Exhibit 10.45

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT		1. CONTRACT ID CODE		PAGE OF PAGES
				1		2


2. AMENDMENT/MODIFICATION NO				3. EFFECTIVE DATE	4. REQUISITION/PURCHASE REQ. NO.			5. PROJECT NO. (If applicable)
01				See 16C	VR092

ISSUED BY			CODE	2668-30052	7. ADMINISTERED BY (If other than Item 6)			CODE
National Institutes of Health Contract Management Branch, NIAID 6700-B Rockledge Drive Room 2230, MSC 7612 Bethesda, MD 20892-7612					DMID-VR

8. NAME AND ADDRESS OF CONTRACTOR (No., street, country, State and ZIP Code)						x	9A. AMENDMENT OF SOLICITATION NO.

Avacia Limited PO Box 42, Hexagon House Blackley Manchester, M9 8ZS England							9B. DATED (SEE ITEM 11)
						x	10A. MODIFICATION OF CONTRACT/ORDER NO.
							NO1-AI-30052
							10B. DATED (SEE ITEM 13)
CODE				FACILITY CODE			September 30, 2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers o is extended, o is not extended. Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.
12. ACCOUNTING AND APPROPRIATION DATA (If required) DOC#300N1AI30052A EIN 1-900216013-A1 CAN 3-8460924 SOCC# 25.55 []*
13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.
	A.	THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.
	B.	THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).
	C.	THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
x	D.	OTHER (Specify type of modification and authority) Unilateral - Article B.2.f.
E. IMPORTANT: Contractor x is not, o is required to sign this document and return copies to the issuing office.
14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)
PURPOSE: The purpose of this modification is to add an increment of funds.

TOTAL FUNDS ALLOTTED

TOTAL ESTIMATED COST

AMOUNT

Cost

Fixed Fee

CPFF

Cost

Fixed Fee

CPFF

Total Prior to this MOD:

[***]

MOD #01:

[***]

TOTAL

[***]


COMPLETION DATE: [***]
FUNDED THROUGH: [***]

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.
15A. NAME AND TITLE OF SIGNER (Type or print)		16A. NAME AND TILE OF CONTRACTING OFFICER (Type or print)
		[***]
		[***]

15B. CONTRACTOR/OFFEROR	15C. DATE SIGNED	16B. UNITED STATES OF AMERICA			16C. DATE SIGNED
					[***]
		BY	[***]
(Signature of person authorized to sign)			(Signature of Contracting Officer)

NSN 7540-01-152-8070	OMB No. 0990-0115			STANDARD FORM 30 (REV. 10-83)

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1. CONTRACT ID CODE

PAGE OF PAGES

2. AMENDMENT/MODIFICATION NO

3. EFFECTIVE DATE

4. REQUISITION/PURC

5. PROJECT NO. (if applicable)

See Block 16 C

N/A

6. ISSUED BY

CODE

7. ADMINISTERED BY (if other than Item 6)

CODE

National Institutes of Health

Contract Management Branch, NIAID

6700-B Rockledge Drive

Room 2230, MSC 7612

Bethesda, MD 20892-7612

DMID - VRCB

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State, and ZIP Code)

9A. AMENDMENT OF SOLICITATION NO.

Avecia, Limited

9B. DATED (SEE ITEM 11)

P.O. Box 42 Hexagon House

Blackleyh

10A. MODIFICATION OF CONTRACT/ ORDER NO.

Manchester, M9 8ZS

N01-AI-30052

England

10B. DATED (SEE ITEM 13)

September 29, 2003

CODE

FACILITY CODE

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers o is extended, o is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you desire to change an offer already submitted, such change maybe made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

N/A

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

{PRIVATE}	A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A

	B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b)

x	C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO THE AUTHORITY OF: FAR 1.602-1

	D. OTHER (Specify type of modifications and authority)
E. IMPORTANT: Contractor o is not, o is required to sign this document and return 2 copies to the issuing office.
14. DESCRIPTION OF AMENDMENT MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible) PURPOSE: To modify ARTICLE G.1- PROJECT OFFICER and ARTICLE B.4 - ADVANCE UNDERSTANDINGS. Total Estimated Cost Plus Fixed Fee - [*] (Unchanged) Total Funds Allotted: [] (Unchanged) Completion Date: [] (Unchanged) Funded Through: [*] (Unchanged)

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print) [***]				16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print) [*] [*]

15B. CONTRACTOR/OFFEROR [***]			15C. DATE SIGNED 3August2004	16B. UNITED STATES OF AMERICA			16C. DATE SIGNED 8/6/04
				BY	[***]
(Signature of person authorized to sign)				(Signature of Contracting Officer)

NSN 7540-01-152-8070		OMB No. 9009-0115				STANDARD FORM 30 (REV. 10-83) FAR (48 CFR) 53.243

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT	1.	CONTRACT ID CODE	PAGE OF PAGES
		N/A	1	3

2. AMENDMENT/MODIFICATION NO. 04		3. EFFECTIVE DATE see block 16C, below		4. REQUISITION/PURCHASE REQ. NO. VRCB146			5. PROJECT NO. (if applicable)

6. ISSUED BY	CODE			ADMINISTERED BY (if other than Item 6) VR				CODE

National Institutes of Health National Institute of Allergy and Infectious Diseases DEA, Contract Management Program Room 3214, MSC 7612 6700-B Rockledge Drive Bethesda, MD 20892-7912
8. NAME AND ADDRESS OF CONTRACTOR (No. Street, County, State and ZIP Code)					o	9A. AMENDMENT OF SOLICITATION NO.
Avecia Ltd P.O. Box 42, Hexagon House						9B. DATED (SEE ITEM 11)
Blackley Manchester, M9 8ZS						10A. MODIFICATION OF CONTRACT/ORDER NO. N01-AI-30052
England					x	10B. DATED (SEE ITEM 13)
CODE			FACILITY CODE			September 29, 2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended and set forth in Item 14. The hour and date specified for receipt of Offers o is extended, o is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and the specified in the solicitation or as amended, by one of the following methods:

(a) By completing Items 8 and 15, and returning (1) copy of the amendment, (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATA SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required

EIN #1-900216013-A1 CAN #4-8460924 - [***] SOC #25.55 [***]

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,
IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

o	A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (*Specify authority*) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.
	B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).
	C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
x	D. OTHER (Specify type of modification and authority) Article B.2.f.
E. IMPORTANT: Contractor x is not, o is required to sign this document and return copies to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.) PURPOSE: To provide incremental funding and to update Section H. articles.

	TOTAL FUNDS ALLOTTED
	Estimated Cost	Fixed Fee	Total Allotted Amount
Prior to this mod:	[***]	[***]	[***]
This modification #4:	[***]	[***]	[***]
Total:	[***]	[***]	[***]
Total Funds Allotted: [***]
TOTAL Contract Amount: [***]
Funded Through: [***]
Contract Completion Date: [***]

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)			16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print) [***]
15B. CONTRACTOR/OFFEROR		15C. DATE SIGNED	16B. UNITED STATES OF AMERICA [***]		16C. DATE SIGNED [***]
			BY
(Signature of person authorized to sign)			(Signature of Contracting Officer)

NSN 7540-01-152-8070 PREVIOUS EDITION UNUSABLE	30-105 Computer Generated			STANDARD FORM 30 (REV. 10-83) Prescribed by GSA FAR (40 CFR) 53.243

SPECIAL PROVISIONS	CONTRACT No. N01-AI-30052	Page 2 of 3 Pages
	Modification No. 4

ARTICLE B.2. ESTIMATED COST AND FIXED FEE - paragraphs d., e. and g. are hereby modified to read as follows:

d. Total funds currently available for payment and allotted to this contract are hereby increased by [***] from [***] to [***]; of which [***] represents an increase to the estimated cost from [***] to [***] and of which [***] represents an increase to the fixed fee from [***] to [***]. For further provisions on funding, see the LIMITATION OF FUNDS Clause referenced in Part II, ARTICLE 1.2., Authorized Substitution of Clauses.

e. It is estimated that the amount currently allotted will cover performance of the contract through [***].

g. Future increments to be allotted to this contract are estimated as follows:

PERIOD		ESTIMATED COST		FIXED FEE		TOTAL AMOUNT
[***]		[***]		[***]		[***]

ARTICLE H.6. CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH - paragraph b. is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 108-199, Title V-General Provisions, Section 510	2004	10/01/2003 -09/30/2004

ARTICLE H.7. NEEDLE EXCHANGE - paragraph b. is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 108-199, Title V-General Provisions, Section 505	2004	10/01/2003 09/30/2004

ARTICLE H.12. SALARY RATE LIMITATION LEGISLATION PROVISIONS, paragraphs b and c are hereby modified to add the following:

b.	Public Law. No.	Fiscal Year	Dollar Amount of Salary Limitation

	P.L. 108-199, Title II - General Provisions, Section 204	2004	Executive Level I

c. Direct salaries which will be paid with FY-04 funds are limited to the Executive Level 1 rate which was in effect on the date(s) the expense was incurred.

