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Related-Party Transactions - Revenues from GSK (Detail) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2014
Jun. 30, 2013
Related Party Transaction [Line Items]        
Revenue $ 0 $ 1,886 $ 0 $ 3,813
Contract revenue [Member] | Glaxo Group Limited [Member]
       
Related Party Transaction [Line Items]        
Revenue 0 758 0 1,557
Recognition of up-front payments [Member] | Glaxo Group Limited [Member]
       
Related Party Transaction [Line Items]        
Revenue $ 0 $ 1,128 $ 0 $ 2,256