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Note 15 - Right-of-use Assets - Right-of-use Assets (Details) - USD ($)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Apr. 01, 2019
Jan. 01, 2019
Operating lease right-of-use assets (Note 15) $ 134,914   $ 76,557
Capitalization of operating lease right-of-use assets 125,474      
Amortization of operating lease right-of use assets (72,416)    
Facility in Vancouver, Canada [Member]        
Operating lease right-of-use assets (Note 15)     $ 125,474  
Capitalization of operating lease right-of-use assets 125,474      
Operating Lease, License Agreement [Member]        
Capitalization of operating lease right-of-use assets $ 5,299