*For contract expenditures using FY-04 funds, the Executive Level I rate for the period 10/1/03 - 12/31/03 is $171,900. Effective 1/1/04, for contract expenditures using FY-04 funds, the Executive Level 1 rate was increased to $175,700 and will remain at that level until such time as it is determined to raise the Executive Schedule annual rates. See the web site listed below for Executive Schedule rates of pay.

LINK to EXECUTIVE LEVEL SALARIES: http://www.opm.gov/oca/PAYRATES/index.htm
(Click on “Executive Schedule” for the current Fiscal Year’s salary rate or scroll down to the “General Schedule Salary Tables from Previous Years” to locate the Executive Level salary rates from previous years.)

NOTE:

All prior Public Laws and related Executive Levels incorporated in the Basic Award and all previous Modifications shall remain in effect for the applicable fiscal year and related funds.

SPECIAL PROVISIONS	CONTRACT No. N01-AI-30052	Page 3 of 3 Pages
	Modification No. 4

ARTICLE H.14. PRESS RELEASES, paragraph b., is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 108-199, Title V - General Provisions, Section 507	2004	10/01/2003-09/30/2004

ARTICLE H.16. ANTI-LOBBYING, paragraph c. is hereby modified to add the following:

a.		Pursuant to Public Law(s) cited in paragraph c., below, contract funds shall not be used, other than for normal and recognized executive-legislative relationships, for publicity or propaganda purposes, for the preparation, distribution, or use of any kit, pamphlet, booklet, publication, radio, television, or video presentation designed to support or defeat legislation pending before the Congress or any State legislature, except in presentation to the Congress or any State legislature itself.

b.		Contract funds shall not be used to pay salary or expenses of the contractor or any agent acting for the contractor, related to any activity designed to influence legislation or appropriations pending before the Congress or any State legislature.

All other terms and conditions of the contract remain unchanged.

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1. CONTRACT ID CODE

PAGE OF PAGES

2. AMENDMENT /MODIFICATION NO
Mod #06

3. EFFECTIVE DATE
See Block 16 C

4. REQUISITION/PURC
N/A

5. PROJECT NO. (If applicable)
N/A

6. ISSUED BY

CODE

7. ADMINISTERED BY (If other than Item 6)

CODE

National Institutes of Health

Contract Management Program, NIAID

6700-B Rockledge Drive

Room 3214, MSC 7612

Bethesda, MD 20892-7612

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and Zip Code)

9A. AMENDMENT OF SOLICITATION NO.

Avecia Limited

9.B. DATED (SEE ITEM 11)

P.O. Box 42, Hexagon House

Blackley, Manchester, M9 8ZS, UK

10A. MODIFICATION PF CONTRACT/ORDER NO.

N01-AI-30052

10B. DATED (SEE ITEM 13)

CODE

FACILITY CODE

September 29, 2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

“ The above numbered solicitation is amended as set forth in item 14. The hour and date specified for receipt of offers” is extended. “ is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing items 8 and 15, and returning copies of the amendment: (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

x	A.	THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.
x	FAR 43.202

	B.	THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(B).

	C.	THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF: FAR 1.602-1 AND 52.243-2, Changes - Cost Reimbursement, Alternate V

	D.	OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor o is not, x is required to sign this document and return 3 copies to the issuing office

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)

PURPOSE: To issue a Change Order to the Statement of Work and revise the milestone payment schedule in Article B.4.

TOTAL AMOUNT FUNDED: [***]
TOTAL ESTIMATED COST: [***]
FUNDED THROUGH: [***]
CONTRACT EXPIRATION DATE: [***]

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changes, remains unchanges and in full force and effect

15A. NAME AND TITLE OF SIGNER (Type or Print)					16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)
[***]

15B. CONTRACTOR/OFFEROR				15C. DATE SIGNED	16B. UNITED STATES OF AMERICA			16C. DATE SIGNED
[***]				27JUL05	[*] [*]			[***]
[***]					BY	[***]
(Signature of person authorized to sign)					(Signature of contracting Officer)

NSN 7540-01-152-8070			OMB No. 0990-0115				STANDARD FORM 30 (REV. 10-83) Far (48 CFR) 53.243

SPECIAL PROVISIONS	CONTRACT No. HHSN26620030052C	Page 2 of pages 8
	Modifications No. 6

ARTICLE B.4. ADVANCE UNDERSTANDINGS - Paragraph h., item 17 is deleted, and items 4-8, and 10-16 are hereby revised as follows:

h. Contract Milestones

The Contractor shall complete all work in accordance with the Statement of Work and the contract milestones set forth below. The distribution of the fixed fee shall be paid in milestone based installments and payment of this fee shall be determined by the Project Officer’s written certification that the milestone has been satisfactorily performed and that the technical requirements have been met regarding the completion of the following milestones: If the Contractor meets the milestones earlier than the dates set forth below, then the fee will be paid at the earlier date after completion of the milestone.

	MILESTONES FOR AVECIA	ESTIMATED COST	FIXED FEE	TOTAL CPFF
4	[***]	[***]	[***]	[***]

	a) [***]		a) [***]
			b) [***]
	b) [***]		c) [***]

	c) [***]

5	[***]	[***]	[***]	[***]

	Fee shall be paid in two installments for this milestone based on the completion of the following items:		a) [***]
			b) [***]

	a) [***]

	b) [***]

6	[***]	[***]	[***]	[***]

	Fee shall be paid in three installments for this milestone based on the completion of the following items:		a) [***]

	a) [***]

SPECIAL PROVISIONS	CONTRACT No. HHSN26620030052C	Page 3 of pages 8
	Modification No. 6

	b) [***]		b) [***]
	c) [***]		c) [***]

7	[***]	[***]	[***]	[***]

8	[***]	[***]	[***]	[***]

	Fee shall be paid in six installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]
	b) [***]		b) [***]
	c) [***]		c) [***]
	d) [***]		d) [***]
	e) [***]		e) [***]
	f) [***]		f) [***]

SPECIAL PROVISIONS	CONTRACT No. HHSN26620030052C	Page 4 of pages 8
	Modification No. 6

10	[***]	[***]	[***]	[***]

	Fee shall be paid in three installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]
	b) [***]		b) [***]
	c) [***]		c) [***]

11	[***]	[***]	[***]	[***]
	Fee shall be paid in three installments for this milestone based on the completion of the following items:
	a) [***]		a) [***]
	b) [***]		b) [***]
	c) [***]		c) [***]

SPECIAL PROVISIONS	CONTRACT No. HHSN26620030052C	Page 5 of pages 8
	Modification No. 6

12	[***]	[***]	[***]	[***]

	Fee shall be paid in two installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]
	b) [***]		b) [***]

13	[***]	[***]	[***]	[***]

	Fee shall be paid in six installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]
	b) [***]		b) [***]
	c) [***]		c) [***]
	d) [***]		d) [***]
	e) [***]		e) [***]
	f) [***]		f) [***]

14	[***]	[***]	[***]	[***]

	Fee shall be paid in three yearly installments for this milestone based on the completion of the following

SPECIAL PROVISIONS	CONTRACT No. HHSN26620030052C	Page 6 of pages 8
	Modification No. 6

	items:		a) [***]
			b) [***]
	a) [***]		c) [***]
	b) [***]
	c) [***]

15	[***]	[***]	[***]	[***]
			a) [***]
	Fee shall be paid in three equal installments (one each		b) [***]
	year) on provision of [***]		c) [***]

	a) [***]
	b) [***]
	c) [***]

16	[***]	[***]	[***]	[***]
			a) [***]
	Fee shall be paid in three installments (one each		b) [***]
	year) upon completion of [***]		c) [***]

	a) [***]
	b) [***]
	c) [***]

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT				1. CONTRACT ID CODE N/A				PAGE OF PAGES
								1		3

