Exhibit 32.1

Certification of Chief Executive Officer and Chief Financial Officer

Pursuant to 18 U.S.C. Section 1350

As Adopted Pursuant to

Section 906 of the Sarbanes-Oxley Act of 2002

In connection with the Annual Report of Rosetta Resources Inc. (“the Company”) on Form 10-K for the period ended December 31, 2012 (“Form 10-K”), each of the undersigned officers of the Company certifies pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that to the best of such officer’s knowledge: (i) the Form 10-K fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and (ii) the information contained in the Form 10-K fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: February 26, 2013	By:	/s/ Randy L. Limbacher
		Randy L. Limbacher
		Chairman of the Board, Chief Executive Officer and President

By:	/s/ John E. Hagale
	John E. Hagale
	Executive Vice President and Chief Financial Officer