® are our trademarks in the United States. Each of the other trademarks, trade names or service marks appearing in this Quarterly Report on Form 10-Q belongs to its respective holder.

Unless the context requires otherwise, in this Quarterly Report on Form 10-Q the terms “ChemoCentryx,” “we,” “us” and “our” refer to ChemoCentryx, Inc., a Delaware corporation, and our subsidiaries taken as a whole unless otherwise noted.

19

Overview

ChemoCentryx is a biopharmaceutical company developing new medications targeted at inflammatory disorders, autoimmune diseases and cancer. Each of our drug candidates is designed to selectively block a specific chemoattractant receptor, leaving the rest of the immune system intact. Our drug candidates are small molecules, which are orally administered, and, if approved, could address unmet medical needs, including improved efficacy, and offer significant quality of life benefits, since patients swallow a capsule or pill instead of having to visit a clinic for an infusion or undergo an injection.

In 2016, we executed on our strategy to form an alliance with a partner that could provide upfront fees and milestone payments to support the clinical development of our two leading drug candidates, avacopan and CCX140, to registration and pay us royalties upon sales in international markets, while we develop our own commercial infrastructure to sell directly in the United States.

To help communicate the breadth of our drug discovery platform, we have segmented our pipeline into early stage and late stage drug candidates.

Late Stage Drug Candidates

We have chosen to focus initially on orphan indications, where drug candidates tend to enjoy a faster path to market and better reimbursement. Our leading drug candidates address areas of clear unmet need, where the current standard of care, or SOC, is insufficient to halt progression of the disease and/or where today’s treatment options come with serious side effects, such as those which accompany the prolonged use of steroids:

Avacopan (CCX168) – Inhibition of Complement-Mediated Pathways in Orphan Diseases

Avacopan (formerly CCX168) is an orally-administered complement inhibitor targeting the C5a receptor, or C5aR, and is being developed for orphan diseases, including (i) anti-neutrophil cytoplasmic auto-antibody associated vasculitis, or AAV, a devastating autoimmune disease that damages blood vessels and can lead to kidney failure, pulmonary failure and damage to other tissues; (ii) complement 3 glomerulopathy, or C3G, a debilitating disease that can lead to kidney failure; and (iii) moderate and severe hidradenitis suppurativa, or HS, a chronic, inflammatory, debilitating skin disease characterized by recurrent, painful, nodules and abscesses, ultimately leading to the formation of draining fistulas (also known as sinus tracts) as well as scarring.

Avacopan has been granted orphan drug designation by the U.S. Food and Drug Administration, or FDA, for the treatment of AAV and C3G and by the European Medicines Agency, or EMA, for the treatment of C3G and microscopic polyangiitis and granulomatosis with polyangiitis, both forms of AAV. Additionally, avacopan had been granted PRIority MEdicines, or PRIME, designation from the EMA, to expedite its clinical development, and to potentially accelerate its marketing authorization.

Following completion of two Phase II clinical trials in patients with AAV, in which avacopan was well-tolerated and provided effective steroid-free control of the disease, we launched the Phase III ADVOCATE trial in December 2016. The FDA and the EMA concurred with the design of the study. ADVOCATE is a randomized, double-blind two-arm study which enrolled over 300 patients at over 200 sites in the United States, Canada, Europe, Australia, New Zealand and Japan. Patient enrollment of the Phase III ADVOCATE trial was completed in July 2018 and we expect to report topline data from this trial in the fourth quarter of 2019. Additionally, we launched a registration-supporting clinical trial to study avacopan for the treatment of patients with C3G for which we aim to complete enrollment in 2019 and initiated a large placebo-controlled Phase IIb clinical trial, the AURORA trial, for the treatment of patients with moderate to severe HS in the fourth quarter of 2018.

CCX140 – Chronic and Orphan Kidney Diseases

CCX140, an orally-administered inhibitor of the chemokine receptor known as CCR2, has been in development for diabetic nephropathy, or DN, a form of chronic kidney disease, or CKD, and is now being developed for focal segmental glomerulosclerosis, or FSGS, a rare renal disease characterized by progressive proteinuria, excess protein in the urine, and impaired renal function. CCX140 has been granted orphan drug designation by the FDA for the treatment of FSGS.

A global Phase II clinical trial of CCX140 in patients with DN met its primary endpoint by demonstrating that CCX140 given orally once daily added to a SOC renin-angiotensin-aldosterone system inhibitor treatment resulted in a statistically significant reduction in proteinuria, beyond that achieved with SOC alone, with the most pronounced effect shown in the

20

patients with highest levels of proteinuria. Based on the safety and efficacy data related to reduction in proteinuria observed in the Phase II trial in DN, we launched two Phase IIb clinical trials, the LUMINA trials, of CCX140 for the treatment of primary FSGS, with and without nephrotic syndrome, for which there are currently no FDA-approved treatments.

Kidney Health Alliance with Vifor

In May 2016, we announced a partnership, which we refer to as the Avacopan Agreement, with Vifor (International) Ltd., and/or its affiliates, or collectively, Vifor, a European-based world leader specializing in kidney disease. While under this agreement we retained all rights to the United States and China, we granted Vifor exclusive commercialization rights to avacopan in Europe and certain other international markets. In December 2016, we entered into an additional agreement with Vifor, which we refer to as the CCX140 Agreement, relating to CCX140, our other late stage drug candidate. Under the CCX140 Agreement, we again retained all rights to the United States and China and we granted Vifor exclusive worldwide commercialization rights outside of the United States and China. In February 2017, we announced a further agreement with Vifor that harmonized the geographic commercialization rights underlying the agreements for both drug candidates, which we refer to as the Avacopan Amendment. In June 2018, we entered into additional agreements with Vifor to further expand Vifor’s exclusive commercialization rights to include China under the Avacopan Agreement (the Avacopan Letter Agreement) and the CCX140 Agreement (the CCX140 Letter Agreement).

We have secured $215 million in upfront cash and milestone payments pursuant to our agreements with Vifor and are eligible for additional substantial milestone payments. Through our alliance, we maintain the commercialization rights to avacopan and CCX140 in the United States, and also retain control of the clinical development programs for orphan renal disease. Vifor gained the exclusive commercialization rights for all other international markets, and is obligated to pay us tiered royalties, with rates ranging from ten to the mid-twenties, on potential net sales.

At a future time defined in the CCX140 Agreement, Vifor has an option to solely develop and commercialize CCX140 in more prevalent forms of CKD. Should Vifor later exercise the CKD option, we would receive co-promotion rights for CKD in the United States, and we estimate that the clinical development and registration process for CKD would end at approximately the same time as Orphan Drug exclusivity.

Early Stage Drug Candidates

While we have focused initially on kidney and dermatological diseases, our target-specific and selective approach designed to stop the spread of inflammatory disease-inducing cells shows promise in other disease areas. Over time we plan to bring forward drug candidates to treat a range of inflammatory and autoimmune disorders, as well as cancer, where our drug candidate CCX872 has shown promise in a Phase Ib trial for advanced pancreatic cancer. We expect that our ability to do so will grow as we increase our scale and to the extent that we start to earn revenues and royalties from the commercialization of our late stage kidney disease franchise.

Since commencing our operations in 1997, our efforts have focused on research, development and the advancement of our drug candidates into and through clinical trials. As a result, we have incurred significant losses. We have funded our operations primarily through the sale of convertible preferred and common stock, contract revenue under our collaborations, government contracts and grants and borrowings under equipment financing arrangements.

As of March 31, 2019, we had an accumulated deficit of $386.4 million. We expect to continue to incur net losses as we develop our drug candidates, expand clinical trials for our drug candidates currently in clinical development, expand our research and development activities, expand our systems and facilities, seek regulatory approvals and engage in commercialization preparation activities in anticipation of FDA approval of our drug candidates. In addition, if a product is approved for commercialization, we will need to expand our organization. Significant capital is required to launch a product and many expenses are incurred before revenues are received. We are unable to predict the extent of any future losses or when we will become profitable, if at all.

Critical Accounting Policies and Significant Judgments and Estimates

We adopted Accounting Standards Codification Topic 842, Leases, on January 1, 2019, resulting in changes to our accounting policies for leases. There have been no material changes in significant judgments and estimates for our critical accounting policies during the three months ended March 31, 2019, as compared to those disclosed in “Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations—Critical Accounting Policies and Significant Judgments and Estimates” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed with the SEC on March 11, 2019.

21

Results of Operations

Revenue

We have not generated any revenue from product sales. For the periods presented, our revenues were derived from collaboration and license revenue related to the Avacopan Agreement and the CCX140 Agreement, in each case, as amended, and the related letter agreements. Total revenue for the three months ended March 31, 2019, as compared to the same period in the prior year, was as follows (in thousands):

	Three Months Ended March 31
	2019			2018
Collaboration and license revenue from related party	$	8,327		$	9,546
Total revenue	$	8,327		$	9,546
Dollar decrease	$	(1,219	)
Percentage decrease		-13	%

We use a cost-based input method to measure proportional performance and to calculate the corresponding amount of revenue to recognize. In applying the cost-based input method of revenue recognition, we measure actual costs incurred relative to budgeted costs to fulfill the combined performance obligation. These costs consist primarily of third-party contract costs. Revenue is recognized based on actual costs incurred as a percentage of total budgeted costs as we complete our performance obligations.

The decrease in revenue from 2018 to 2019 for the three month period was primarily due to lower actual costs incurred related to the Avacopan Agreement, partially offset by higher actual costs incurred related to the CCX140 Agreement.

Research and development expenses

Research and development expenses represent costs incurred to conduct basic research, the discovery and development of novel small molecule therapeutics, development of our suite of proprietary drug discovery technologies, preclinical studies and clinical trials of our drug candidates. We recognize all research and development expenses as they are incurred. These expenses consist primarily of salaries and related benefits, including stock-based compensation, third-party contract costs relating to research, formulation, manufacturing, preclinical study and clinical trial activities, laboratory consumables, and allocated facility costs. Total research and development expenses for the three months ended March 31, 2019, as compared to the same period in the prior year, were as follows (in thousands):

	Three Months Ended March 31,
	2019			2018
Research and development expenses	$	15,354		$	14,742
Dollar increase	$	612
Percentage increase		4	%

The increase in research and development expenses from 2018 to 2019 for the three month period was primarily due to the initiation and patient enrollment of the avacopan Phase IIb clinical trial in patients with HS and the CCX140 Phase II clinical trials in patients with FSGS. These increases were partially offset by a decrease in the avacopan Phase III ADVOCATE pivotal trial expenses as the study was fully enrolled in July 2018.

22

The following table summarizes our research and development expenses by project (in thousands):

	Three Months Ended March 31,
	2019		2018
Phase I	$	138	$	290
Phase II		4,641		3,127
Phase III		7,028		7,646
Research and drug discovery		3,547		3,679
Total R&D	$	15,354	$	14,742

We track development expenses that are directly attributable to our clinical development candidates by phase of clinical development. Such development expenses include third-party contract costs relating to formulation, manufacturing, preclinical studies and clinical trial activities. We allocate research and development salaries, benefits or indirect costs to our development candidates and we have included such costs in research and development expenses. All remaining research and development expenses are reflected in “Research and drug discovery” which represents early stage drug discovery programs. Such expenses include allocated employee salaries and related benefits, stock-based compensation, consulting and contracted services to supplement our in-house laboratory activities, laboratory consumables and allocated facility costs associated with these earlier stage programs.

At any given time, we typically have several active early stage research and drug discovery projects. Our internal resources, employees and infrastructure are not directly tied to any individual research or drug discovery project and are typically deployed across multiple projects. As such, we do not maintain information regarding these costs incurred for our early stage research and drug discovery programs on a project specific basis. We expect our research and development expenses to increase as we advance our development programs further and increase the number and size of our clinical trials. The process of conducting preclinical studies and clinical trials necessary to obtain regulatory approval is costly and time consuming. We or our partners may never succeed in achieving marketing approval for any of our drug candidates. The probability of success for each drug candidate may be affected by numerous factors, including preclinical data, clinical data, competition, manufacturing capability and commercial viability. Our strategy includes entering into additional partnerships with third parties for the development and commercialization of some of our independent drug candidates.