2. AMENDMENT/MODIFICATION NO. 07		3. EFFECTIVE DATE [See block 16C, below]	4. REQUISITION/PURCHASE REQ. NO. DMID 2 017			5. PROJECT NO. (If applicable) N/A

ISSUED BY	CODE		7. ADMINISTERED BY (If other than Item 6)				CODE		N/A

National Institutes of Health National Institute of Allergy and Infectious Diseases DEA, Contract Management Branch Room 3214, MSC 7612 6700-B Rockledge Drive Bethesda, MD 20892-7612			MID2-RCB


8. NAME AND ADDRESS OF CONTRACTOR (No., street, country, State and ZIP Code)				x	9A. AMENDMENT OF SOLICITATION NO.

Avacia Limited P.O. Box 42, Hexagon House Blackley, Manchester, M9 8ZS, UK					9B. DATED (SEE ITEM 11)

		x	10A. MODIFICATION OF CONTRACT/ORDER NO.
			NO1-AI-30052

			10B. DATED (SEE ITEM 13)
CODE	FACILITY CODE		09/30/2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers o is extended, o is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes references to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

DOC#300N1AI30052A EIN 1-900216013-A1 CAN 3-8460924 SOCC# 25.55 [***]

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	A.	THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

	B.	THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

	C.	THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

x	D.	OTHER (Specify type of modification and authority) P.L. 1.602-1; Limitation of Funds Clause and P.L. 108-447
E. IMPORTANT: Contractor x is not, o is required to sign this document and return copies to the issuing office.
14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)
PURPOSE: Incremental Funding.

Total Funds Currently Allotted

Total Estimated Cost

Cost

Fixed Fee

CPFF

Cost

Fixed Fee

CPFF

Total Prior to this Mod:

[***]

Mod #01:

[***]

Revised TOTAL

[***]

COMPLETION DATE: [***]

FUNDED THROUGH: [***]

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)		16A. NAME AND TILE OF CONTRACTING OFFICER (Type or print) [*] [*]

15B. CONTRACTOR/OFFEROR	15C. DATE SIGNED	16B. UNITED STATES OF AMERICA			16C. DATE SIGNED
					[***]
		BY	[***]
(Signature of person authorized to sign)		(Signature of Contracting Officer)

NSN 7540-01-152-8070 PREVIOUS EDITION UNUSABLE	30-105 Computer Generated			STANDARD FORM 30 (REV. 10-83)STANDARD FORM 30 (REV. 10-83 Prescribed by GSA FAR (48 CFR) 53.243

CONTRACT No. N01-AI-30052	SPECIAL PROVISIONS	Page 2 of 3
Modification No. 07

ARTICLE B.2. ESTIMATED COST AND FIXED FEE, paragraphs d. and e., are hereby modified to read as follows and paragraph g. is deleted in its entirety:

d. Total funds currently available for payment and allotted to this contract are hereby increased by [***] from [***] to [***]; of which [***] represents an increase to the estimated cost from [***] to [***]; and of which [***] represents an increase to the fixed fee from [***] to [***]. For further provisions on funding, see the LIMITATION OF COST Clause referenced in Part II, ARTICLE 1.1., General Clauses for a Cost-Reimbursement Research and Development Contract.

e. It is estimated that the amount currently allotted will cover performance of the contract through [***]. By virtue of this action, this contract is hereby fully funded.

ARTICLE H.6. CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH, paragraph b. is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 108-447, Title V General Provisions, Section 509	2005	10/01/04-09/30/05

ARTICLE H.7. NEEDLE EXCHANGE, paragraph b, is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 108-447, Title V - General Provisions, Section 505	2005	10/01/04-09/30/05

ARTICLE H.12. SALARY RATE LIMITATION LEGISLATION PROVISIONS, paragraphs b. and c. are hereby modified to add the following:

b.	Public Law No.	Fiscal Year	Dollar Amount of Salary Limitation*

	P.L. 108-447. Title II, General Provisions, Section 204	2005	Executive Level I

c. Direct salaries are limited to the Executive Level I rate which was in effect on the date(s) the expense was incurred.

*For the period 10/1/04-12/31/04, the Executive Level I rate is $175,700. Effective 1/1/05, the Executive Level I rate increased to $180,100 and will remain at that rate until it is revised. See the web site listed below for Executive Schedule rates of pay.

LINK to EXECUTIVE LEVEL SALARIES: http://www.opm.gove/oca/05tables/html/ex.asp (For previous years, go to: http://www.opm.gove/oca/05tables/index.asp and click on the year to locate the Executive Level salary rates.)

NOTE:

All prior Public Laws and related Executive Levels incorporated in the Basic Award and all previous Modifications shall remain in effect for the applicable fiscal year and related funds.

HHS-556

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT					1. CONTRACT ID CODE N/A					PAGE OF PAGES
										1	4
2. AMENDMENT/MODIFICATION NO		3.	EFFECTIVE DATE	4. REQUISITION/PURCHASE REQ. NO.			5. PROJECT NO. (If applicable)
08			[See block 16C, below]				N/A

ISSUED BY	CODE			7. ADMINISTERED BY (If other than Item 6)				CODE	N/A
National Institutes of Health National Institute of Allergy and Infectious Diseases DEA, Contract Management Branch Room 3214, MSC 7612 6700-B Rockledge Drive Bethesda, MD 20892-7612				MID-RCB-B

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)					x	9A. AMENDMENT OF SOLICITATION NO.

Avacia Limited PO Box 42, Hexagon House Blackley, Manchester, M9 8ZS, UK						9B. DATED (SEE ITEM 11)
					x	10A. MODIFICATION OF CONTRACT/ORDER NO.
						N01-AI-30052
						10B. DATED (SEE ITEM 13)
CODE		FACILITY CODE				09/30/2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers o is extended, ois not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes references to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

EIN 1-900216013-A1 SOCC# 25.55 CAN 6-846701 [***]

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	A.	THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.
	B.	THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).
	C.	THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
x	D.	OTHER (Specify type of modification and authority) P.L. 1.602-1; Limitation of Cost Clause and P.L. 109-149
E. IMPORTANT: Contractor o is not, x is required to sign this document and return 2 copies to the issuing office.
14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)
PURPOSE: To increase the Total Estimated Cost of the contract and obligate funds in the amount of the increase.

Total Funds Currently Allotted

Total Estimated Cost

Cost

Fee

Total

Cost

Fee

Total

Total Prior to this Mod:

[***]

This Mod #

[***]

Revised Total

[***]

COMPLETION DATE: [***]
FUNDED THROUGH: [***]

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.
15A. NAME AND TITLE OF SIGNER (Type or print)		16A. NAME AND TILE OF CONTRACTING OFFICER (Type or print)
[***]


15B. CONTRACTOR/OFFEROR	15C. DATE SIGNED	16B. UNITED STATES OF AMERICA			16C. DATE SIGNED
[***]	30 August 2006	[***]			[***]
		BY
(Signature of person authorized to sign)			(Signature of Contracting Officer)

NSN 7540-01-152-8070 PREVIOUS EDITION UNUSABLE	30-105 Computer Generated			STANDARD FORM 30 (REV. 10-83 Prescribed by GSA FAR (48 CFR) 53.243

CONTRACT No: N01-AI-30052	SPECIAL PROVISIONS	Page 2 of 4
Modification No: 08

ARTICLE B.2. ESTIMATED COST AND FIXED FEE, paragraphs a., c., d., and e., are hereby modified to read as follows:

a.		The estimated cost of this contract is increased by [*] from [] to [**].

c.		The Government’s obligation, represented by the sum of the estimated cost plus fixed fee, is increased [*] from [] to [**].

d.		Total funds currently available for payment and allotted to this contract are hereby increased by [*] from [] to []; of which [] represents an increase to the estimated cost from [] to [] and of which [] represents and increase to the fixed fee remaining unchanged at [*] For further provisions on funding, see the LIMITATION OF COST Clause referenced in Part II, ARTICLE 1.1., General Clauses for a Cost-Reimbursement Research and Development Contract.

e.		It is estimated that the amount currently allotted will cover performance through contract completion.

