-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KwT+TT7OWm88I8E9THSWz4mMxIBwqD36qE1tCN9G+2czxN6WNCk8MA3HXe73VirU
 t10zs+n7OVkYLxHma0f0+w==

<SEC-DOCUMENT>9999999995-09-000956.txt : 20090416
<SEC-HEADER>9999999995-09-000956.hdr.sgml : 20090416
<ACCEPTANCE-DATETIME>20090416001512
ACCESSION NUMBER:		9999999995-09-000956
CONFORMED SUBMISSION TYPE:	EFFECT
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20090415
DATE AS OF CHANGE:		20090416
EFFECTIVENESS DATE:		20090415

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Advanced Life Sciences Holdings, Inc.
		CENTRAL INDEX KEY:			0001322734
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				300296543
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		EFFECT
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-158494
		FILM NUMBER:		09752567

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(630) 739-6744

	MAIL ADDRESS:	
		STREET 1:		1440 DAVEY ROAD
		CITY:			WOODRIDGE
		STATE:			IL
		ZIP:			60517
</SEC-HEADER>
<DOCUMENT>
<TYPE>EFFECT
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0101</schemaVersion>

    <submissionType>EFFECT</submissionType>

    <act>33</act>

    <testOrLive>LIVE</testOrLive>

    <effectiveData>
        <finalEffectivenessDispDate>2009-04-15</finalEffectivenessDispDate>
        <finalEffectivenessDispTime>13:00:00</finalEffectivenessDispTime>
        <form>S-3</form>
        <filer>
            <cik>0001322734</cik>
            <entityName>Advanced Life Sciences Holdings, Inc.</entityName>
            <fileNumber>333-158494</fileNumber>
        </filer>
    </effectiveData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----