Exhibit 16.1

September 16, 2010

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549-7561

Commissioners:

We have read the first four paragraphs included in Item 4.01 of Form 8-K of GlenRose Instruments Inc. dated September 16, 2010, expected to be filed with the Securities and Exchange Commission on September 21, 2010 and are in agreement with the statements concerning our Firm in those paragraphs.

We have no basis to agree or disagree with the other statements included in such Form 8-K.

Very truly yours,

/s/ CATURANO AND COMPANY, INC.

Caturano and Company, Inc.

Boston, Massachusetts