ARTICLE B.3. ADVANCE UNDERSTANDINGS, paragraphs h., is hereby modified to revise the submilestone estimated cost, fixed fee and total cost plus fixed fee detail as follows (all other aspect and descriptions of the milestone chart remains inchanged):

Milestone	Submilestone	Estimated Cost	Fixed Fee	Total CPFF
[***]		[***]	[***]	[***]

[***]		[***]	[***]	[***]

[***]		[***]	[***]	[***]

[***]		[***]	[***]	[***]
	[***]		[***]
	[***]		[***]
	[***]		[***]

[***]		[***]	[***]	[***]
	[***]		[***]
	[***]		[***]

[***]		[***]	[***]	[***]
	[***]		[***]
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[***]		[***]	[***]	[***]

[***]		[***]	[***]	[***]
	[***]		[***]
	[***]		[***]

HHS-556

CONTRACT No: N01-AI-30052	SPECIAL PROVISIONS	Page 3 of pages 4
Modification No: 08

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[***]		[***]	[***]	[***]

HHS-556

CONTRACT No: N01-AI-30052	SPECIAL PROVISIONS	Page 4 of pages 4
Modification No: 08

ARTICLE H.6. CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH, paragraph b. is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 109-149, Title V - General Provisions, Section 509	2006	10/01/05-09/30/06

ARTICLE H.7. NEEDLE EXCHANGE, paragraph b. is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 109-149, Title V - General Provisions, Section 505	2006	10/01/05-09/30/06

ARTICLE H.12. SALARY RATE LIMITATION LEGISLATION PROVISIONS, paragraphs b. and c. are hereby modified to add the following:

b.	Public Law No.	Fiscal Year	Dollar Amount of Salary Limitation*

	P.L. 109-149	2006	Executive Level I

Payment of direct salaries is limited to the Executive Level I* rate which was in effect on the date(s) the expense was incurred.

*	For the period 10/1/05 - 12/31/05, the Executive Level I rate is $180,100. Effective January 1, 2006, the Executive Level I rate increased to $183,500 and will remain at that rate until it is revised. See the web site listed below for the Executive Schedule rates of pay:

FOR FY06 EXECUTIVE LEVEL SALARIES EFFECTIVE JANUARY 1, 2006:

http://www.opm.gove/oca/06tables/html/ex.asp

(Note: This site shows the FY-06 rates. For previous years, click on “salaries and wages” and then scroll down to the bottom of the page and click on the year to locate the desired Executive Level salary rates.)

NOTE: All prior Public Laws and related Executive Levels incorporated in the Basic Award and all previous Modifications shall remain in effect for the applicable fiscal year and related funds.

ARTICLE H.14. PRESS RELEASES, paragraph b., is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 109-149, Title V - General Provisions, Section 506	2006	10/01/05-09/30/06

ARTICLE H.16. ANTI-LOBBYING, paragraph c., is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 109-149, Title V - General Provisions, Section 503a	2006	10/01/05-09/30/06
	P.L. 109-149, Title V - General Provisions, Section 503b	2006	10/01/05-09/30/06

HHS-556

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT				1. CONTRACT ID CODE N/A					PAGE OF PAGES
									1	2
2. AMENDMENT/MODIFICATION NO		3. EFFECTIVE DATE	4. REQUISITION/PURCHASE REQ. NO.			5. PROJECT NO. (If applicable)
09		[See block 16C, below]				N/A

ISSUED BY	CODE		7. ADMINISTERED BY (If other than Item 6)				CODE	N/A
National Institutes of Health, HHS National Institute of Allergy and Infectious Diseases DEA, Contract Management Branch 6700-B Rockledge Drive Room 3214, MSC 7612 Bethesda, MD 20892-7612			MID RCB-B

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)				x	9A. AMENDMENT OF SOLICITATION NO.

Avacia Limited PO Box 42, Hexagon House Blackley, Manchester, M9 8ZS, UK					9B. DATED (SEE ITEM 11)
				x	10A. MODIFICATION OF CONTRACT/ORDER NO.
					N01-AI-30052
					10B. DATED (SEE ITEM 13)
CODE		FACILITY CODE			09/30/2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers o is extended, o is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes references to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

EIN 1-900216013-A1; SOCC 25-55

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS, IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	A.	THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.
	B.	THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).
	C.	THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
x	D.	OTHER (Specify type of modification and authority) P.L. 1.602-1; Limitation of Cost Clause and P.L. 109-149
E. IMPORTANT: Contractor o is not, x is required to sign this document and return 2 copies to the issuing office.
14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)
PURPOSE: Modify Invoice Payment Procedures under ARTICLE G.3.
COMPLETION DATE: [***]					FUNDED THROUGH: [***]

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.
15A. NAME AND TITLE OF SIGNER (Type or print)				16A. NAME AND TILE OF CONTRACTING OFFICER (Type or print)
[***]				[***]
[***]				[***]

15B. CONTRACTOR/OFFEROR			15C. DATE SIGNED	16B. UNITED STATES OF AMERICA				16C. DATE SIGNED
[***]			14JUN07	[***]				[***]

				BY
(Signature of person authorized to sign)						(Signature of Contracting Officer)

NSN 7540-01-152-8070 PREVIOUS EDITION UNUSABLE			30-105 Computer Generated				STANDARD FORM 30 (REV. 10-83 Prescribed by GSA FAR (48 CFR) 53.243

CONTRACT No. N01-AI-30052	SPECIAL PROVISIONS	Page 2 of 2
Modification No. 9

ARTICLE G.3. INVOICE SUBMISSION/CONTRACT FINANCING REQUEST AND CONTRACT FINANCIAL REPORT - is hereby modified to read as follows:

a.	Invoice/Financing Request Instructions and Contract Financial Reporting for NIH Cost-Reimbursement Type Contracts NIH(RC)-4 are attached and made part of this contract. The Contractor shall follow the attached instructions and submission procedures specified below to meet the requirements of a “proper invoice” pursuant to FAR Subpart 32.9, Prompt Payment.

	(1)	Payment requests shall be submitted as follows:

		On original to follow designated billing office:

			National Institutes of Health
			Office of Financial Management
			Commercial Accounts
			2115 East Jefferson Street, Room 4b-432, MSC 8500
			Bethesda, MD 20892-8500

		(2)	In addition to the requirements specified in FAR Subpart 32.9 for a proper invoice, the Contractor shall include the following information on all payment request:

			(a)	Name of the Office of Acquisitions. The Office of Acquisitions for this contract is NIAID.

			(b)	Central Point of Distribution. For the purpose of this contract, the Central Point of Distribution is NIAID OA Invoices.

			(c)	Vendor Identification Number. This is the 7 digit number that appears after the Contractors name in Block 7 of Standard Form 26. (Note: This only applies to new contracts awarded on/after June 4, 2007, and any existing contract modified to include the number.)

			(d)	DUNS number or DUNS+4 that identifies the Contractor’s name and address exactly as stated on the face page of the contract.

			(e)	Identification of whether payment is to be made using a two-way or three-way match. This contract requires a two-way match.

b.	Inquiries regarding payment shall be directed to the designated billing office, (301) 496-6088.

SECTION J - Attachment 2, Invoice/Financing Request Instructions and Contract Financial Reporting for NIH Cost-Reimbursement Type Contracts NIH(RC)-4 is hereby replaced with the following updated attachment.

HHS-556

INVOICE/FINANCING REQUEST AND CONTRACT FINANCIAL REPORTING
INSTRUCTIONS FOR NIH COST-REIMBURSEMENT CONTRACTS, NIH(RC)-4

Format: Payment requests shall be submitted on the Contractor’s self-generated form in the manner and format prescribed herein and as illustrated in the Sample Invoice/Financing Request. Standard Form 1034, Public Voucher for Purchases and Services Other Than Personal, may be used in lieu of the Contractor’s self generated form provided it contains all of the information shown on the Sample Invoice/ Financing Request. DO NOT include a cover letter with the payment request.

Number of Copies: Payment requests shall be submitted in the quantity specified in the Invoice Submission Instructions in Section G of the Contract Schedule.

Frequency: Payment requests shall not be submitted more frequently than once every two weeks in accordance with the Allowable Cost and Payment Clause incorporated into this contract. Small business concerns may submit invoices/financing requests more frequently than every two weeks when authorized by the Contracting Officer.

Cost Incurrence Period: Costs incurred must be within the contract performance period or covered by precontract cost provisions.

Billing of Costs Incurred: If billed costs include (1) costs of a prior billing period, but not previously billed, or (2) costs incurred during the contract period and claimed after the contract period has expired, the Contractor shall site the amount(s) and month(s) in which it incurred such costs.

Contractor’s Fiscal Year: Payment requests shall be prepared in such a manner that Government can identify costs claimed with the Contractor’s fiscal year.

