CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Contract revenue	$ 25,175,887	$ 24,266,274	$ 20,993,605
Operating expenses:
Research and development	19,509,629	21,219,853	20,875,536
General and administrative	11,628,732	14,311,079	18,015,761
Depreciation and amortization (including $4,635,489 impairment charges in 2010)	303,916	461,073	5,655,865
Total operating expenses	31,442,277	35,992,005	44,547,162
Loss from operations	(6,266,390)	(11,725,731)	(23,553,557)
Other income (expenses):
Interest income	17,808	16,660	6,955
Interest expense	(342,561)	(54,573)	(5,936,480)
Gain on sale of assets held for sale		781,760
Realization of cumulative translation adjustment	1,227,656
Change in fair value of derivative instruments	591,039	7,144,983	(5,457,550)
Other income, net	47,862	39,328	91,355
Total other income (expenses)	1,541,804	7,928,158	(11,295,720)
Net loss before income taxes	(4,724,586)	(3,797,573)	(34,849,277)
Provision for income taxes	(195,529)
Net loss	$ (4,920,115)	$ (3,797,573)	$ (34,849,277)
Basic and diluted net loss per share	$ (0.1)	$ (0.08)	$ (1.08)
Weighted average shares used in calculation of basic and diluted net loss per share	48,323,067	47,331,763	32,309,621