The successful development of our drug candidates is highly uncertain and may not result in approved products. Completion dates and completion costs can vary significantly for each drug candidate and are difficult to predict for each product. Given the uncertainty associated with clinical trial enrollments and the risks inherent in the development process, we are unable to determine the duration and completion costs of the current or future clinical trials of our drug candidates or if, or to what extent, we will generate revenues from the commercialization and sale of any of our drug candidates. We anticipate we will make determinations as to which programs to pursue and how much funding to direct to each program on an ongoing basis in response to the scientific and clinical success of each drug candidate, as well as ongoing assessment as to each drug candidate’s commercial potential. We will need to raise additional capital or may seek additional strategic alliances in the future in order to complete the development and commercialization of our drug candidates, including avacopan, CCX140 and CCX872.

General and administrative expenses

Total general and administrative expenses for the three months ended March 31, 2019, as compared to the same period in the prior year, were as follows (in thousands):

	Three Months Ended March 31,
	2019			2018
General and administrative expenses	$	5,501		$	4,660
Dollar increase	$	841
Percentage increase		18	%

23

General and administrative expenses consist primarily of salaries and related benefits, including stock-based compensation and travel expenses, in executive, finance, business and corporate development and other administrative functions. Other general and administrative expenses include allocated facility-related costs not otherwise included in research and development expenses, legal costs of pursuing patent protection of our intellectual property, and professional fees for auditing, tax, and legal services.

The increase from 2018 to 2019 for the three month period was primarily due to higher employee-related expenses, including those associated with our commercialization planning efforts, and higher professional fees.

We anticipate that our general and administrative expenses will increase substantially in the future primarily because of increased pre-commercial activities and personnel costs to support the potential launch of avacopan for the treatment of AAV in the United States.

Other income, net

Other income, net primarily consists of interest income earned on our marketable securities. Total other income, net for the three month period in 2019, as compared to the same period in the prior year, was as follows (in thousands):

	Three Months Ended March 31,
	2019			2018
Interest income	$	1,121		$	613
Interest expense		(542	)		(174	)
Total other income, net	$	579		$	439
Dollar increase	$	140
Percentage increase		32	%

The increase in total other income, net from 2018 to 2019 for the three month period was primarily due to increased interest income resulting from higher cash and investment balances and a higher return on the investment portfolio in 2019, partially offset by higher interest expense related to the loan and security agreement, or Credit Facility, with Hercules Capital, Inc., or Hercules. We expect interest expense to increase in the future as a result of higher debt balances in 2019 and additional amounts borrowed under the Credit Facility, if any, or if interest rates continue to rise.

Liquidity and Capital Resources

As of March 31, 2019, we had approximately $234.1 million in cash, cash equivalents and investments. The following table shows a summary of our cash flows for the three months ended March 31, 2019 and 2018 (in thousands):

	Three Months Ended March 31,
	2019			2018
Cash provided by (used in)
Operating activities	$	(18,286	)	$	40,948
Investing activities	$	(5,144	)	$	(51,073	)
Financing activities	$	74,675		$	655

Operating activities.    Net cash used in operating activities was $18.3 million for the three months ended March 31, 2019, compared to net cash provided by operating activities of $40.9 million for the same period in 2018. This decrease was primarily due to a higher net loss and changes in working capital items driven by the receipt of $50.0 million milestone payment in connection with the Avacopan Agreement and $10.0 million upfront commitment under the Avacopan Amendment in the 2018 period.

Investing activities.    Net cash used in investing activities for the periods presented primarily relate to the purchases, sales and maturities of investments used to fund the day-to-day needs of our business. Following the March 2019 issuance of common stock through our Equity Distribution Agreement, or EDA, with Piper Jaffray & Co., we invested the majority of our net proceeds received in short and long-term investments. For the same period in 2018, the use of cash in investing activities presented represents the investment of funds received under the Avacopan Agreement, as amended, and the related letter agreements.

Financing activities.    Net cash provided by financing activities was $74.7 million for the three months ended March 31, 2019, compared to $0.7 million for the same period in 2018. Net cash provided by financing activities for the three months ended March 31, 2019 included net proceeds of $73.3 million from the issuance of common stock under the EDA. Net cash provided by financing activities for both periods presented included proceeds from the exercise of stock options and cash used for tendered ChemoCentryx, Inc. common stock to satisfy employee tax withholding requirements upon vesting of restricted stock units.

24

In December 2017, we entered into the Credit Facility with Hercules, under which we may borrow up to $50.0 million in three tranches, subject to certain terms and conditions. As of March 31, 2019, we had borrowed $20.0 million under the Credit Facility, with $25.0 million remaining available, subject to Hercules’ approval, through June 15, 2019. We intend to use the net proceeds from the Credit Facility for general corporate purposes, which may include the repayment of debt and working capital. We were in compliance with all loan covenants as of March 31, 2019. See “Note 6. Long-term Debt” in the Notes to Condensed Consolidated Financial Statements included in Item 1 of this Quarterly Report on Form 10-Q for additional information regarding our borrowings.

As of March 31, 2019, we had approximately $234.1 million in cash, cash equivalents and investments. We believe that our available cash, cash equivalents and investments will be sufficient to fund our anticipated level of operations for at least 12 months following our financial statement issuance date, May 6, 2019. However, our forecast of the period of time through which our financial resources will be adequate to support our operations is a forward-looking statement that involves risks and uncertainties, and actual results could vary materially.

Our future capital requirements are difficult to forecast and will depend on many factors, including:

• the terms and timing of any other collaborative, licensing and other arrangements that we may establish;

• the initiation, progress, timing and completion of preclinical studies and clinical trials for our drug candidates and potential drug candidates;

• the number and characteristics of drug candidates that we pursue;

• the progress, costs and results of our clinical trials;

• the outcome, timing and cost of regulatory approvals;

• delays that may be caused by changing regulatory approvals;

• the cost and timing of hiring new employees to support continued growth;

• the costs involved in filing and prosecuting patent applications and enforcing and defending patent claims;

• the cost and timing of procuring clinical and commercial supplies of our drug candidates;

• the cost and timing of establishing sales, marketing and distribution capabilities; and

• the extent to which we acquire or invest in businesses, products or technologies.

Contractual Obligations and Commitments

There have been no material changes outside the ordinary course of our business to the contractual obligations we reported in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed with the SEC on March 11, 2019.

Recent Accounting Pronouncements

See “Note 2. Summary of Significant Accounting Policies” in the Notes to Condensed Consolidated Financial Statements included in Item 1 of this Quarterly Report on Form 10-Q for a full description of recently issued accounting pronouncements, including the respective expected dates of adoption and effects on our consolidated financial position and results of operations.

25

Item 3. Quantitative and Qualitative Disclosures About Market Risk

Our market risks at March 31, 2019 have not changed significantly from those discussed in “Item 7A. Quantitative and Qualitative Disclosures About Market Risk” of our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed with the SEC on March 11, 2019, other than the following:

Advances under the Credit Facility bear an interest rate equal to the greater of (i) 8.05% plus the prime rate as reported from time to time in The Wall Street Journal minus 4.75%, and (ii) 8.05%. We are affected by market risk exposure primarily through the effect of changes in interest rates on amounts payable under the Credit Facility. At March 31, 2019, borrowings under the Credit Facility totaled $20.0 million with an interest rate of 8.80%. We are obligated to make interest-only payments through July 1, 2021, at which point we will then be obligated to repay the principal balance and interest on the advances in equal monthly installments after the interest-only period and continuing through December 1, 2022. If the amount outstanding under the Credit Facility remained at this level for an entire year and interest rate increased by 1%, our annual interest expense would increase by an additional $200,000. See “Note 6. Long-term Debt” in the Notes to Condensed Consolidated Financial Statements included in Item 1 of this Quarterly Report on Form 10-Q for additional information regarding our borrowings.

Item 4. Controls and Procedures

Conclusions Regarding the Effectiveness of Disclosure Controls and Procedures

As of March 31, 2019, management, with the participation of our Disclosure Committee, performed an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) of the Exchange Act. Our disclosure controls and procedures are designed to ensure that information required to be disclosed in the reports we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms, and that such information is accumulated and communicated to our management, including the Chief Executive Officer and the Chief Financial and Administrative Officer, to allow timely decisions regarding required disclosures.

Any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objective. Based on this evaluation, our Chief Executive Officer and Chief Financial and Administrative Officer concluded that, as of March 31, 2019, the design and operation of our disclosure controls and procedures were effective.

Changes in Internal Control over Financial Reporting

There has been no change in our internal control over financial reporting during the three months ended March 31, 2019, that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

26

PART II. OTHER INFORMATION

Item 1. Legal Proceedings

Not Applicable.

Item 1A. Risk Factors

There have been no material changes to the risk factors included in “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed with the SEC on March 11, 2019.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

Not Applicable.

Item 3. Defaults Upon Senior Securities

Not Applicable.

Item 4. Mine Safety Disclosures

Not Applicable.

Item 5. Other Information

Not Applicable.

Item 6. Exhibits

A list of exhibits is set forth on the Exhibit Index immediately preceding the signature page of this Quarterly Report on Form 10-Q, and is incorporated herein by reference.

27

EXHIBIT INDEX

Exhibit Number	Description
3.2(1)	Amended and Restated Bylaws.
31.1	Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
31.2	Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
32.1	Certification of Chief Executive Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
32.2	Certification of Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
101	The following information from the Registrant’s Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2019, formatted in XBRL (Extensible Business Reporting Language): (i) Condensed Consolidated Balance Sheets, (ii) Condensed Consolidated Statements of Operations, (iii) Condensed Consolidated Statements of Comprehensive Loss, (iv) Condensed Consolidated Statements of Cash Flows, and (v) the Notes to Condensed Consolidated Financial Statements.

(1) Filed with the Registrant’s Current Report on Form 8-K filed on March 19, 2019, and incorporated herein by reference.

28

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	CHEMOCENTRYX, INC.
Date: May 6, 2019	/s/ Thomas J. Schall, Ph.D.
	Thomas J. Schall, Ph.D.
	President and Chief Executive Officer
	(Principal Executive Officer)
Date: May 6, 2019	/s/ Susan M. Kanaya
	Susan M. Kanaya
	Executive Vice President,
	Chief Financial and Administrative Officer and Secretary
	(Principal Financial Officer)
Date: May 6, 2019	/s/ Pui San Kwan
	Pui San Kwan
	Vice President, Finance
	(Principal Accounting Officer)

29

EX-31.1

Exhibit 31.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Thomas J. Schall, Ph.D., certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of ChemoCentryx, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

  /s/ Thomas J. Schall, Ph.D.

  Thomas J. Schall, Ph.D.