Currency: All NIH Contracts are expressed in United States dollars. When the Government pays in a currency other than United States dollars, billings shall be expressed, and payment by the Government shall be made, in that other currency at amounts coincident with actual costs incurred. Currency fluctuations may not be a basis of gain or loss to the Contractor. Notwithstanding the above, the total of all invoices paid under this contract may not exceed the United States dollars authorized.

Costs Requiring Prior Approval: Costs requiring the Contracting Officer’s approval, which are not set forth in an Advance Understanding in the contract, shall be identified and reference the Contracting Officer’s Authorization (COA) Number. In addition, the Contractor shall show any cost set forth in Advance Understanding as a separate line item on the payment request.

Invoice/Financing Request Identification: Each payment request shall be identified as either:

(a) Interim Invoice/Contract Financing Request: These are interim payment requests submitted during the contract performance period.

(b) Completion Invoice: The completion invoice shall be submitted promptly upon completion of the work, but no later than one year from the contract completion date, or within 120 days after settlement of the final indirect cost rates covering the year in which the contract is physically complete (whichever date is later). The Contractor shall submit the completion invoice when all costs have been assigned to the contract and it completes all performance provisions.

(c) Final Invoice: A final invoice may be required after the amounts owed have been settled between the Government and the Contractor (e.g., resolution of all suspensions and audit exceptions).

Preparation and Itemization of the Invoice/Financing Request: The Contractor shall furnish the information set forth in the instructions below. The instructions are keyed to the entries on the Sample Invoice/Financing request.

(a) Designated Billing Office Name and Address: Enter the designated billing office name and address, as identified in the Invoice Submission Instructions in Section G of the Contract Schedule.

(b) Contractor’s Name, Address, Point of contact, VIN, and DUNS or DUNS+4 Number: Show the Contractor’s name and address exactly as they appear in the contract, along with the name, title,

NIH(RC)-4		ATTACHMENT 2
Rev. 05/2007		Page 1

phone number, and e-mail address of the person to notify in the event of an improper invoice or, in the case of payment by method other than Electronic Funds Transfer, to whom payment is to be sent. Provide the Contractor’s Vendor Identification Number (VIN), and Data Universal Numbering System (DUNS) number or DUNS+4. The DUNS number must identify the Contractor’s name and address exactly as stated on the face page of the contract. When an approved assignment has been made by the Contractor, or a different payee has been designated, provide the same information for the payee as is required for the Contractor (i.e., name, address, point of contract, VIN, and DUNS).

(d) Date Invoice/Financing Request Prepared: Insert the date the payment request is prepared.

(e) Contract Number and Order Number (if applicable): Insert the contract number and order number (if applicable).

(f) Effective Date: Insert the effective date of the contract or if billing under an order, the effective date of the order.

(g) Total Estimated Cost of Contract/Order: Insert the total estimated cost of the contract, exclusive of fixed-fee. If billing under an order, insert the total estimated cost of the order, exclusive of fixed-fee. For incrementally funded contracts/orders, enter the amount currently obligated and available for payment.

(h) Total Fixed-Fee: Insert the total fixed-fee (where applicable). For incrementally funded contracts/orders, enter the amount currently obligated and available for payment.

(i) Two-Way/Three-Way Match: Identify whether payment is to be made using a two-way or three-way match. To determine required payment method, refer to the Invoice Submission Instructions in Section G of the Contract Schedule.

(j) Office of Acquisitions: Insert the name of the office of Acquisitions, as identified in the Invoice Submission Instruction in Section G of the Contract Schedule.

(k) Central Point of Distribution: Insert the Central Point of Distribution, as identified in the Invoice Submission Instructions in Section G of the Contract Schedule.

(l) Billing Period: Insert the beginning and ending dates (month, day, and year) of the period in which costs were incurred and for which reimbursement is claimed.

(m) Amount Billed - Current Period: Insert the amount claimed for the current billing period by major cost element, including any adjustments and fixed-fee. If the Contract Schedule contains separately priced line items, identify the contract line item(s) on the payment request and include a separate breakdown (by major cost element) for each line item.

(n) Amount Billed - Cumulative: Insert the cumulative amounts claimed by major cost element, including any adjustments and fixed-fee. If the Contract Schedule contains separately priced line items, identify the contract line item(s) on the payment request and include a separate breakdown (by major cost element) for each line item.

(o) Direct Costs: Insert the major cost elements. For each element, consider the application of the paragraph entitled “Costs Requiring Prior Approval” on page 1 of these instructions.

(1) Direct Labor: Include salaries and wages paid (or accrued) for direct performance of the contract.

For Level of Effort contracts only, the Contractor shall provide the following information on a separate sheet of paper attached to the payment request:

· hours or percentage of effort and cost by labor category (as specified in the Level of Effort Article in Section F of the contract) for the current billing period, and

NIH(RC)-4		ATTACHMENT 2
Rev. 05/2007		Page 2

· hours or percentage of effort and cost by labor category from contract inception through the current billing period. (NOTE: The Contracting Officer may require the Contractor to provide additional breakdown for direct labor, such as position title, employee name, and salary or hourly rate)

(2) Fringe Benefits: List any fringe benefits applicable to direct labor and billed as a direct cost. Do not include in this category fringe benefits that are included in indirect costs.

(3) Accountable Personal Property: Include permanent research equipment and general purpose equipment having a unit acquisition cost of $1,000 or more, with a life expectancy of more than two years, and sensitive property regardless of costs (see the HHS contractor’s Guide for Control of Government Property). Show permanent research equipment separate from general purpose equipment.

On a separate sheet of paper attached to the payment request, list each item for which reimbursement is request. An asterisk (*) shall precede the item if the equipment is below the $1,000 approval level. Include reference to the following (as applicable):

· item number for the specific piece of equipment listed in the Property Schedule, and

· COA number, if the equipment is not covered by the Property Schedule.

The Contracting Officer may require the Contractor to provide further itemization of property having specific limitations set forth in the contract.

(4) Materials and Supplies: Include equipment with unit costs of less than $1,000 or an expected service life of two years or less, and consumable material and supplies regardless of amount.

(5) Premium Pay: List remuneration in excess of the basic hourly rate.

(6) Consultant Fee: List fees paid to consultants. Identify consultant by name or category as set for in the contract or COA, as well as the effort (i.e., number of hours, days, etc.) and rate billed.

(7) Travel: Include domestic and foreign travel. Foreign travel is travel outside of Canada, the United States and its territories and possessions, foreign travel means travel outside that country. Foreign travel must be billed separately from domestic travel.

(8) Subcontract Costs: List subcontractor(s) by name and amount billed.

(9) Other: List all other direct costs in total unless exceeding $1,000 in amount. If over $1,000, list cost elements and dollar amounts separately. If the contract contains restrictions on any cost element, that cost element must be listed separately.

(p) Cost of Money (COM): Cite the COM factor and base in effect during the time the cost was incurred and for which reimbursement is claimed.

(q) Indirect Costs: Identify the indirect cost base (IDC), indirect cost rate, and amount billed for each indirect cost category.

(r) Fixed-Fee: Cite the formula or method for computation or fixed-fee, if applicable. The fixed-fee must be claimed as provided for by the contract.

(s) Total Amounts Claimed: insert the total amounts claimed for the current and cumulative periods.

(t) Adjustments: include amounts conceded by the Contractor, outstanding suspensions, and/or disapprovals subject to appeal.

NIH(RC)-4		ATTACHMENT 2
Rev. 05/2007		Page 3

(u) Grand Totals

(v) Certification of Salary Rate Limitation: If required by the contract (see Invoice Submission Instructions in Section G of the Contract Schedule), the Contractor shall include the following certification at the bottom of the payment request:

“I herby certify that the salaries billed in this payment request are in compliance with the Salary Rate Limitation Provisions in Section H of the contract.”

The Contracting Officer may require the Contractor to submit detailed support for costs claimed on one or more interim payment requests.

FINANCIAL REPORTING INSTRUCTIONS:

These instructions are keyed to the Columns on the sample invoice/financing request.

Column A - Expenditure Category: Enter the expenditure categories required by the contract.

Column B - Cumulative Percentage of Effort/Hrs. - Negotiated: Enter the percentage of effort or number of hours agreed to for each employee or labor category listed in Column A.

Column C - Cumulative Percentage of Effort/Hrs. - Actual: Enter the percentage of effort or number of hours worked by each employee or labor category listed in Column A.

Column D - Amount Billed - Current: Enter amounts billed during the current period.

Column E - Amount Billed - Cumulative: Enter the cumulative amounts to date.

