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Income Taxes (Details 2) - USD ($)
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Deferred tax assets:      
Net operating loss ("NOLs") carryforwards $ 3,405,069 $ 65,635,003 $ 64,361,842
Fixed assets 149,099 139,883 166,205
Research and development credits/loss carryforwards 6,849 8,900 3,834
Share-based compensation 1,407,280 2,352,660 3,458,334
Intangible asset 1,139,746 218,300 251,524
Accrued expenses and other 817,080 253,655 434,294
Total deferred tax assets 6,925,123 68,608,401 68,676,033
Deferred tax liabilities:      
Intangibles (442,589) (380,777) (319,021)
Total deferred tax liabilities (442,589) (380,777) (319,021)
Net deferred tax assets 6,482,534 68,227,624 68,357,012
Less: Valuation allowance (6,925,123) (68,608,401) (68,676,033)
Net deferred tax liabilities $ (442,589) $ (380,777) $ (319,021)