   Chief Executive Officer

Date: May 6, 2019

EX-31.2

Exhibit 31.2

CERTIFICATION OF CHIEF FINANCIAL OFFICER

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Susan M. Kanaya, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of ChemoCentryx, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

/s/ Susan M. Kanaya

Susan M. Kanaya

Chief Financial and Administrative Officer

Date: May 6, 2019

EX-32.1

Exhibit 32.1

CERTIFICATION

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

(Subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code)

In connection with the Quarterly Report on Form 10-Q of ChemoCentryx, Inc. (the “Company”) for the period ended March 31, 2019, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Thomas J. Schall, Ph.D., as Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: May 6, 2019	/s/ Thomas J. Schall, Ph.D.
	Thomas J. Schall, Ph.D.
	Chief Executive Officer

The foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing. A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

EX-32.2

Exhibit 32.2

CERTIFICATION

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

(Subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code)

In connection with the Quarterly Report on Form 10-Q of ChemoCentryx, Inc. (the “Company”) for the period ended March 31, 2019, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Susan M. Kanaya, as Chief Financial and Administrative Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: May 6, 2019	/s/ Susan M. Kanaya
	Susan M. Kanaya
	Chief Financial and Administrative Officer

The foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing. A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

XML

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2019	Apr. 30, 2019
Document and Entity Information [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Mar. 31, 2019
Document Fiscal Year Focus	2019
Document Fiscal Period Focus	Q1
Entity Registrant Name	ChemoCentryx, Inc.
Entity Central Index Key	0001340652
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Trading Symbol	CCXI
Entity Common Stock, Shares Outstanding		58,047,961
Entity Emerging Growth Company	false
Entity Small Business	false

XML

Condensed Consolidated Balance Sheets - USD ($)	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 79,333,000	$ 28,088,000
Short-term investments	142,777,000	148,896,000
Accounts receivable from related party	167,000	2,058,000
Prepaid expenses and other current assets	4,399,000	2,342,000
Total current assets	226,676,000	181,384,000
Property and equipment, net	1,441,000	1,536,000
Long-term investments	11,968,000	0
Operating Lease, Right-of-Use Asset	1,062,000	0
Other assets	210,000	390,000
Total assets	241,357,000	183,310,000
Current liabilities:
Accounts payable	1,293,000	966,000
Accrued and other current liabilities	12,865,000	12,969,000
Deferred revenue from related party	51,950,000	50,461,000
Total current liabilities	66,108,000	64,396,000
Long-term debt, net	19,714,000	19,689,000
Noncurrent deferred revenue from related party	74,451,000	84,100,000
Other non-current liabilities	445,000	387,000
Total liabilities	160,718,000	168,572,000
Commitments
Stockholders' equity:
Preferred stock, $0.001 par value, 10,000,000 shares authorized; no shares issued and outstanding	0	0
Common stock, $0.001 par value, 200,000,000 shares authorized; 57,725,915 and 50,652,238 shares issued and outstanding at March 31, 2019 and December 31, 2018, respectively	58,000	51,000
Additional paid-in capital	467,047,000	389,398,000
Note receivable	(16,000)	(16,000)
Accumulated other comprehensive loss	(4,000)	(198,000)
Accumulated deficit	(386,446,000)	(374,497,000)
Total stockholders' equity	80,639,000	14,738,000
Total liabilities and stockholders' equity	$ 241,357,000	$ 183,310,000

XML

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Mar. 31, 2019	Dec. 31, 2018
Statement of Financial Position [Abstract]
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	200,000,000	200,000,000
Common stock, shares issued	57,725,915	50,652,238
Common stock, shares outstanding	57,725,915	50,652,238

XML

Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenue:
Collaboration and license revenue from related party	$ 8,327	$ 9,546
Total revenue	8,327	9,546
Operating expenses:
Research and development	15,354	14,742
General and administrative	5,501	4,660
Total operating expenses	20,855	19,402
Loss from operations	(12,528)	(9,856)
Other income (expense):
Interest income	1,121	613
Interest expense	(542)	(174)
Total other income, net	579	439
Net loss	$ (11,949)	$ (9,417)
Basic and diluted net loss per common share	$ (0.23)	$ (0.19)
Shares used to compute basic and diluted net loss per common share	52,395	48,853

XML

Condensed Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Statement of Comprehensive Income [Abstract]
Net loss	$ (11,949)	$ (9,417)
Unrealized gain (loss) on available-for-sale securities	194	(183)
Comprehensive loss	$ (11,755)	$ (9,600)

XML

Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Note Receivable [Member]	Accumulated Other Comprehensive Loss [Member]	Accumulated Deficit [Member]
Beginning Balance at Dec. 31, 2017	$ 79,267	$ 49	$ 368,553	$ (16)	$ (119)	$ (289,200)
Beginning Balance, shares at Dec. 31, 2017		48,837,060
Net loss	(9,417)					(9,417)
Adoption of ASC Topic 606, Revenue from Contracts with Customers	(47,331)					(47,331)
Unrealized gain / (loss) on investments	(183)				(183)
Issuance of common stock under equity incentive plans	1,128		1,128
Issuance of common stock under equity incentive plans, shares		313,886
Repurchased shares upon vesting of restricted stock units for tax withholdings	(473)		(473)
Repurchased shares upon vesting of restricted stock units for tax withholdings, shares		(79,585)
Employee stock-based compensation	2,206		2,206
Compensation expense related to options granted to consultants	335		335
Ending Balance at Mar. 31, 2018	25,532	$ 49	371,749	(16)	(302)	(345,948)
Ending Balance, shares at Mar. 31, 2018		49,071,361
Beginning Balance at Dec. 31, 2018	$ 14,738	$ 51	389,398	(16)	(198)	(374,497)
Beginning Balance, shares at Dec. 31, 2018	50,652,238	50,652,238
Net loss	$ (11,949)					(11,949)
Unrealized gain / (loss) on investments	194				194
Issuance of common stock through Equity Distribution Agreement, net of issuance costs (Note 9)	$ 73,276	$ 6	73,270
Issuance of common stock through Equity Distribution Agreement, net of issuance costs (Note 9), shares	6,491,196	6,491,196
Issuance of common stock under equity incentive plans	$ 2,852	$ 1	2,851
Issuance of common stock under equity incentive plans, shares		690,100
Repurchased shares upon vesting of restricted stock units for tax withholdings	(1,174)		(1,174)
Repurchased shares upon vesting of restricted stock units for tax withholdings, shares		(107,619)
Employee stock-based compensation	2,662		2,662
Compensation expense related to options granted to consultants	40		40
Ending Balance at Mar. 31, 2019	$ 80,639	$ 58	$ 467,047	$ (16)	$ (4)	$ (386,446)
Ending Balance, shares at Mar. 31, 2019	57,725,915	57,725,915

XML

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands		3 Months Ended
		Mar. 31, 2019	Mar. 31, 2018
Operating activities
Net loss		$ (11,949)	$ (9,417)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Stock-based compensation		2,702	2,541
Depreciation of property and equipment		141	111
Amortization of right-of-use assets		239
Noncash interest income, net		(436)	(366)
Changes in assets and liabilities:
Accounts receivable due from related party		1,891	49,392
Prepaids and other current assets		(1,778)	(83)
Other assets		180	32
Accounts payable		327	(951)
Other liabilities		(1,443)	(1,372)
Deferred revenue from related party		(8,160)	1,061
Net cash provided by (used in) operating activities		(18,286)	40,948
Investing activities
Purchases of property and equipment, net		(46)	(32)
Purchases of investments		(75,235)	(77,941)
Sales of investments		4,967
Maturities of investments		65,170	26,900
Net cash used in investing activities		(5,144)	(51,073)
Financing activities
Proceeds from issuance of common stock		73,276
Proceeds from exercise of stock options		2,573	1,128
Employees' tax withheld and paid for restricted stock units		(1,174)	(473)
Net cash provided by financing activities		74,675	655
Net increase (decrease) in cash and cash equivalents		51,245	(9,470)
Cash and cash equivalents at beginning of period		28,088	40,020
Cash and cash equivalents at end of period		79,333	30,550
Supplemental disclosures of cash flow information
Cash paid for interest		422	$ 70
Right-of-use assets obtained in exchange for lease obligations	[1]	$ 1,301

[1] Amounts for the three months ended March 31, 2019 include the transition adjustment for the adoption of Topic 842.

XML

Description of Business

3 Months Ended

Mar. 31, 2019

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Description of Business

1. Description of Business

ChemoCentryx, Inc. (the Company) commenced operations in 1997. The Company is a clinical-stage biopharmaceutical company focused on developing new medications targeted at inflammatory disorders, autoimmune diseases and cancer. The Company’s principal operations are in the United States and it operates in one segment.

Unaudited Interim Financial Information

The financial information filed is unaudited. The Condensed Consolidated Financial Statements included in this report reflect all adjustments (consisting only of normal recurring adjustments) that the Company considers necessary for the fair statement of the results of operations for the interim periods covered and of the financial condition of the Company at the date of the interim balance sheet. The December 31, 2018 Condensed Consolidated Balance Sheet was derived from audited financial statements. The results for interim periods are not necessarily indicative of the results for the entire year or any other interim period. The Condensed Consolidated Financial Statements should be read in conjunction with the Company’s financial statements and the notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2018 filed with the Securities and Exchange Commission on March 11, 2019.

XML

Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2019

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

2. Summary of Significant Accounting Policies

Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States (GAAP) requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from these estimates.

Concentration of Credit Risk

The Company invests in a variety of financial instruments and, by its policy, limits the amount of credit exposure with any one issuer, industry or geographic area.

Accounts receivable are typically unsecured and are concentrated in the pharmaceutical industry and government sector. Accordingly, the Company may be exposed to credit risk generally associated with pharmaceutical companies and government funded entities. The Company has not historically experienced any significant losses due to concentration of credit risk.

Accounts receivable consists of the following (in thousands):

	March 31, 2019		December 31, 2018
Vifor (International) Ltd., and/or its affiliates, or collectively, Vifor	$	167	$	2,058

Net Loss Per Share

Basic net loss per common share is computed by dividing net loss attributable to common stockholders by the weighted-average number of common shares outstanding during the period, without consideration for common stock equivalents.

Diluted net loss per share is computed by dividing net loss attributable to common stockholders by the sum of the weighted-average number of common shares outstanding and dilutive common stock equivalent shares outstanding for the period. The Company’s potentially dilutive common stock equivalent shares, which include incremental common shares issuable upon (i) the exercise of outstanding stock options and warrants, (ii) vesting of restricted stock units (RSUs) and restricted stock awards (RSAs), and (iii) the purchase from contributions to the 2012 Employee Stock Purchase Plan (the ESPP), (calculated based on the treasury stock method), are only included in the calculation of diluted net loss per share when their effect is dilutive.

For the three months ended March 31, 2019 and 2018, the following potentially dilutive securities were excluded from the calculation of diluted net loss per share due to their anti-dilutive effect:

	Three Months Ended March 31,
	2019		2018
Options to purchase common stock, including purchases from contributions to ESPP		11,073,806		11,824,877
Restricted stock units		374,352		459,682
Restricted stock awards		27,278		85,431
Warrants to purchase common stock		150,000		150,000
		11,625,436		12,519,990

Comprehensive Loss

Comprehensive loss comprises net loss and other comprehensive loss. For the periods presented, other comprehensive loss consists of unrealized gains and losses on the Company’s available-for-sale securities. For the three months ended March 31, 2019, amounts reclassified from accumulated other comprehensive loss to net loss for unrealized gains (losses) on available-for-sale securities were not significant, and were recorded as part of other income, net in the Condensed Consolidated Statements of Operations. For the three months ended March 31, 2018, there were no sales of investments and therefore there were no reclassifications.

Leases

The Company determines if an arrangement includes a lease at inception. Operating leases are included in operating lease right-of-use (ROU) assets, accrued and other current liabilities and other non-current liabilities on the Company’s Condensed Consolidated Balance Sheets. Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at commencement date. The Company uses the incremental borrowing rate based on the information available at lease commencement date in determining the present value of future payments. The operating lease ROU asset also excludes lease incentives. The Company’s lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise any such options. Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term. The Company has elected not to apply the recognition requirements for short-term leases. For lease agreements with lease and non-lease components, the Company generally accounts for them separately.

Recent Accounting Pronouncements

In February 2016, the Financial Accounting Standard Board (FASB) issued Accounting Standards Update (ASU) No. 2016-02, Leases (Topic 842). The new standard requires the Company to recognize the assets and liabilities that arise from leases on the balance sheet and disclose qualitative and quantitative information about its leasing arrangements. On January 1, 2019, the Company adopted this new standard using the modified retrospective approach in accordance with Leases – Targeted Improvements (ASU No. 2018-11). The Company elected the package of practical expedients permitted under the transition guidance within ASU No. 2018-11, which among other things, allowed the Company to carry forward the historical lease classification of those leases in place as of January 1, 2019. Results for the three months ended March 31, 2019 are presented under Topic 842. Prior period amounts have not been adjusted and continue to be reported in accordance with the Company’s historical accounting under previous lease guidance, ASC Topic 840, Leases (Topic 840).