Column F - Cost at Completion: Enter data only when the Contractor estimates that a particular expenditure category will vary from the amount negotiated. Realistic estimates are essential.

Column G - Contract Amount: Enter the costs agreed to for all expenditure categories listed in Column A.

Column H - Variance (Over or Under): Show the difference between the estimated costs at completion (Column F) and negotiated costs (Column G) when entries have been made in Column F. This column need not be filled in when Column F is blank. When a line item varies by plus or minus 10 percent, i.e., the percentage arrived at by dividing Column F by Column G, an explanation of the variance should be submitted. In the case of an overrun (net negative variance), this submission shall not be deemed as notice under the Limitation of Cost (Funds) Clause of the contract.

Modifications: Any modification i the amount negotiated for an item since the preceding report should be listed in the appropriate cost category.

Expenditures Not Negotiated: An expenditure for an item for which no amount was negotiated (e.g., at the discretion of the Contractor in performance of its contract) should be listed in the appropriate cost category and all columns filled in, except for G. Column H will of course show a 100 percent variance and will be explained along with those identified under H above.

NIH(RC)-4		ATTACHMENT 2
Rev. 05/2007		Page 4

SAMPLE INVOICE/FINANCING REQUEST AND CONTRACT FINANCIAL REPORT

(a) Designated Billing Office Name and Address:

National Institutes of Health

Office of Financial Management

Commercial Accounts

2115 East Jefferson Street, Room 4B432, MSC 8500

Bethesda, MD 20692-8500

(b) Contractor’s Name, Address, Point of Contact, VIN, and DUNS or DUNS+4 Number:

ABC CORPORATION

100 Main Street

Anywhere, USA Zip Code

Name, Title, Phone Number, and E-mail Address of person to notify in the event of an improper invoice or, in the case of payment by method other than Electronic Funds Transfer, to whom payment is to be sent

VIN:

DUNS or DUNS+4

(d) Date Invoice Prepared:

(e) Contract No. and Order No. (if applicable):

(f) Effective Date:

(g) Total Estimated Cost of Contract/Order:

(h) Total Fixed-Fee (if applicable):

(i) o Two-Way Match o Three-Way Match

(j) Office of Acquisitions:

(k) Central Point of Distribution:

(l) This invoice /financing request represents reimbursable costs for the period to

Cumulative Percentage of

Amount Billed

Effort/Hrs

(n)

Cost at

Contract

Expenditure Category*

Negotiated

Actual

(m) Current

Cumulative

Completion

Amount

Variance

(o) Direct Costs:

(1) Direct Labor

(2) Fringe Benefits

(3) Accountable Property

(4) Materials and Supplies

(5) Premium Pay

(6) Consultant Fees

(7) Travel

(8) Subcontracts

(9) Other

Total Direct Costs

(p) Cost of Money

(q) Indirect Costs

(r) Fixed Fee

(s) adjustments

(t) adjustments

(u) Grand Totals

I certify that all payments are for appropriate purposes and in accordance with the contract


	(Name of Official)		(Title)

* Attach details as specified in the contract

NIH(RC)-4		ATTACHMENT 2
Rev. 05/2007		Page 5

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1. CONTRACT ID CODE

N/A

PAGE OF PAGES

2. AMENDMENT/MODIFICATION NO	3. EFFECTIVE DATE	4. REQUISITION/PURCHASE REQ. NO.	5. PROJECT NO. (If applicable)
10	[see block 16C, below]	DMIO 2 017	N/A

ISSUED BY	CODE	7. ADMINISTERED BY (If other than Item 6)	CODE	N/A

National Institutes of Health National Institute of Allergy and Infectious Diseases DEA, Contract Management Branch Room 3214 MSC 7612 6700-B Rockledge Drive Bethesda, MD 20892-7612		MID2-RCB

8. NAME AND ADDRESS OF CONTRACTOR (No., Street, county, State and ZIP Code)		o	9A. AMENDMENT OF SOLICITATION NO.
			9A. AMENDMENT OF SOLICITATION NO.
Avecia Limited PO Box 42, Hexagon House Blackley, Manchester, M9 8ZS, UK			9B. DATED (SEE ITEM 11)
		x	10A. MODIFICATION OF CONTRACT/ORDER NO.
			NO1-AI-30052

			10B. DATED (SEE ITEM 13)
CODE	FACILITY CODE		09/30/2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

oThe above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers ois extended, ois not extended

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

(a) By completing Items 8 and 15, and returning one (1) copy of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes references to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

EIN 1-900216013 - A1 SOCC 25.55

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,
IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
P.L. 1.602-1

OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor o is not, x is required to sign this document and return 2 copies to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)

PURPOSE: To increase the Total Estimated Cost and Fixed Fee; clarify Part B Statement and Work and the corresponding milestones; and to extend the contract completion date.

TOTAL FUNDS ALLOTTED

TOTAL ESTIMATED COST

AMOUNT

Cost

Fee

Total

Cost

Fee

Total

Prior to this Mod:

[***]

This Mod #01:

[***]

Revised TOTAL

[***]

FUNDED THROUGH DATE:

[***]

COMPLETION DATE:

[***]

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)

[***]

16A. NAME AND TILE OF CONTRACTING OFFICER (Type or print)

[***]

NSN 7540-01-152-8070

PREVIOUS EDITION UNUSABLE

30-105

Computer Generated

STANDARD FORM 30 (REV. 10-83)

Prescribed by GSA

FAR (48 CFR 53 243)

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1. CONTRACT ID CODE

N/A

PAGE OF PAGES

2. AMENDMENT/MODIFICATION NO	3. EFFECTIVE DATE	4. REQUISITION/PURCHASE REQ. NO.	5. PROJECT NO. (If applicable)
10	[see block 16C, below]	DMIO 2 017	N/A

ISSUED BY	CODE	7. ADMINISTERED BY (If other than Item 6)	CODE	N/A

National Institutes of Health National Institute of Allergy and Infectious Diseases DEA, Contract Management Branch Room 3214, MSC 7812 6700-B Rockledge Drive Bethesda, MD 20892-7612		MID2-RCB

8. NAME AND ADDRESS OF CONTRACTOR (No., Street, County, State and ZIP Code)		o	9A. AMENDMENT OF SOLICITATION NO.
			9A. AMENDMENT OF SOLICITATION NO.
Avecia Limited PO Box 42, Hexagon House Blackley, Manchester, M9 8ZS, UK			9B. DATED (SEE ITEM 11)
		x	10A. MODIFICATION OF CONTRACT/ORDER NO.
			NO1-AI-30052

			10B. DATED (SEE ITEM 13)
CODE	FACILITY CODE		09/30/2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers ois extended, ois not extended

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

12. ACCOUNTING AND APPROPRIATION DATA (If required)

EIN 1-900216013-A1 SOCC 25.55

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,
IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
P.L. 1.602-1

	D.	OTHER (Specify type of modification and authority)
	E.	IMPORTANT: Contractor o is not, x is required to sign this document and return 2 copies to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)

PURPOSE: Fixed fee; clarify font B statement of Work and the corresponding miles tones; and to extend the contract completion date.

TOTAL FUNDS ALLOTTED

TOTAL ESTIMATED COST

AMOUNT

Cost

Fee

Total

Cost

Fee

Total

Prior to this MOD:

[***]

This Mod #:

[***]

Revised TOTAL

[***]

FUNDED THROUGH DATE:

August 31, 2009 (Unchanged)

COMPLETION DATE:

August 31, 2013 (Unchanged)

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)

[***]

16A. NAME AND TILE OF CONTRACTING OFFICER (Type or print)

[***]

NSN 7540-01-152-8070

PREVIOUS EDITION UNUSABLE

30-105

Computer Generated

STANDARD FORM 30 (REV. 10-83)

Prescribed by GSA

FAR (48 CFR) 53.243

Contract No: N01-AI-30052
Modification No: 10

SPECIAL PROVISIONS

Page 2 of 8

ARTICLE B.2. ESTIMATED COST AND FIXED FEE, - paragraphs a., b., and c. are hereby modified to read as follows:

a. The estimated cost of this contract is increased by [***] from [***] to [***].

b. The fixed fee for this contract is increased by [***] from [***] to [***].

c. The Government’s obligation, represented by the sum of the estimated cost plus fixed fee, is increased by [***] from [***] to [***].

