EXHIBIT 1

AGREEMENT

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need to be filed with respect to the ownership by each of the undersigned of shares of Common Stock of Tobira Therapeutics, Inc.

Dated November 3, 2016	Frazier Healthcare V, L.P.
	By FHM V, L.P., its General Partner
	By FHM V, L.L.C., its General Partner
	By:	/s/ Steve R. Bailey
		Steve R. Bailey, Chief Financial Officer
Dated November 3, 2016	FHM V, L.P.
	By: FHM V, L.L.C., its General Partner
	By:	/s/ Steve R. Bailey
		Steve R. Bailey, Chief Financial Officer
Dated November 3, 2016	FHM V, L.L.C.
	By:	/s/ Steve R. Bailey
		Steve R. Bailey, Chief Financial Officer
Dated November 3, 2016	*
	Alan Frazier
Dated November 3, 2016	*
	Nader Naini
Dated November 3, 2016	*
	Patrick Heron
Dated November 3, 2016	*
	James Topper
Dated November 3, 2016	*
	Nathan Every
	*By:	/s/ Steve R. Bailey
		Steve R. Bailey, as Attorney-in-Fact

This Schedule 13D was executed by Steve R. Bailey on behalf of the individuals listed above pursuant to a Power of Attorney a copy of which is attached as Exhibit 2.