The impact of the adoption of Topic 842 on the accompanying Condensed Consolidated Balance Sheet as of January 1, 2019 was as follows (in thousands):

	December 31, 2018		Adjustments Due to the Adoption of Topic 842		January 1, 2019
Balance Sheet
Assets:
Operating lease right-of-use assets	$	—	$	1,301	$	1,301
Liabilities:
Operating lease liabilities:
Accrued and other current liabilities (1)		12,969		955		13,924
Other non-current liabilities (2)		387		346		733

(1) Includes deferred rent and current portion of operating lease liabilities

(2) Includes deferred rent and non-current portion of operating lease liabilities

In June 2016, the FASB issued ASU 2016-13, Financial Instruments – Credit Losses: Measurement of Credit Losses on Financial Instruments. The new standard replaces the incurred loss impairment methodology under the current standard with a methodology that reflects expected credit losses and requires consideration of a broader range of reasonable and supportable information to inform credit loss estimates. The Company will be required to use a forward-looking expected credit loss model for accounts receivables and other financial instruments. Credit losses relating to available-for-sale debt securities will also be recorded through an allowance for credit losses rather than as a reduction in the amortized cost basis of the securities. The new standard will be effective for the Company on January 1, 2020, with early adoption permitted on January 1, 2019. The Company is currently evaluating the impact of the adoption of this standard on its financial statements and does not expect the adoption of this accounting guidance to have a material impact on the consolidated financial statements.

In June 2018, the FASB issued ASU No. 2018-07, Compensation – Stock Compensation (Topic 718). The new standard simplifies the accounting for share-based payments to nonemployees by aligning it with the accounting for share-based payments to employees, with certain exceptions. The Company adopted this new standard on January 1, 2019. The adoption of this accounting guidance did not have a material impact on the consolidated financial statements.

The Company has reviewed other recent accounting pronouncements and concluded they are either not applicable to the business or that no material effect is expected on the consolidated financial statements as a result of future adoption.

In August 2018, the SEC adopted amendments to certain disclosure requirements in Securities Act Release No. 33-10532, Disclosure Update and Simplification. These amendments eliminated, modified, or integrated into other SEC requirements certain disclosure rules. Among the amendments was the requirement to present an analysis of changes in stockholders’ equity in the interim financial statements included in quarterly reports on Form 10-Q. The analysis, which can be presented as a footnote or separate statement, is required for the current and comparative quarter and year-to-date interim periods. The amendments became effective for the Company in its interim financial statements for the quarter ended March 31, 2019. The adoption of these SEC amendments did not have a material effect on the Company’s financial position, results of operations, cash flows or stockholders’ equity.

XML

Cash Equivalents and Investments

3 Months Ended

Mar. 31, 2019

Investments, Debt and Equity Securities [Abstract]

Cash Equivalents and Investments

3. Cash Equivalents and Investments

The amortized cost and fair value of cash equivalents and investments at March 31, 2019 and December 31, 2018 were as follows (in thousands):

	March 31, 2019
	Amortized		Gross Unrealized					Fair
	Cost		Gains		Losses			Value
Money market fund	$	71,368	$	—	$	—		$	71,368
U.S. treasury securities		35,798		12		(1	)		35,809
Commercial paper		49,638		—		—			49,638
Asset-backed securities		27,147		6		—			27,153
Corporate debt securities		46,046		20		(41	)		46,025
Total available-for-sale securities	$	229,997	$	38	$	(42	)	$	229,993
Classified as:
Cash equivalents								$	75,248
Short-term investments									142,777
Long-term investments									11,968
Total available-for-sale securities								$	229,993

	December 31, 2018
	Amortized		Gross Unrealized					Fair
	Cost		Gains		Losses			Value
Money market fund	$	22,073	$	—	$	—		$	22,073
U.S. treasury securities		23,013		—		(13	)		23,000
Commercial paper		45,683		—		—			45,683
Asset-backed securities		29,127		—		(34	)		29,093
Corporate debt securities		55,228		—		(151	)		55,077
Total available-for-sale securities	$	175,124	$	—	$	(198	)	$	174,926
Classified as:
Cash equivalents								$	26,030
Short-term investments									148,896
Long-term investments									—
Total available-for-sale securities								$	174,926

Cash equivalents in the tables above exclude cash of $4.1 million and $2.1 million as of March 31, 2019 and December 31, 2018, respectively. All available-for-sale securities held as of March 31, 2019 had contractual maturities of less than two years. There have been no significant realized gains or losses on available-for-sale securities for the periods presented. The Company applies the specific identification method to determine the cost basis of the securities sold. No significant available-for-sale securities held as of March 31, 2019 have been in a continuous unrealized loss position for more than 12 months. As of March 31, 2019, unrealized losses on available-for-sale investments are not attributed to credit risk and are considered to be temporary. The Company believes that it is more-likely-than-not that investments in an unrealized loss position will be held until maturity or the recovery of the cost basis of the investment. The Company believes it has no other-than-temporary impairments on its securities because it does not intend to sell these securities and it believes it is not more likely than not that it will be required to sell these securities before the recovery of their amortized cost basis. To date, the Company has not recorded any impairment charges on marketable securities related to other-than-temporary declines in market value.

XML

Fair Value Measurements

3 Months Ended

Mar. 31, 2019

Fair Value Disclosures [Abstract]

Fair Value Measurements

4. Fair Value Measurements

The Company determines the fair value of financial assets and liabilities using three levels of inputs as follows:

Level 1—Inputs which include quoted prices in active markets for identical assets and liabilities.

Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

Recurring Fair Value Measurements

The Company’s financial assets subject to fair value measurements on a recurring basis and the level of inputs used in such measurements were as follows as of March 31, 2019 and December 31, 2018 (in thousands):

	March 31, 2019
Description	Level 1		Level 2		Level 3		Total
Money market fund	$	71,368	$	—	$	—	$	71,368
U.S. treasury securities		—		35,809		—		35,809
Commercial paper		—		49,638		—		49,638
Asset-backed securities		—		27,153		—		27,153
Corporate debt securities		—		46,025		—		46,025
Total assets	$	71,368	$	158,625	$	—	$	229,993

	December 31, 2018
Description	Level 1		Level 2		Level 3		Total
Money market fund	$	22,073	$	—	$	—	$	22,073
U.S. treasury securities		—		23,000		—		23,000
Commercial paper		—		45,683		—		45,683
Asset-backed securities		—		29,093		—		29,093
Corporate debt securities		—		55,077		—		55,077
Total assets	$	22,073	$	152,853	$	—	$	174,926

During the three months ended March 31, 2019, there were no transfers between Level 1 and Level 2 financial assets. When the Company uses observable market prices for identical securities that are traded in less active markets, the Company classifies its marketable debt instruments as Level 2. When observable market prices for identical securities are not available, the Company prices its marketable debt instruments using non-binding market consensus prices that are corroborated with observable market data; quoted market prices for similar instruments; or pricing models, such as a discounted cash flow model, with all significant inputs derived from or corroborated with observable market data. Non-binding market consensus prices are based on the proprietary valuation models of pricing providers or brokers. These valuation models incorporate a number of inputs, including non-binding and binding broker quotes; observable market prices for identical or similar securities; and the internal assumptions of pricing providers or brokers that use observable market inputs and, to a lesser degree, unobservable market inputs. The Company corroborates non-binding market consensus prices with observable market data using statistical models when observable market data exists. The discounted cash flow model uses observable market inputs, such as LIBOR-based yield curves, currency spot and forward rates, and credit ratings.

Other Fair Value Measurements

The carrying amount and estimated fair value of financial instruments not recorded at fair value at March 31, 2019 and December 31, 2018 were as follows (in thousands):

	March 31, 2019				December 31, 2018
	Carrying Amount		Estimated Fair Value		Carrying Amount		Estimated Fair Value
Long-term debt, net (1)	$	19,714	$	19,954	$	19,689	$	19,847

(1) Carrying amounts of long-term debt were net of unamortized debt discounts of $286,000 and $311,000 as of March 31, 2019 and December 31, 2018, respectively.

The fair value of the Company’s long-term debt is estimated using the net present value of future debt payments, discounted at an interest rate that is consistent with market interest rates, which is a Level 2 input.

XML

Accrued and Other Current Liabilities

3 Months Ended

Mar. 31, 2019

Payables and Accruals [Abstract]

Accrued And Other Liabilities Current Disclosure [Text Block]

5. Accrued and Other Current Liabilities

Accrued and other current liabilities consist of the following (in thousands):

	March 31, 2019		December 31, 2018
Research and development related	$	8,220	$	8,466
Compensation related		1,460		2,767
Consulting and professional services		779		811
Current portion of operating lease liability		1,357		—
Other		1,049		925
	$	12,865	$	12,969

XML

Long-term Debt

3 Months Ended

Mar. 31, 2019

Debt Disclosure [Abstract]

Long-term Debt

6. Long-term Debt

On December 28, 2017 (the Closing Date), the Company entered into a Loan and Security Agreement with Hercules Capital, Inc. (Hercules) which the Company amended in December 2018, pursuant to which term loans in an aggregate principal amount of up to $50.0 million (the Credit Facility) are available to the Company in three tranches, subject to certain terms and conditions. As of March 31, 2019, the Company had borrowed $20.0 million under the Credit Facility with up to $25.0 million remaining available for future borrowing, subject to Hercules’ approval, through June 15, 2019.

Advances under the Credit Facility bear an interest rate equal to the greater of either (i) 8.05% plus the prime rate as reported from time to time in The Wall Street Journal minus 4.75%, and (ii) 8.05%. At March 31, 2019, the interest rate on the outstanding borrowings under the Credit Facility was 8.80%. For advances made under the first and second tranches, the Company will make interest-only payments through July 1, 2021, and will then repay the principal balance and interest on the advances in equal monthly installments after the interest-only period and continuing through December 1, 2022. For advances made under the third tranche, the Company will make interest-only payments for the first 30 months, and will then repay the principal balance and interest on the advances in equal monthly installments after the interest-only period with each advance repaid 48 months after it is drawn.

The Company may prepay advances under the Credit Facility, in whole or in part, at any time, subject to a prepayment charge equal to: (a) 1.5% of the amount so prepaid, if such prepayment occurs during the second year following the Closing Date; and (b) 1.0% of the amount so prepaid, if such prepayment occurs after the second year following the Closing Date. The Credit Facility is secured by substantially all of the Company’s assets, excluding intellectual property.

In addition, Hercules has the right to participate, in an amount up to $2.0 million, in any subsequent equity financing broadly marketed to multiple investors in an amount greater than $20.0 million. The Credit Facility also includes customary affirmative restrictions on the payment of dividends and negative covenants, and events of default, the occurrence and continuance of which provide Hercules with the right to demand immediate repayment of all principal and unpaid interest under the Credit Facility, and to exercise remedies against the Company and the collateral securing the Credit Facility. The Company was in compliance with all loan covenants for all periods presented.

The Company will pay an end-of-term charge for each tranche which will occur on the earliest of (i) the applicable tranche maturity date; (ii) the date that the Company prepays all of the outstanding principal under each tranche in full, or (iii) the date the loan payments are accelerated due to an event of default. For the first and second tranches, the end of term charge is $0.9 million and $0.3 million, respectively. In the case of the third tranche, the charge is 6.25% of the aggregate amount of the advances applicable to such tranche.

In addition, the Company pays a commitment charge of 1% of the advances made under the Credit Facility, with a minimum charge of $162,500 paid on the Closing Date. Also, the Company reimbursed Hercules for costs incurred related to the Credit Facility. These charges were recorded as discounts to the carrying value of the loan and are amortized over the term of the loan using the effective interest method.