ARTICLE B.4. ADVANCE UNDERSTANDINGS, paragraph h., is hereby modified to revise the submilestone estimated cost, fixed fee, total cost plus fixed fee, and clarification of the work to be completed per milestone; detail as follows (all other aspects and descriptions of the milestone chart remain unchanged):

	MILESTONES FOR AVECIA	ESTIMATED COST	FIXED FEE	TOTAL CPFF
4	[***]	[***]	[***]	[***]

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

5	[***]	[***]	[***]	[***]

	Fee shall be paid in two installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]

	b) [***]		b) [***]

Contract No: N01-AI-30052
Modification No: 10

SPECIAL PROVISIONS

Page 3 of 8

6	[***]	[***]	[***]	[***]

	Fee shall be paid in three installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

7	[***]	[***]	[***]	[***]

8	[***]	[***]	[***]	[***]

	Fee shall be paid in six installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

	d) [***]		d) [***]

	e) [***]		e) [***]

	f) [***]		f) [***]

Contract No: N01-AI-30052
Modification No: 10

SPECIAL PROVISIONS

Page 4 of 8

10	[***]	[***]	[***]	[***]

	Fee shall be paid in three installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

	d) [***]		d) [***]

	e) [***]		e) [***]

	f) [***]		f) [***]

	g) [***]		g) [***]

	h) [***]		h) [***]

Contract No: N01-AI-30052
Modification No: 10

SPECIAL PROVISIONS

Page 5 of 8

11	[***]	[***]	[***]	[***]

	Fee shall be paid in five installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

	d) [***]		d) [***]

	e) [***]		e) [***]

Contract No: N01-AI-30052
Modification No: 10

SPECIAL PROVISIONS

Page 6 of 8

12	[***]	[***]	[***]	[***]

	Fee shall be paid in two installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]

	b) [***]		b) [***]

13	[***]	[***]	[***]	[***]

	Fee shall be paid in six installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

	d) [***]		d) [***]

	e) [***]		e) [***]

	f) [***]		f) [***]

14	[***]	[***]	[***]	[***]

	Fee shall be paid in three yearly installments for this milestone based on the completion of the following items:

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

Contract No: N01-AI-30052
Modification No: 10

SPECIAL PROVISIONS

Page 7 of 8

15	[***]	[***]	[***]	[***]

	Fee shall be paid in three equal installments (one each year) on provision of

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

16	[***]	[***]	[***]	[***]

	Fee shall be paid in three installments (one each year) upon completion

	a) [***]		a) [***]

	b) [***]		b) [***]

	c) [***]		c) [***]

	d) [***]		d) [***]

	e) [***]		e) [***]

	f) [***]		f) [***]

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1. CONTRACT ID CODE

N/A

PAGE OF PAGES

2. AMENDMENT/MODIFICATION NO	3. EFFECTIVE DATE	4. REQUISITION/PURCHASE REQ. NO.	5. PROJECT NO. (If applicable)
11	[see block 16C, below]	182712	N/A

ISSUED BY	CODE	7. ADMINISTERED BY (If other than Item 6)	CODE	N/A

National Institutes of Health National Institute of Allergy and Infectious Diseases DEA, Contract Management Branch Room 3214, MSC 7612 6700-B Rockledge Drive Bethesda, MD 20892-7612		MID2-RCB
		VIN: 1109979

8. NAME AND ADDRESS OF CONTRACTOR (No., street, country, State and ZIP Code)		o	9A. AMENDMENT OF SOLICITATION NO.
			9A. AMENDMENT OF SOLICITATION NO.
Avecia Limited PO Box 42, Hexagon House Blackley, Manchester, M9 8ZS, UK			9B. DATED (SEE ITEM 11)
		x	10A. MODIFICATION OF CONTRACT/ORDER NO.
			N01-AI-30052

			10B. DATED (SEE ITEM 13)
CODE	FACILITY CODE		09/30/2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers ois extended, ois not extended

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

12. ACCOUNTING AND APPROPRIATION DATA (If required)

EIN 1-900216013-A1 SOCC 25.55 CAN: 8475593 [***]

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,
IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

OTHER (Specify type of modification and authority)

FAR 1.602-1 and FAR 52.232-11, Limitation of Funds

IMPORTANT: Contractor x is not, o is required to sign this document and return 2 copies to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)

PURPOSE: The purpose of this modification is to add an increment of funds.

TOTAL FUNDS ALLOTTED

TOTAL ESTIMATED COST

AMOUNT

Cost

Fee

Total

Cost

Fee

Total

Total Prior to this MOD:

[***]

MOD #01:

[***]

TOTAL

[***]

FUNDED THROUGH DATE:	[***]	COMPLETION DATE:	[***]

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)

16A. NAME AND TILE OF CONTRACTING OFFICER (Type or print)

[***]

NSN 7540-01-152-8070

PREVIOUS EDITION UNUSABLE

30-105

Computer Generated

STANDARD FORM 30 (REV. 10-83)

Prescribed by GSA

FAR (48 CFR) 53 243

Contract No: N01-A1-30052

Modification No: 11

SPECIAL PROVISIONS

Page 2 of 3

ARTICLE B.2. ESTIMATED COST AND FIXED FEE, - paragraphs d. and e., are hereby modified to read as follows:

d.	Total funds currently available for payment and allotted to this contract are hereby increased by [*] from [] to []; of which [] represents an increase to the estimated cost from [] to []; and of which [] represents an increase to the fixed fee from [] to [**]. For further provisions on funding, see the LIMITATION OF FUNDS Clause referenced in Part II, ARTICLE I.1., General Clauses for a Cost-Reimbursement Research and Development Contract.

e.	It is estimated that the amount currently allotted will cover performance through January 31, 2011.

ARTICLE H.6. CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH, paragraph b. is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 110-005, Section 509 *	2007	10/01/06 - 09/30/07

*Public Law 110-005, Revised Continuing Appropriations Resolution, 2007, extends the legislative provisions provided in the FY 2006 Appropriations Act (Public Law 109-149) through the end of FY 2007.

ARTICLE H.7. NEEDLE EXCHANGE, paragraph b. is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 110-005, Section 505 *	2007	10/01/06 - 09/30/07

*Public Law 110-005, Revised Continuing Appropriations Resolution, 2007, extends the legislative provisions provided in the FY 2006 Appropriations Act (Public Law 109-149) through the end of FY 2007.

ARTICLE H.12. SALARY RATE LIMITATION LEGISLATION PROVISIONS, paragraphs b. and c. are hereby modified to add the following:

b.	Public Law and No.	Fiscal Year	Dollar Amount of Salary Limitation*

	P.L. 110-005, Section 204 *	2007	Executive Level I

	*Public Law 110-005, Revised Continuing Appropriations Resolution, 2007, extends the legislative provisions provided in the FY 2006 Appropriations Act (Public Law 109-149) through the end of FY 2007. Therefore, the provision that restricts the amount of direct salary to Executive Level I of the Federal Executive Pay Scale continues through FY 2007. The Executive Level I annual salary rate was $183,500 for the period January 1 through December 31, 2006. Effective January 1, 2007, the Executive Level I salary rate increased to $186,600.

c.	Payment of direct salaries is limited to the Executive I* rate which was in effect on the date(s) the expense was incurred.

HHS-556

Contract No: N01-A1-30052

Modification No: 11

SPECIAL PROVISIONS

Page 3 of 3

FOR FY -07 EXECUTIVE LEVEL SALARIES EFFECTIVE JANUARY 1, 2007:

http://www.opm.gov/oca/07tables/html/ex.asp

(Note: This site shows the FY-07 rates. For previous years, click on “salaries and wages” and then scroll down to the bottom of the pages and click on the year to locate the desired Executive Level salary rates.)

NOTE:

All prior Public Laws and related Executive Levels incorporated in the Basic Award and all previous Modifications shall remain in effect for the applicable fiscal year and related funds.

ARTICLE H.14. PRESS RELEASES, paragraph b., is hereby modified to add the following:

b.	Public Law and Section No.	Fiscal Year	Period Covered

	P.L. 110-005, Section 506 *	2007	10/01/06 - 09/30/07

*Public Law 110-005, Revised Continuing Appropriations Resolution, 2007, extends the legislative provisions provided in the FY 2006 Appropriations Act (Public Law 109-149) through the end of FY 2007.

ARTICLE H.16. ANTI-LOBBYING, paragraph c., is hereby modified to add the following:

c.	Public Law and Section No.	Fiscal Year	Period Covered

	for a., above: P.L. 110-005, Section 503(a)*	2007	10/01/06 - 9/30/07
	for b., above: P.L. 110-005, Section 503(b)*	2007	10/01/06 - 9/30/07

*Public Law 110-005, Revised Continuing Appropriations Resolution, 2007, extends the legislative provisions provided in the FY 2006 Appropriations Act (Public Law 109-149) through the end of FY 2007.

