ADAMAS PHARMACEUTICALS, INC.

1900 Powell Street, Suite 750

Emeryville, CA 94608

(510) 450-3500

November 16, 2016

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Suzanne Hayes

RE: Adamas Pharmaceuticals, Inc.
Registration Statement on Form S-3
File No. 333-214409

Ladies and Gentlemen:

Adamas Pharmaceuticals, Inc. hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 to become effective on November 21, 2016, at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable.

Very truly yours,

Adamas Pharmaceuticals, Inc.

By:     /s/ William J. Dawson         William J. Dawson

Chief Financial Officer