As of March 31, 2019, the Company had outstanding borrowings under the Credit Facility of $19.7 million, net of discounts of $0.3 million. Future minimum principal payments, which exclude the end of term charge, related to the Credit Facility as of March 31, 2019 are as follows (in thousands):

	Amounts
Year ending December 31:
Remaining of fiscal year 2019	$	—
2020		—
2021		6,363
2022		13,637
Total minimum payments		20,000
Less: amount representing debt discount		(286	)
Present value of remaining debt payments		19,714
Less: current portion		—
Noncurrent portion	$	19,714

XML

Commitments

3 Months Ended

Mar. 31, 2019

Commitments and Contingencies Disclosure [Abstract]

Commitments

7. Commitments

Operating Leases

As described further in “Note 2. Summary of Significant Accounting Policies”, the Company adopted Topic 842 as of January 1, 2019. The comparative information has not been restated and continues to be reported under the accounting standards in effect for those periods.

In May 2004, the Company entered into a noncancelable operating lease for its current office and primary research facility located in Mountain View, California. The Company received a discounted lease rate during the first year of the agreement. In August 2012, the Company entered into an amendment to the lease agreement for the same facility to extend the term through April 2019. In April 2017, the Company entered into a second amendment to the lease agreement for the same facility to extend the term of the lease through April 2020.

The balance sheet classification of the Company’s operating lease liabilities was as follows (in thousands):

	March 31, 2019		December 31, 2018
Accrued and other current liabilities (1)	$	1,357	$	244
Other non-current liabilities (2)		124		143
Total lease liabilities	$	1,481	$	387

(1) Includes current portion of operating lease liabilities as of March 31, 2019 and deferred rent as of December 31, 2018

(2) Includes non-current portion of operating lease liabilities as of March 31, 2019 and deferred rent as of December 31, 2018

The component of lease costs, which was included in operating expenses in the Company’s Condensed Consolidated Statements of Operations, was as follows (in thousands):

	Three Months Ended March 31,
	2019		2018
Operating lease cost	$	268	$	268

Cash paid for amounts included in the measurement of lease liabilities for the three months ended March 31, 2019 was $236,000 and was included in net cash used in operating activities in the Company’s Condensed Consolidated Statements of Cash Flows.

Future minimum lease payments under all noncancelable operating leases as of March 31, 2019 are as follows (in thousands):

	Operating leases
Year ending December 31:
Remaining of fiscal year 2019	$	1,080
2020		501
Total minimum payments		1,581
Less: interest		(100	)
Present value of lease liabilities	$	1,481

As of March 31, 2019, the weighted-average remaining lease term was 1.1 years and the weighted-average operating discount rate used to determine the operating lease liability was 11.0%.

XML

Related-Party Transactions

3 Months Ended

Mar. 31, 2019

Related Party Transactions [Abstract]

Related-Party Transactions

8. Related-Party Transactions

Vifor

Vifor held 10,676,825 shares of the Company’s common stock as of March 31, 2019. The Company has collaboration agreements with Vifor: the Avacopan Agreements and the CCX140 Agreements (each as described below). See “Note 2. Summary of Significant Accounting Policies – Concentration of Credit Risk” for additional information on accounts receivable balance due from Vifor.

Avacopan Agreements

In May 2016, the Company entered into an exclusive collaboration and license agreement with Vifor pursuant to which the Company granted Vifor exclusive rights to commercialize avacopan in Europe and certain other markets (the Avacopan Agreement). Avacopan is the Company’s lead drug candidate for the treatment of patients with anti-neutrophil cytoplasmic auto-antibody associated vasculitis (AAV) and other rare diseases. The Avacopan Agreement also provided Vifor with an exclusive option to negotiate during 2016 a worldwide license agreement for one of the Company’s other drug candidates, CCX140, an orally-administered inhibitor of the chemokine receptor known as CCR2. In connection with the Avacopan Agreement, the Company received a non-refundable upfront payment of $85.0 million, comprising $60.0 million in cash and $25.0 million in the form of an equity investment to purchase 3,333,333 shares of the Company’s common stock at a price of $7.50 per share.

In February 2017, Vifor and the Company expanded the Vifor territories under the Avacopan Agreement to include all markets outside the United States and China (the Avacopan Amendment). In connection with this February 2017 arrangement, the Company received a $20.0 million upfront payment for the expanded rights. In June 2018, Vifor and the Company further expanded the Vifor territories under the Avacopan Agreement to provide Vifor with exclusive commercialization rights in China (the Avacopan Letter Agreement, and together with the Avacopan Agreement and the Avacopan Amendment, the Avacopan Agreements). The Company retains control of ongoing and future development of avacopan (other than country-specific development in the licensed territories) and all commercialization rights to avacopan in the United States. In consideration for the Avacopan Letter Agreement, the Company received a $5.0 million payment for the expanded rights.

Upon achievement of certain regulatory and commercial milestones with avacopan, the Company will receive additional payments of up to $460.0 million under the Avacopan Agreement. In addition, the Company will receive royalties, with rates ranging from the low teens to the mid-twenties, on future potential net sales of avacopan by Vifor in the licensed territories. In December 2017, the Company achieved a $50.0 million regulatory milestone when the European Medicines Agency (EMA) validated the Company’s Conditional marketing authorisation (CMA) application for avacopan for the treatment of AAV.

The Company identified the following material promises under the Avacopan Agreements: (1) the license related to avacopan; (2) the development and regulatory services for the submission of the marketing authorisation application (MAA); and (3) an exclusive option to negotiate a worldwide license agreement for CCX140, which expired in 2016. The Company considered that the license has standalone functionality and is capable of being distinct. However, the Company determined that the license is not distinct from the development and regulatory services within the context of the agreement because Vifor is dependent on the Company to execute the development and regulatory activities in order for Vifor to benefit from the license. As such, the license is combined with the development and regulatory services into a single performance obligation. The exclusive option related to CCX140 is a separate performance obligation and the Company determined that its transaction price is not material. As such, the transaction price under this arrangement is allocated to the license and the development and regulatory services.

As of March 31, 2019, the transaction price of $153.0 million consists of the following:

• $78.0 million upfront payment under the May 2016 Avacopan Agreement. Of the total $85.0 million upfront payment received under the May 2016 Avacopan Agreement, $7.0 million was allocated to the issuance of 3,333,333 shares of the Company’s common stock valued at $2.10 per share, the closing stock price on the effective date of the agreement, May 9, 2016. The remaining $78.0 million was allocated to the transaction price under this arrangement;

• $20.0 million upfront payment under the February 2017 Avacopan Amendment;

• $50.0 million regulatory milestone payment achieved upon the validation of the Company’s CMA application by the EMA, for avacopan for the treatment of AAV in December 2017; and

• $5.0 million non-refundable upfront payment under the Avacopan Letter Agreement.

The Company will re-evaluate the transaction price in each reporting period and as uncertain events are resolved or other changes in circumstances occur.

The Company determined that the combined performance obligation will be performed over the duration of the contract, which began on the effective date of May 9, 2016 and ends upon completion of development and regulatory services. The Company uses a cost-based input method to measure proportional performance and to calculate the corresponding amount of revenue to recognize. The Company believes this is the best measure of progress because other measures do not reflect how the Company transfers its performance obligation to Vifor. In applying the cost-based input method of revenue recognition, the Company measures actual costs incurred relative to budgeted costs to fulfill the combined performance obligation. These costs consist primarily of third-party contract costs. Revenue is recognized based on actual costs incurred as a percentage of total budgeted costs as the Company completes its performance obligations.

For the three months ended March 31, 2019 and 2018, the Company recognized $6.6 million and $8.2 million of collaboration and license revenue under the Avacopan Agreements, respectively.

CCX140 Agreements

In December 2016, the Company entered into a second collaboration and license agreement with Vifor pursuant to which the Company granted Vifor exclusive rights to commercialize CCX140 (the CCX140 Agreement) in markets outside the United States and China. CCX140 is an orally-administered inhibitor of the chemokine receptor known as CCR2. The Company retains marketing rights in the United States and China, while Vifor has commercialization rights in the rest of the world. Pursuant to the CCX140 Agreement, the Company is responsible for the clinical development of CCX140 in rare renal diseases and is reimbursed for Vifor’s equal share of such development cost. Vifor retains an option to solely develop and commercialize CCX140 in more prevalent forms of chronic kidney disease (CKD). Should Vifor later exercise the CKD option, the Company would receive co-promotion rights for CKD in the United States. Under the terms of the CCX140 Agreement, the Company received a non-refundable upfront payment of $50.0 million in 2017.

In June 2018, the Company and Vifor entered into a letter agreement to expand Vifor’s rights to include the right to exclusively commercialize CCX140 in China (the CCX140 Letter Agreement). In connection with the CCX140 Letter Agreement, the Company received a non-refundable payment of $5.0 million. The Company and Vifor also entered into an amendment to the CCX140 Agreement (the CCX140 Amendment, and together with the CCX140 Agreement and the CCX140 Letter Agreement, the CCX140 Agreements) to clarify the timing of certain payments with respect to development funding of the CCX140 program by Vifor, and the Company received a non-refundable payment of $11.5 million. The Company retains control of ongoing and future development of CCX140 (other than country-specific development in the licensed territories), and all commercialization rights to CCX140 in the United States.

Upon achievement of certain regulatory and commercial milestones with CCX140, the Company will receive additional payments of up to $625.0 million under the CCX140 Agreement. In addition, the Company will receive tiered royalties, with rates ranging from ten to the mid-twenties, on net sales of CCX140 in the licensed territories.

The Company identified the following material promises under the CCX140 Agreements: (1) the license related to CCX140; and (2) the development and regulatory services for the submission of the MAA. The Company considered that the license has standalone functionality and is capable of being distinct. However, the Company determined that the license is not distinct from the development and regulatory services within the context of the agreement because Vifor is dependent on the Company to execute the development and regulatory activities in order for Vifor to benefit from the license. As such, the license is combined with the development and regulatory services into a single performance obligation.

As of March 31, 2019, the transaction price of $113.5 million consists of the following:

• $50.0 million upfront payment under the CCX140 Agreement;

• $58.5 million of CCX140 development funding by Vifor; and

• $5.0 million non-refundable upfront payment under the CCX140 Letter Agreement.

The Company will re-evaluate the transaction price in each reporting period and as uncertain events are resolved or other changes in circumstances occur.

The Company determined that the combined performance obligation will be performed over the duration of the contract, which began on the effective date of December 22, 2016 and ends upon completion of development and regulatory services. The Company uses a cost-based input method to measure proportional performance and to calculate the corresponding amount of revenue to recognize. The Company believes this is the best measure of progress because other measures do not reflect how the Company transfers its performance obligation to Vifor. In applying the cost-based input method of revenue recognition, the Company measures actual costs incurred relative to budgeted costs to fulfill the combined performance obligation. These costs consist primarily of third-party contract costs. Revenue is recognized based on actual costs incurred as a percentage of total budgeted costs as the Company completes its performance obligations. For the three months ended March 31, 2019 and 2018, the Company recognized $1.7 million and $1.3 million of collaboration and license revenue under the CCX140 Agreements, respectively.

The following table presents the contract assets and liabilities for all of the Company’s revenue contracts as of the following dates (in thousands):

	March 31, 2019			December 31, 2018
Contract asset:
Accounts receivable	$	167		$	2,058
Contract liability:
Deferred revenue		(126,401	)		(134,561	)

During the three months ended March 31, 2019, the Company recognized the following revenue as a result of changes in the contract asset and the contract liability balances (in thousands):

	Three Months Ended March 31, 2019
Revenue recognized in the period from:
Amount included in contract liability at the beginning of the period	$	8,160
Performance obligations satisfied (or partially satisfied) in previous periods	$	(896	)

XML

Stockholders' Equity

3 Months Ended

Mar. 31, 2019

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Stockholders' Equity

9. Stockholders’ Equity

Stock Options

During the three months ended March 31, 2019, the Company had the following activities under its equity incentive plans:

	Available for Grant			Shares			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value
Balance at December 31, 2018		1,708,516			10,720,200		$	8.39
Shares authorized		2,000,000			—
Granted (1)		(1,529,886	)		1,384,133			11.44
Exercised (2)		107,619			(485,012	)		5.88
Forfeited and expired (3)		584,832			(578,165	)		6.85
Outstanding at March 31, 2019		2,871,081			11,041,156		$	8.96		6.40	$	55,107,905
Vested and expected to vest, net of estimated forfeiture at March 31, 2019					10,648,497		$	8.91		6.29	$	53,745,822
Exercisable at March 31, 2019					7,200,618		$	8.56		5.00	$	39,078,897

(1) The difference between shares granted in the number of shares available for grant and outstanding options represents the RSUs and RSAs granted for the period.

