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Leases - Additional Information (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
May 31, 2021
Nov. 30, 2022
May 31, 2022
Nov. 30, 2017
Dec. 31, 2022
Dec. 31, 2021
Apr. 30, 2021
Lessee Lease Description [Line Items]              
Initial base rent         $ 1,100 $ 1,100  
Restricted cash         1,392 329  
Lessee, Operating Lease, Option to Extend     one additional 5-year term        
Operating lease cost         $ 1,115 $ 1,056  
Watertown Lease              
Lessee Lease Description [Line Items]              
Extended lease term   2024-04   2023-04      
Lessee, Operating Lease, Existence of Option to Extend [true false]         true    
Waltham Lease              
Lessee Lease Description [Line Items]              
Debt instrument expiration date     May 01, 2023        
Other assets | Waltham Lease              
Lessee Lease Description [Line Items]              
Prepaid rent         $ 2,000    
Research and Development              
Lessee Lease Description [Line Items]              
Operating lease cost         $ 3,200    
Clinical Supply Agreement | Watertown Lease              
Lessee Lease Description [Line Items]              
Operating lease period             5 years
Operating Lease, renewal term             1 year
Office and Laboratory | Waltham Lease              
Lessee Lease Description [Line Items]              
Initial base rent $ 2,200            
Percentage of annual rent increment     3.00%        
Operating lease period     10 years 2 months        
Office and Laboratory | Maximum [Member] | Waltham Lease              
Lessee Lease Description [Line Items]              
Lease expiration date     Jul. 31, 2033        
Office furniture and fixtures | Watertown Lease              
Lessee Lease Description [Line Items]              
Lease initiation date         Apr. 30, 2020    
Lease expiration date         Jun. 30, 2024    
Certificate of Deposits | Watertown Lease              
Lessee Lease Description [Line Items]              
Restricted cash       $ 300      
Letter of Credit | Watertown Lease              
Lessee Lease Description [Line Items]              
Secured debt obligations       $ 300      
Letter of Credit | Waltham Lease              
Lessee Lease Description [Line Items]              
Secured debt obligations     $ 1,100