HHS-556

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

1 CONTRACT ID CODE

PAGE OF PAGES

N/A

2 AMENDMENT/MODIFICATION NO

3 EFFECTIVE DATE

4 REQUISITION/PURCHASE REQ. NO.

5 PROJECT NO (If applicable)

[see block 16C, below]

N/A

6 ISSUED BY

CODE

7 ADMINISTERED BY (If other than Item 6)

CODE

N/A

National Institutes of Health
National Institute of Allergy and Infectious Diseases
DEA, Contract Management Branch
Room 3214, MSC 7612

5700-B Rockledge Drive
Bethesda, MD 20892-7612

MID - RCB-B

8. NAME AND ADDRESS OF CONTRACTOR (No Street County State and ZIP Code)

9A. AMENDMENT OF SOLICITATION NO

PharmAthene UK, Limited VIN: 1148448
Johnson Matthey Building
PO Box 88, Haverton Hill Road
Billingham TS23 1XN

9B. DATED (SEE ITEM 11)

10A. MODIFICATION OF CONTRACT/ORDER NO

NO1-AI-30052

10B. DATED (SEE ITEM 13)

CODE

FACILITY CODE

09/30/2003

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers o is extended, o is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

(a) By completing Items 8 and 15, and returning one (1) copy of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATA SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified

12. ACCOUNTING AND APPROPRIATION DATA (If required)

SOCC 25.55

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,
IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

(C)

A. THIS CHANGE ORDER IS ISSUED PURSUANT TO (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO IN ITEM 10A.

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
FAR 42,12 and FAR 1.502-1

	D. OTHER (Specify type of modification and authority)
E. IMPORTANT: Contractor o is not, x is required to sign this document and return 2 copies to the issuing office.
14 DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)
PURPOSE: To recognize the Contractor’s successor in Interest from Avecia Biologica Limited to Pharmothene UK, Limited, to revise ARTICLE B.4. ADVANCED UNDERSTANDINGS and ARTICLE G.1. PROJECT OFFICER.

Total Funds Currently Allotted

Total Estimated Cost

Cost

Fee

Total

Cost

Fee

Total

Prior to this Mod:

[***]

117,736,200

[***]

118,036,200

This Mod #

[***]

-0-

[***]

-0-

Revised Total

[***]

117,736,200

[***]

118,036,200


FUNDED THROUGH DATE: January 31, 2001 (Unchanged)				COMPLETION DATE: August 31, 2013 (Unchanged)

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)			16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)
Chris Camut, VP, CFO/UK Board of Directors			Karen M. Gamble
			Contracting Officer, DEA, NIAID, HIH

15B. CONTRACTOR/OFFEROR		15C. DATE SIGNED	16B. UNITED STATES OF AMERICA				16C. DATE SIGNED
		12/4/08					12/4/08
/s/ Chris Camut			BY		/s/ Karen Gamble
(Signature of person authorized to sign)					(Signature of Contracting Officer)

NSN 7540-01-152-8070 PREVIOUS EDITION UNUSABLE	30-105 Computer Generated					STANDARD FORM 30 (REV. 10-83) Prescribed by GRA FAR (48 CPR) 53.243

List of Affected Contracts

Contract number N01-AI-25492

Contract between Avecia Biologics Limited and the National Institute of Allergy and Infectious Diseases (NIAID), part of the US National Institutes of Health (NIH), for “Development and Testing of Vaccines Against Anthrax.”

This contract is substantially complete. As at 15th January 2008, the total contract amount was $10,155,120 and there was an [***] which is under discussion between Avecia Biologics Limited and NIAID.

Contracting Office:		National Institutes of Health
		Office of Acquisitions, NIAID
		Room 3214
		6700-B Rockledge Dr., MSC 7612
		Bethesda, Maryland 20892-7612

Contract number N01-AI-30052

Contract between Avecia Biologics Limited and the National Institute of Allergy and Infectious Diseases (NIAID), part of the US National Institutes of Health (NIH), for “Production and Testing of Anthrax Recombinant Protective Antigen.”

As at 15th April 2008, the total contract value was $118,036,200 and the total estimated costs remaining to complete were [***].

Contracting Office:		National Institutes of Health
		Office of Acquisitions, NIAID
		Room 3214
		6700-B Rockledge Dr., MSC 7612
		Bethesda, Maryland 20892-7612

Contract number HHSN266200400034C, N01-AI-40034

As at 15th April 2008, the total contract value was $50,701,714 and the total estimated costs remaining to complete were [***].

Contracting Office:		National Institutes of Health
		Office of Acquisitions, NIAID
		Room 3214
		6700-B Rockledge Dr., MSC 7612
		Bethesda, Maryland 20892-7612

Special Provisions	Contract No. N01-AI-30052	Page 2 of 2
	Modification No. 01

{PRIVATE} Special Provisions	Contract No. N01-AI-30052	Page 2 of 3
	Modification No. 03

DELETE	REPLACE WITH

Contract Management Branch	Contract Management Program
CMB, NIAID, NIH	CMP, NIAID, NIH
Room 2230, MSC 7612	Room 3214, MSC 7612
6700-B Rockledge Drive	6700-B Rockledge Drive
Bethesda, MD 20892-7612	Bethesda, MD 20892-7612

{PRIVATE} Special Provisions	Contract No. N01-AI-30052	Page 3 of 3
	Modification No. 03

d.	Total funds currently available for payment and allotted to this contract are increased by [*] from [] to [] of which [] represents the estimated costs, and of which [**] represents the fixed fee. These funds cover the start dates for Milestones 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, and 17. For further provisions on funding see the LIMITATION OF FUNDS clause referenced in Part II, Article 1.2. Authorized Substitutions of Clauses.

e.	It is estimated that the amount currently allotted will cover performance of the contract through [***].

g.	Future increments to be allotted to this contract are estimated as follows:

	These funds cover continuation of Milestones 7, 9, 10, 11, 12, 13, and 17.

	No other terms and conditions are changed by this modification.

SPECIAL PROVISIONS	CONTRACT No. HHSN26620030052C	Page 7 of pages 8
	Modification No. 6

SPECIAL PROVISIONS	CONTRACT No. HHSN26620030052C	Page 8 of pages 8
	Modification No. 6

		Division of Microbiology and Infectious Diseases
		National Institute of Allergy and Infectious Diseases
		Room 6111, 6610 Rockledge Drive
		Bethesda, MD 20892-6603
		Ph: 301-496-1884
[***]
Avecia Biotechnology
PO Box 2, Belasis Avenue
Billingham
TS23 1 YN United Kingdom

June 12, 2006

Re: []*

Dear Dr. Duchars,

[***]

[***]
1. Not to further modify the CDC approved modified code 2. To use the routines exclusively for government purposes within the scope of the DMID contract. 3. To contact the CDC for a commercial use license in the event the routines are required for any private or commercial purposes.

If Avecia Biotechnology agrees with the terms of this LoA please have an authorized signatory sign below.

[***]


[***]
[***]
Division of Microbiology and Infectious Diseases

Accepted and Agreed on behalf of Avecia Biotechnology:

[***]
Avecia Biotechnology	6610 Rockledge Dr
Belasis Avenue	Room 5119
Billingham, Cleveland	Bethesda, MD 20892-6604
TS23 1YN, United Kingdom	Ph 301-451-4806
	Fax 301-496-8030
	swinram@niaid.nih.gov

RE: Letter of Agreement - NIAID’s Clinical Trials using Avecia’s rPA Vaccine Candidate

Dear Matthew,

[***]

[***]

NIAID agrees that Avecia may have the following involvement in the DMID sponsored clinical trial:

[***]


Sincerely,	Authorized Representative for Avecia Biotechnology:

	[***] 30th June 2004
[***]	Signature & Date
[***]
[***]	Name:	[***]
[***]
July 2, 2007	Title:	[***]

Signed	/s/ Duncan McLellan

Name and Title	Duncan McLellan - Director and Chief Financial Officer

Signed	/s/ David P. Wright

Name and Title	David P. Wright - CEO

Public Law and Section No.

Fiscal Year

Period Covered

for a. above:
P.L. 108-199, Title V - General Provisions, Section 503a

10/01/2003 - 09/30/2004

for b. above:
P.L. 108-199, Title V - General Provisions, Section 503b

10/01/2003 - 09/30/2004