Exhibit 32.1

Certification Pursuant to 18 U.S.C. Section 1350,

as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Matthew D. Thompson, Acting Chief Operating Officer and Chief Financial Officer (Principal Executive Officer) of  American CareSource Holdings, Inc. (the “Company”), and Laura L. Little, Vice President of Finance (Principal Financial Officer and Principal Accounting Officer) of the Company, each certify pursuant to section 906 of the Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that:

1. The Annual Report on Form 10-K of the Company for the year ended December 31, 2013, as filed with the Securities and Exchange Commission (the "Report"), fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 as amended; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated:	February 28, 2014	By: /s/ Matthew D. Thompson
		Matthew D. Thompson
		Acting Chief Operating Officer and Chief Financial Officer (Principal Executive Officer)
Dated:	February 28, 2014	By: /s/ Laura L. Little
		Laura L. Little
		Vice President of Finance (Principal Financial Officer and Principal Accounting Officer)

This certification is made solely for the purpose of 18 U.S.C Section 1350, subject to the knowledge standard contained therein, and not for any other purpose.

A signed original of this written statement required by Section 906 has been provided to American CareSource Holdings, Inc. and will be retained by American CareSource Holdings, Inc. and furnished to the Securities and Exchange Commission upon request.