(2) Shares presented as available for grant represents shares repurchased for tax withholding upon vesting of RSUs.

(3) The difference between shares forfeited and expired in the number of shares available for grant and outstanding options represents the RSUs canceled during the period.

Restricted Stock

During the three months ended March 31, 2019, the activity for restricted stock is summarized as follows:

	Shares			Weighted Average Grant-Date Fair Value
Balance at December 31, 2018		467,632		$	8.47
Granted		145,753			11.23
Vested		(205,088	)		7.38
Canceled		(6,667	)		10.86
Unvested at March 31, 2019		401,630		$	9.99

Stock-based Compensation

Total stock-based compensation expense was $2.7 million and $2.5 million during the three months ended March 31, 2019 and 2018, respectively. As of March 31, 2019, $19.4 million, $2.7 million and $38,000 of total unrecognized compensation expenses associated with outstanding employee stock options, unvested restricted stock, and the ESPP, net of estimated forfeitures, were expected to be recognized over a weighted-average period of 2.74, 1.66 and 0.12 years, respectively.

Equity Distribution Agreement

In December 2018, the Company entered into an Equity Distribution Agreement (EDA), pursuant to which the Company may offer and sell, from time to time, shares of the Company’s common stock, par value $0.001 per share, having an aggregate offering price of up to $75.0 million. For the three months ended March 31, 2019, the Company sold 6,491,196 shares of its common stock pursuant to its EDA for net proceeds of $73.3 million. These sales fully exhausted the amount available under the EDA. Accordingly, no further sales will be made under the EDA.

XML

Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2019

Accounting Policies [Abstract]

Use of Estimates

Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States (GAAP) requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from these estimates.

Concentration of Credit Risk

Concentration of Credit Risk

The Company invests in a variety of financial instruments and, by its policy, limits the amount of credit exposure with any one issuer, industry or geographic area.

Accounts receivable are typically unsecured and are concentrated in the pharmaceutical industry and government sector. Accordingly, the Company may be exposed to credit risk generally associated with pharmaceutical companies and government funded entities. The Company has not historically experienced any significant losses due to concentration of credit risk.

Accounts receivable consists of the following (in thousands):

	March 31, 2019		December 31, 2018
Vifor (International) Ltd., and/or its affiliates, or collectively, Vifor	$	167	$	2,058

Net Loss Per Share

Net Loss Per Share

Basic net loss per common share is computed by dividing net loss attributable to common stockholders by the weighted-average number of common shares outstanding during the period, without consideration for common stock equivalents.

Diluted net loss per share is computed by dividing net loss attributable to common stockholders by the sum of the weighted-average number of common shares outstanding and dilutive common stock equivalent shares outstanding for the period. The Company’s potentially dilutive common stock equivalent shares, which include incremental common shares issuable upon (i) the exercise of outstanding stock options and warrants, (ii) vesting of restricted stock units (RSUs) and restricted stock awards (RSAs), and (iii) the purchase from contributions to the 2012 Employee Stock Purchase Plan (the ESPP), (calculated based on the treasury stock method), are only included in the calculation of diluted net loss per share when their effect is dilutive.

For the three months ended March 31, 2019 and 2018, the following potentially dilutive securities were excluded from the calculation of diluted net loss per share due to their anti-dilutive effect:

	Three Months Ended March 31,
	2019		2018
Options to purchase common stock, including purchases from contributions to ESPP		11,073,806		11,824,877
Restricted stock units		374,352		459,682
Restricted stock awards		27,278		85,431
Warrants to purchase common stock		150,000		150,000
		11,625,436		12,519,990

Comprehensive Loss

Comprehensive Loss

Comprehensive loss comprises net loss and other comprehensive loss. For the periods presented, other comprehensive loss consists of unrealized gains and losses on the Company’s available-for-sale securities. For the three months ended March 31, 2019, amounts reclassified from accumulated other comprehensive loss to net loss for unrealized gains (losses) on available-for-sale securities were not significant, and were recorded as part of other income, net in the Condensed Consolidated Statements of Operations. For the three months ended March 31, 2018, there were no sales of investments and therefore there were no reclassifications.

Lease, Policy

Leases

The Company determines if an arrangement includes a lease at inception. Operating leases are included in operating lease right-of-use (ROU) assets, accrued and other current liabilities and other non-current liabilities on the Company’s Condensed Consolidated Balance Sheets. Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at commencement date. The Company uses the incremental borrowing rate based on the information available at lease commencement date in determining the present value of future payments. The operating lease ROU asset also excludes lease incentives. The Company’s lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise any such options. Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term. The Company has elected not to apply the recognition requirements for short-term leases. For lease agreements with lease and non-lease components, the Company generally accounts for them separately.

Recent Accounting Pronouncements

Recent Accounting Pronouncements

In February 2016, the Financial Accounting Standard Board (FASB) issued Accounting Standards Update (ASU) No. 2016-02, Leases (Topic 842). The new standard requires the Company to recognize the assets and liabilities that arise from leases on the balance sheet and disclose qualitative and quantitative information about its leasing arrangements. On January 1, 2019, the Company adopted this new standard using the modified retrospective approach in accordance with Leases – Targeted Improvements (ASU No. 2018-11). The Company elected the package of practical expedients permitted under the transition guidance within ASU No. 2018-11, which among other things, allowed the Company to carry forward the historical lease classification of those leases in place as of January 1, 2019. Results for the three months ended March 31, 2019 are presented under Topic 842. Prior period amounts have not been adjusted and continue to be reported in accordance with the Company’s historical accounting under previous lease guidance, ASC Topic 840, Leases (Topic 840).

The impact of the adoption of Topic 842 on the accompanying Condensed Consolidated Balance Sheet as of January 1, 2019 was as follows (in thousands):

	December 31, 2018		Adjustments Due to the Adoption of Topic 842		January 1, 2019
Balance Sheet
Assets:
Operating lease right-of-use assets	$	—	$	1,301	$	1,301
Liabilities:
Operating lease liabilities:
Accrued and other current liabilities (1)		12,969		955		13,924
Other non-current liabilities (2)		387		346		733

(1) Includes deferred rent and current portion of operating lease liabilities

(2) Includes deferred rent and non-current portion of operating lease liabilities

In June 2016, the FASB issued ASU 2016-13, Financial Instruments – Credit Losses: Measurement of Credit Losses on Financial Instruments. The new standard replaces the incurred loss impairment methodology under the current standard with a methodology that reflects expected credit losses and requires consideration of a broader range of reasonable and supportable information to inform credit loss estimates. The Company will be required to use a forward-looking expected credit loss model for accounts receivables and other financial instruments. Credit losses relating to available-for-sale debt securities will also be recorded through an allowance for credit losses rather than as a reduction in the amortized cost basis of the securities. The new standard will be effective for the Company on January 1, 2020, with early adoption permitted on January 1, 2019. The Company is currently evaluating the impact of the adoption of this standard on its financial statements and does not expect the adoption of this accounting guidance to have a material impact on the consolidated financial statements.

In June 2018, the FASB issued ASU No. 2018-07, Compensation – Stock Compensation (Topic 718). The new standard simplifies the accounting for share-based payments to nonemployees by aligning it with the accounting for share-based payments to employees, with certain exceptions. The Company adopted this new standard on January 1, 2019. The adoption of this accounting guidance did not have a material impact on the consolidated financial statements.

The Company has reviewed other recent accounting pronouncements and concluded they are either not applicable to the business or that no material effect is expected on the consolidated financial statements as a result of future adoption.

In August 2018, the SEC adopted amendments to certain disclosure requirements in Securities Act Release No. 33-10532, Disclosure Update and Simplification. These amendments eliminated, modified, or integrated into other SEC requirements certain disclosure rules. Among the amendments was the requirement to present an analysis of changes in stockholders’ equity in the interim financial statements included in quarterly reports on Form 10-Q. The analysis, which can be presented as a footnote or separate statement, is required for the current and comparative quarter and year-to-date interim periods. The amendments became effective for the Company in its interim financial statements for the quarter ended March 31, 2019. The adoption of these SEC amendments did not have a material effect on the Company’s financial position, results of operations, cash flows or stockholders’ equity.

XML

Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2019

Accounting Policies [Abstract]

Summary of Accounts Receivable

Accounts receivable consists of the following (in thousands):

	March 31, 2019		December 31, 2018
Vifor (International) Ltd., and/or its affiliates, or collectively, Vifor	$	167	$	2,058

Potentially Dilutive Securities Excluded from Calculation of Diluted Net Income (Loss) per Share Due to Anti-Dilutive Effect

For the three months ended March 31, 2019 and 2018, the following potentially dilutive securities were excluded from the calculation of diluted net loss per share due to their anti-dilutive effect:

	Three Months Ended March 31,
	2019		2018
Options to purchase common stock, including purchases from contributions to ESPP		11,073,806		11,824,877
Restricted stock units		374,352		459,682
Restricted stock awards		27,278		85,431
Warrants to purchase common stock		150,000		150,000
		11,625,436		12,519,990

Schedule of Impact of Adoption on Consolidated Statement of Operations and Balance Sheet

The impact of the adoption of Topic 842 on the accompanying Condensed Consolidated Balance Sheet as of January 1, 2019 was as follows (in thousands):

	December 31, 2018		Adjustments Due to the Adoption of Topic 842		January 1, 2019
Balance Sheet
Assets:
Operating lease right-of-use assets	$	—	$	1,301	$	1,301
Liabilities:
Operating lease liabilities:
Accrued and other current liabilities (1)		12,969		955		13,924
Other non-current liabilities (2)		387		346		733

(1) Includes deferred rent and current portion of operating lease liabilities

(2) Includes deferred rent and non-current portion of operating lease liabilities

XML

Cash Equivalents and Investments (Tables)

3 Months Ended

Mar. 31, 2019

Investments, Debt and Equity Securities [Abstract]

Amortized Cost and Fair Value of Cash Equivalents and Investments

The amortized cost and fair value of cash equivalents and investments at March 31, 2019 and December 31, 2018 were as follows (in thousands):

	March 31, 2019
	Amortized		Gross Unrealized					Fair
	Cost		Gains		Losses			Value
Money market fund	$	71,368	$	—	$	—		$	71,368
U.S. treasury securities		35,798		12		(1	)		35,809
Commercial paper		49,638		—		—			49,638
Asset-backed securities		27,147		6		—			27,153
Corporate debt securities		46,046		20		(41	)		46,025
Total available-for-sale securities	$	229,997	$	38	$	(42	)	$	229,993
Classified as:
Cash equivalents								$	75,248
Short-term investments									142,777
Long-term investments									11,968
Total available-for-sale securities								$	229,993

	December 31, 2018
	Amortized		Gross Unrealized					Fair
	Cost		Gains		Losses			Value
Money market fund	$	22,073	$	—	$	—		$	22,073
U.S. treasury securities		23,013		—		(13	)		23,000
Commercial paper		45,683		—		—			45,683
Asset-backed securities		29,127		—		(34	)		29,093
Corporate debt securities		55,228		—		(151	)		55,077
Total available-for-sale securities	$	175,124	$	—	$	(198	)	$	174,926
Classified as:
Cash equivalents								$	26,030
Short-term investments									148,896
Long-term investments									—
Total available-for-sale securities								$	174,926

XML

Fair Value Measurements (Tables)

3 Months Ended

Mar. 31, 2019

Fair Value Disclosures [Abstract]

Fair Value Measurements of Company's Financial Assets

The Company’s financial assets subject to fair value measurements on a recurring basis and the level of inputs used in such measurements were as follows as of March 31, 2019 and December 31, 2018 (in thousands):

	March 31, 2019
Description	Level 1		Level 2		Level 3		Total
Money market fund	$	71,368	$	—	$	—	$	71,368
U.S. treasury securities		—		35,809		—		35,809
Commercial paper		—		49,638		—		49,638
Asset-backed securities		—		27,153		—		27,153
Corporate debt securities		—		46,025		—		46,025
Total assets	$	71,368	$	158,625	$	—	$	229,993

	December 31, 2018
Description	Level 1		Level 2		Level 3		Total
Money market fund	$	22,073	$	—	$	—	$	22,073
U.S. treasury securities		—		23,000		—		23,000
Commercial paper		—		45,683		—		45,683
Asset-backed securities		—		29,093		—		29,093
Corporate debt securities		—		55,077		—		55,077
Total assets	$	22,073	$	152,853	$	—	$	174,926

Summary of Carrying Amount And Estimated Fair Value of Financial Instruments

The carrying amount and estimated fair value of financial instruments not recorded at fair value at March 31, 2019 and December 31, 2018 were as follows (in thousands):

	March 31, 2019				December 31, 2018
	Carrying Amount		Estimated Fair Value		Carrying Amount		Estimated Fair Value
Long-term debt, net (1)	$	19,714	$	19,954	$	19,689	$	19,847

(1) Carrying amounts of long-term debt were net of unamortized debt discounts of $286,000 and $311,000 as of March 31, 2019 and December 31, 2018, respectively.

