Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2017

Accounting Policies [Abstract]

Schedule of Restructuring Reserve by Type of Cost [Table Text Block]

The remaining accrued liability relating to our restructuring expense as of March 31, 2017 is as follows:

	Balance as of				Balance as of
	December 31,		Amortized		March 31,
Description	2016		2017		2017
Accrued sublease expense	$	109,126	$	65,217	$	43,909
Total accrued restructuring expense	$	109,126	$	65,217	$	43,909

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

Share-based compensation expense for the three months ended March 31, 2017 and 2016 was as follows:

	Three Months Ended March 31,
	2017		2016
Research and development	$	8,070	$	29,293
General and administrative		58,110		152,633
Total share-based compensation expense	$	66,180	$	181,926