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Net Loss Per Shares (Details 2) - shares
shares in Thousands
9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Anti-dilutive shares excluded from the calculation of diluted net loss per share attributable to common stockholders    
Total shares excluded from net loss per share 21,454 23,395
Options to purchase common stock    
Anti-dilutive shares excluded from the calculation of diluted net loss per share attributable to common stockholders    
Total shares excluded from net loss per share 14,564 17,089
Common stock warrants    
Anti-dilutive shares excluded from the calculation of diluted net loss per share attributable to common stockholders    
Total shares excluded from net loss per share 1,459 1,459
Non-vested restricted stock unit awards    
Anti-dilutive shares excluded from the calculation of diluted net loss per share attributable to common stockholders    
Total shares excluded from net loss per share 5,431 4,847