XML

Accrued and Other Current Liabilities (Tables)

3 Months Ended

Mar. 31, 2019

Payables and Accruals [Abstract]

Schedule of Accrued And Other Liabilities Current [Table Text Block]

Accrued and other current liabilities consist of the following (in thousands):

	March 31, 2019		December 31, 2018
Research and development related	$	8,220	$	8,466
Compensation related		1,460		2,767
Consulting and professional services		779		811
Current portion of operating lease liability		1,357		—
Other		1,049		925
	$	12,865	$	12,969

XML

Long-term Debt (Tables)

3 Months Ended

Mar. 31, 2019

Debt Disclosure [Abstract]

Schedule of Future Minimum Principal Payments Related to the Credit Facility

Future minimum principal payments, which exclude the end of term charge, related to the Credit Facility as of March 31, 2019 are as follows (in thousands):

	Amounts
Year ending December 31:
Remaining of fiscal year 2019	$	—
2020		—
2021		6,363
2022		13,637
Total minimum payments		20,000
Less: amount representing debt discount		(286	)
Present value of remaining debt payments		19,714
Less: current portion		—
Noncurrent portion	$	19,714

XML

Commitments (Tables)

3 Months Ended

Mar. 31, 2019

Commitments and Contingencies Disclosure [Abstract]

Schedule of balance Sheet Classification of Operating LeaseTable Text Block

The balance sheet classification of the Company’s operating lease liabilities was as follows (in thousands):

	March 31, 2019		December 31, 2018
Accrued and other current liabilities (1)	$	1,357	$	244
Other non-current liabilities (2)		124		143
Total lease liabilities	$	1,481	$	387

Lease, Cost [Table Text Block]

The component of lease costs, which was included in operating expenses in the Company’s Condensed Consolidated Statements of Operations, was as follows (in thousands):

	Three Months Ended March 31,
	2019		2018
Operating lease cost	$	268	$	268

Lessee, Operating Lease, Liability, Maturity [Table Text Block]

Future minimum lease payments under all noncancelable operating leases as of March 31, 2019 are as follows (in thousands):

	Operating leases
Year ending December 31:
Remaining of fiscal year 2019	$	1,080
2020		501
Total minimum payments		1,581
Less: interest		(100	)
Present value of lease liabilities	$	1,481

XML

Related-Party Transactions (Tables)

3 Months Ended

Mar. 31, 2019

Related Party Transactions [Abstract]

Schedule of Contract Assets and Liabilities and Changes in Contract Balances

The following table presents the contract assets and liabilities for all of the Company’s revenue contracts as of the following dates (in thousands):

	March 31, 2019			December 31, 2018
Contract asset:
Accounts receivable	$	167		$	2,058
Contract liability:
Deferred revenue		(126,401	)		(134,561	)

During the three months ended March 31, 2019, the Company recognized the following revenue as a result of changes in the contract asset and the contract liability balances (in thousands):

	Three Months Ended March 31, 2019
Revenue recognized in the period from:
Amount included in contract liability at the beginning of the period	$	8,160
Performance obligations satisfied (or partially satisfied) in previous periods	$	(896	)

XML

Stockholders' Equity (Tables)

3 Months Ended

Mar. 31, 2019

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of Stock Option Activity under its Stock Plans

During the three months ended March 31, 2019, the Company had the following activities under its equity incentive plans:

	Available for Grant			Shares			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value
Balance at December 31, 2018		1,708,516			10,720,200		$	8.39
Shares authorized		2,000,000			—
Granted (1)		(1,529,886	)		1,384,133			11.44
Exercised (2)		107,619			(485,012	)		5.88
Forfeited and expired (3)		584,832			(578,165	)		6.85
Outstanding at March 31, 2019		2,871,081			11,041,156		$	8.96		6.40	$	55,107,905
Vested and expected to vest, net of estimated forfeiture at March 31, 2019					10,648,497		$	8.91		6.29	$	53,745,822
Exercisable at March 31, 2019					7,200,618		$	8.56		5.00	$	39,078,897

(1) The difference between shares granted in the number of shares available for grant and outstanding options represents the RSUs and RSAs granted for the period.

(2) Shares presented as available for grant represents shares repurchased for tax withholding upon vesting of RSUs.

(3) The difference between shares forfeited and expired in the number of shares available for grant and outstanding options represents the RSUs canceled during the period.

Restricted Stock Activity

During the three months ended March 31, 2019, the activity for restricted stock is summarized as follows:

	Shares			Weighted Average Grant-Date Fair Value
Balance at December 31, 2018		467,632		$	8.47
Granted		145,753			11.23
Vested		(205,088	)		7.38
Canceled		(6,667	)		10.86
Unvested at March 31, 2019		401,630		$	9.99

XML

Description of Business - Additional Information (Detail)	3 Months Ended
	Mar. 31, 2019
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of operating segment	1

XML

Summary of Significant Accounting Policies - Summary of Accounts Receivable (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Vifor [Member]
Accounts, Notes, Loans and Financing Receivable [Line Items]
Accounts receivable	$ 167	$ 2,058

XML

Summary of Significant Accounting Policies - Potentially Dilutive Securities Excluded from Calculation of Diluted Net Income (Loss) per Share Due to Anti-Dilutive Effect (Detail) - shares	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	11,625,436	12,519,990
Options to Purchase Common Stock, Including Purchases from Contributions to ESPP [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	11,073,806	11,824,877
Unvested Restricted Stock Units (RSUs) [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	374,352	459,682
Restricted Stock Awards [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	27,278	85,431
Warrants to Purchase Common Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	150,000	150,000

XML

Summary Of Significant Accounting Policies - Schedule Of Impact Of Accompanying Consolidated Statement of Balance Sheet (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Jan. 01, 2019	Dec. 31, 2018
Assets:
Operating lease right-of-use assets	$ 1,062	$ 1,301	$ 0
Operating lease liabilities:
Accrued and other current liabilities	12,865	13,924	12,969
Other non-current liabilities	$ 445	733	$ 387
Accounting Standards Update 2016-02 [Member]
Assets:
Operating lease right-of-use assets		1,301
Accounting Standards Update 2016-02 [Member] | Accrued and other current liabilities [Member]
Operating lease liabilities:
Accrued and other current liabilities		955
Accounting Standards Update 2016-02 [Member] | Other non-current liabilities [Member]
Operating lease liabilities:
Other non-current liabilities		$ 346

XML

Cash Equivalents and Investments - Amortized Cost and Fair Value of Cash Equivalents and Investments (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	$ 229,997	$ 175,124
Gross Unrealized Gains	38	0
Gross Unrealized Losses	(42)	(198)
Available-for-sale Securities	229,993	174,926
Money Market Fund [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	71,368	22,073
Gross Unrealized Gains	0	0
Gross Unrealized Losses	0	0
Available-for-sale Securities	71,368	22,073
U.S. Treasury Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	35,798	23,013
Gross Unrealized Gains	12	0
Gross Unrealized Losses	(1)	(13)
Available-for-sale Securities	35,809	23,000
Commercial Paper [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	49,638	45,683
Gross Unrealized Gains	0	0
Gross Unrealized Losses	0	0
Available-for-sale Securities	49,638	45,683
Asset-backed Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	27,147	29,127
Gross Unrealized Gains	6	0
Gross Unrealized Losses	0	(34)
Available-for-sale Securities	27,153	29,093
Corporate Debt Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	46,046	55,228
Gross Unrealized Gains	20	0
Gross Unrealized Losses	(41)	(151)
Available-for-sale Securities	$ 46,025	$ 55,077

XML

Cash Equivalents and Investments - Amortized Cost and Fair Value of Cash Equivalents and Investments 2 (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Cash and Cash Equivalents [Abstract]
Cash equivalents	$ 75,248	$ 26,030
Short-term investments	142,777	148,896
Long-term investments	11,968	0
Total available-for-sale securities	$ 229,993	$ 174,926

XML

Cash Equivalents and Investments - Additional Information (Detail)	3 Months Ended
	Mar. 31, 2019 USD ($) Investment	Dec. 31, 2018 USD ($)
Cash and Cash Equivalents [Abstract]
Maturity period available-for-sale securities	less than two years
Significant realized gains or losses on available-for-sale securities	$ 0
Cash	$ 4,100,000	$ 2,100,000
Number of available-for-sale securities in a continuous unrealized loss position for more than 12 months | Investment	0
Number of available-for-sale securities in a continuous unrealized loss position for more than 12 months	$ 0

XML

Fair Value Measurements - Fair Value Measurements of Company's Financial Assets (Detail) - Fair Value, Measurements, Recurring [Member] - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	$ 229,993	$ 174,926
Money Market Fund [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	71,368	22,073
U.S. Treasury Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	35,809	23,000
Commercial Paper [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	49,638	45,683
Asset-backed Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	27,153	29,093
Corporate Debt Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	46,025	55,077
Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	71,368	22,073
Level 1 [Member] | Money Market Fund [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	71,368	22,073
Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	158,625	152,853
Level 2 [Member] | U.S. Treasury Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	35,809	23,000
Level 2 [Member] | Commercial Paper [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	49,638	45,683
Level 2 [Member] | Asset-backed Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	27,153	29,093
Level 2 [Member] | Corporate Debt Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total assets	$ 46,025	$ 55,077

XML

Fair Value Measurements - Additional Information (Detail)	Mar. 31, 2019 USD ($)
Fair Value Disclosures [Abstract]
Transfers from Level 1 to Level 2 financial assets	$ 0
Transfers from Level 2 to Level 1 financial assets	$ 0

XML

Fair Value Measurements - Summary of Carrying Amount and Estimated Fair Value of Financial Instruments (Detail) - Term Loan [Member] - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Carrying Amount	$ 19,714	$ 19,689
Estimated Fair Value	$ 19,954	$ 19,847

XML

Fair Value Measurements - Summary of Carrying Amount and Estimated Fair Value of Financial Instruments (Parenthetical) (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Term Loan [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Unamortized debt discounts	$ 286	$ 311

XML

Accrued and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Jan. 01, 2019	Dec. 31, 2018
Payables and Accruals [Abstract]
Research and development related	$ 8,220		$ 8,466
Compensation related	1,460		2,767
Consulting and professional services	779		811
Current portion of operating lease liability	1,357
Current portion of operating lease liability			0
Other	1,049		925
Accrued liabilities	$ 12,865	$ 13,924	$ 12,969

