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Stockholders' Equity - Summary of Assumptions Used to Determine Fair Value of Employee Stock Option Grants, Employee Stock Purchase Plan and Performance Options with Market Condition (Detail) - Employee Stock Option [Member]
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Risk-free interest rate, minimum 2.80% 1.07% 1.70% 0.60%
Risk-free interest rate, maximum 3.00% 1.09% 3.00% 1.09%
Expected volatility, minimum 84.70% 87.40% 84.70% 88.30%
Expected volatility, maximum 84.90% 88.29% 86.50% 104.80%
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
Minimum [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 6 years 7 days 5 years 6 months 6 years 7 days 5 years 6 months
Maximum [Member]        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term (in years) 6 years 21 days 6 years 29 days 6 years 29 days 6 years 29 days