XML

Long-term Debt - Additional Information (Detail) - USD ($)		3 Months Ended
	Dec. 28, 2017	Mar. 31, 2019	Dec. 31, 2018
Debt Instrument [Line Items]
Line of credit facility, advance amount		$ 20,000,000
Line of credit facility, interest rate	8.05%
Line of credit facility, interest rate description		Advances under the Credit Facility bear an interest rate equal to the greater of either (i) 8.05% plus the prime rate as reported from time to time in The Wall Street Journal minus 4.75%, and (ii) 8.05%. At March 31, 2019, the interest rate on the outstanding borrowings under the Credit Facility was 8.80%. For advances made under the first and second tranches, the Company will make interest-only payments through July 1, 2021, and will then repay the principal balance and interest on the advances in equal monthly installments after the interest-only period and continuing through December 1, 2022. For advances made under the third tranche, the Company will make interest-only payments for the first 30 months, and will then repay the principal balance and interest on the advances in equal monthly installments after the interest-only period with each advance repaid 48 months after it is drawn.
Proceeds from issuance of common stock		$ 73,276,000
Term Loan [Member]
Debt Instrument [Line Items]
Line of credit facility, maximum borrowing capacity	$ 50,000,000
Line of credit facility, current borrowing capacity		$ 25,000,000
Line of credit facility, interest rate		8.80%
Line of credit facility, prepayment description	The Company may prepay advances under the Credit Facility, in whole or in part, at any time, subject to a prepayment charge equal to: (a) 1.5% of the amount so prepaid, if such prepayment occurs during the second year following the Closing Date; and (b) 1.0% of the amount so prepaid, if such prepayment occurs after the second year following the Closing Date. The Credit Facility is secured by substantially all of the Company’s assets, excluding intellectual property.
Loan commitment charge, percentage	1.00%
Borrowings outstanding		$ 19,714,000	$ 19,689,000
Discount on borrowings		$ 286,000	$ 311,000
Term Loan [Member] | Minimum [Member]
Debt Instrument [Line Items]
Aggregate proceeds to be received from equity offering	$ 20,000,000
Loan commitment charge	162,500
Hercules Capital Inc [Member] | Term Loan [Member] | Maximum [Member]
Debt Instrument [Line Items]
Proceeds from issuance of common stock	2,000,000
Tranche One [Member] | Term Loan [Member]
Debt Instrument [Line Items]
End of term charge amount for loan	900,000
Tranche Two And Tranche Three [Member] | Term Loan [Member]
Debt Instrument [Line Items]
End of term charge amount for loan	$ 300,000
End of term charge for loan	The charge is 6.25% of the aggregate amount of the advances applicable to such tranche.
End of term charge for loan, percentage	6.25%

XML

Long-term Debt - Schedule of Future Minimum Principal Payments Related to the Credit Facility (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Debt Instrument [Line Items]
Long-term debt, Non current portion	$ 19,714	$ 19,689
Term Loan [Member]
Debt Instrument [Line Items]
Remaining of fiscal year 2019	0
2020	0
2021	6,363
2022	13,637
Total minimum payments	20,000
Less: amount representing debt discount	(286)	(311)
Long-term debt, net	19,714	$ 19,689
Less: current portion	0
Long-term debt, Non current portion	$ 19,714

XML

Commitments - Schedule of Balance Sheet Classification of our Operating Lease Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Total operating lease liabilities	$ 1,357
Total operating lease liabilities		$ 0
Total operating lease liabilities	1,481
Total operating lease liabilities		387
Accrued And Other Liabilities Current [Member]
Total operating lease liabilities	1,357
Total operating lease liabilities		244
Other Noncurrent Liabilities [Member]
Total operating lease liabilities	$ 124
Total operating lease liabilities		$ 143

XML

Commitments - Schedule of Operating Expenses in the Company's Condensed Consolidated Statements of Operations (Details 1) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Operating lease cost	$ 268	$ 268

XML

Commitments - Schedule of Future Minimum Lease Payments Under all Noncancelable Operating Leases (Details 2) $ in Thousands	Mar. 31, 2019 USD ($)
Remaining of fiscal year 2019	$ 1,080
2020	501
Total minimum payments	1,581
Less: interest	(100)
Present value of lease liabilities	$ 1,481

XML

Commitments - Additional Information (Detail)	3 Months Ended
	Mar. 31, 2019 USD ($)
Operating Leased Assets [Line Items]
Discounted lease	The Company received a discounted lease rate during the first year of the agreement.
Operating Lease, Weighted Average Remaining Lease Term	1 year 1 month 6 days
Operating Lease, Weighted Average Discount Rate, Percent	11.00%
Operating Lease, Payments	$ 236,000
First Amendment August 2012 [Member]
Operating Leased Assets [Line Items]
Expiration date	2019-04
Second Amendment April 2017 [Member]
Operating Leased Assets [Line Items]
Expiration date	2020-04

XML

Related-Party Transactions - Additional Information (Detail) - USD ($)			1 Months Ended				3 Months Ended
	Jan. 01, 2018	Dec. 28, 2017	Jun. 30, 2018	Dec. 31, 2017	Feb. 28, 2017	May 31, 2016	Mar. 31, 2019	Mar. 31, 2018
Related Party Transaction [Line Items]
Non refundable upfront payments received						$ 85,000,000
Non refundable upfront payment received in equity investment, shares						3,333,333
Performance obligations satisfied (or partially satisfied) in previous periods							$ (896,000)
Upfront payments received						$ 78,000,000
Non refundable upfront payments allocated for issuance of common stock						$ 7,000,000
Issuance of common stock, per share value						$ 2.10
Collaboration and license revenue from related party							8,327,000	$ 9,546,000
Avacopan Agreement [Member]
Related Party Transaction [Line Items]
Non refundable upfront payments received						$ 85,000,000
Non refundable upfront payment received in cash						60,000,000
Non refundable upfront payment received in equity investment						$ 25,000,000
Share price of common stock in equity investment						$ 7.50
Non refundable upfront payment received in equity investment, shares						3,333,333
Performance obligations satisfied (or partially satisfied) in previous periods				$ 50,000,000
Transaction price							153,000,000
Collaboration and license revenue from related party							6,600,000	8,200,000
Avacopan Amendment [Member]
Related Party Transaction [Line Items]
Non refundable upfront payments received							20,000,000
Upfront cash commitment					$ 20,000,000
Avacopan Letter Agreement [Member]
Related Party Transaction [Line Items]
Non refundable payment for expanded rights		$ 5,000,000	$ 5,000,000
CCX140 Agreement [Member]
Related Party Transaction [Line Items]
Non refundable payment for expanded rights			$ 5,000,000				5,000,000	5,000,000
Transaction price							113,500,000
Upfront payments received	$ 50,000,000						50,000,000
Collaboration and license revenue from related party							1,700,000	$ 1,300,000
Non refundable upfront commitment				$ 50,000,000			11,500,000
CCX140 Agreement [Member] | Vifor [Member]
Related Party Transaction [Line Items]
Development funding							58,500,000
Maximum [Member] | Avacopan Agreement [Member]
Related Party Transaction [Line Items]
Potential milestone payments receivable							460,000,000
Maximum [Member] | CCX140 Agreement [Member]
Related Party Transaction [Line Items]
Potential milestone payments receivable							$ 625,000,000

XML

Related-Party Transactions - Schedule of Contract Assets and Liabilities and Changes in Contract Balances (Detail) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Accounts Receivable Net [Member]
Contract asset:
Contract asset	$ 167	$ 2,058
Deferred Revenue [Member]
Contract liability:
Contract liability	$ (126,401)	$ (134,561)

XML

Related-Party Transactions - Schedule of Contract Assets and Liabilities Changes (Detail) $ in Thousands	3 Months Ended
	Mar. 31, 2019 USD ($)
Contract with Customer Asset and Liability [Line Items]
Amount included in contract liability at the beginning of the period	$ 8,160
Performance obligations satisfied (or partially satisfied) in previous periods	$ (896)

XML

Stockholders' Equity - Stock Options - Additional Information (Detail) - USD ($)	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018	Dec. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common Stock, Par or Stated Value Per Share	$ 0.001		$ 0.001
Stock Issued During Period, Shares, New Issues	6,491,196
Proceeds from Issuance of Common Stock	$ 73,276,000
Equity Distribution Agreement [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity Distribution Agreement Aggregate Offering Price	75,000,000
Employee Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expenses	$ 38,000
Unrecognized compensation expense, weighted-average period	1 month 13 days
Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expenses	$ 19,400,000
Unrecognized compensation expense, weighted-average period	2 years 8 months 26 days
Allocated Share-based Compensation Expense	$ 2,700,000	$ 2,500,000
Restricted Stocks [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expenses	$ 2,700,000
Unrecognized compensation expense, weighted-average period	1 year 7 months 27 days

XML

Stockholders' Equity - Summary of Stock Option Activity under its Stock Plans (Detail)	3 Months Ended
	Mar. 31, 2019 USD ($) $ / shares shares
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Shares Available for Grant, Outstanding Beginning Balance	1,708,516
Available for Grant, Shares authorized	2,000,000
Shares Available for Grant, Granted	(1,529,886)
Shares Available for Grant, Exercised	107,619
Shares Available for Grant, Forfeited and expired	584,832
Shares Available for Grant, Outstanding Ending Balance	2,871,081
Shares, Options Outstanding, Beginning Balance	10,720,200
Shares, Options Outstanding, authorized	0
Shares, Options Outstanding, Granted	1,384,133
Shares, Options Outstanding, Exercised	(485,012)
Shares, Options Outstanding, Forfeited and expired	(578,165)
Shares, Options Outstanding, Ending Balance	11,041,156
Shares, Vested and expected to vest, net of estimated forfeiture at March 31, 2019	10,648,497
Shares, Exercisable at March 31, 2019	7,200,618
Weighted Average Exercise Price, Options Outstanding, Beginning Balance | $ / shares	$ 8.39
Weighted Average Exercise Price, Options Outstanding, Granted | $ / shares	11.44
Weighted Average Exercise Price, Options Outstanding, Exercised | $ / shares	5.88
Weighted Average Exercise Price, Options Outstanding, Forfeited and expired | $ / shares	6.85
Weighted Average Exercise Price, Options Outstanding, Ending Balance | $ / shares	8.96
Weighted Average Exercise Price, Vested and expected to vest, net of estimated forfeiture at March 31, 2019 | $ / shares	8.91
Weighted Average Exercise Price, Exercisable at March 31, 2019 | $ / shares	$ 8.56
Options Outstanding, Weighted Average Remaining Contractual Term	6 years 4 months 24 days
Weighted Average Remaining Contractual Term, Vested and expected to vest, net of estimated forfeiture at March 31, 2019	6 years 3 months 14 days
Weighted Average Remaining Contractual Term, Exercisable at March 31, 2019	5 years
Aggregate Intrinsic Value, Outstanding, Ending Balance | $	$ 55,107,905
Aggregate Intrinsic Value, Vested and expected to vest, net of estimated forfeiture at March 31, 2019 | $	53,745,822
Aggregate Intrinsic Value, Exercisable at March 31, 2019 | $	$ 39,078,897

XML

Stockholders' Equity - Restricted Stock Activity (Detail) - Restricted Stocks [Member]	3 Months Ended
	Mar. 31, 2019 $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares, Unvested, Beginning Balance | shares	467,632
Shares, Granted | shares	145,753
Shares, Vested | shares	(205,088)
Shares, Canceled | shares	(6,667)
Shares, Unvested, Ending Balance | shares	401,630
Weighted Average Grant-Date Fair Value, Unvested, Beginning Balance | $ / shares	$ 8.47
Weighted Average Grant-Date Fair Value, Granted | $ / shares	11.23
Weighted Average Grant-Date Fair Value, Vested | $ / shares	7.38
Weighted Average Grant-Date Fair Value, Canceled | $ / shares	10.86
Weighted Average Grant-Date Fair Value, Unvested, Ending Balance | $ / shares	$ 9.99