The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108   44,652,296 2,414,943 SH   SOLE   2,414,943 0 0
ACELYRIN INC COM 00445A100   11,577,465 1,715,180 SH   SOLE   1,715,180 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   706,592 569,832 SH   SOLE   569,832 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   737,271 225,465 SH   SOLE   225,465 0 0
ALIGN TECHNOLOGY INC COM 016255101   16,102,512 49,105 SH   SOLE   49,105 0 0
ALKERMES PLC SHS G01767105   13,415,675 495,592 SH   SOLE   495,592 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   27,314,379 182,766 SH   SOLE   182,766 0 0
AMICUS THERAPEUTICS INC COM 03152W109   110,073,522 9,344,102 SH   SOLE   9,344,102 0 0
ANAPTYSBIO INC COM 032724106   18,013,883 799,906 SH   SOLE   799,906 0 0
BIOGEN INC COM 09062X103   62,523,644 289,958 SH   SOLE   289,958 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   99,093,257 1,134,569 SH   SOLE   1,134,569 0 0
BLUEBIRD BIO INC COM 09609G100   5,837,019 4,560,171 SH   SOLE   4,560,171 0 0
CYTOKINETICS INC COM NEW 23282W605   7,832,479 111,717 SH   SOLE   111,717 0 0
EHEALTH INC COM 28238P109   16,375,556 2,715,681 SH   SOLE   2,715,681 0 0
ELEVATION ONCOLOGY INC COM 28623U101   6,908,397 1,346,666 SH   SOLE   1,346,666 0 0
GOSSAMER BIO INC COM 38341P102   7,542,295 6,391,775 SH   SOLE   6,391,775 0 0
HUMANA INC COM 444859102   1,381,679 3,985 SH   SOLE   3,985 0 0
INSMED INC COM PAR $.01 457669307   120,006,001 4,423,369 SH   SOLE   4,423,369 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   31,311,859 2,112,811 SH   SOLE   2,112,811 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   7,704,311 5,102,193 SH   SOLE   5,102,193 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   1,625,264 64,700 SH   SOLE   64,700 0 0
NEVRO CORP COM 64157F103   10,835,357 750,371 SH   SOLE   750,371 0 0
NOVOCURE LTD ORD SHS G6674U108   8,782,622 561,908 SH   SOLE   561,908 0 0
NUVATION BIO INC COM 67080N101   2,812,453 772,652 SH   SOLE   772,652 0 0
PROTHENA CORP PLC SHS G72800108   41,203,607 1,663,448 SH   SOLE   1,663,448 0 0
RELMADA THERAPEUTICS INC COM 75955J402   3,405,660 732,400 SH   SOLE   732,400 0 0
REVANCE THERAPEUTICS INC COM 761330109   25,820,180 5,248,004 SH   SOLE   5,248,004 0 0
SAGE THERAPEUTICS INC COM 78667J108   18,848,242 1,005,776 SH   SOLE   1,005,776 0 0
SAREPTA THERAPEUTICS INC COM 803607100   26,055,767 201,265 SH   SOLE   201,265 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305   52,810,705 1,379,590 SH   SOLE   1,379,590 0 0
STOKE THERAPEUTICS INC COM 86150R107   1,699,124 125,861 SH   SOLE   125,861 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   9,643,593 405,193 SH   SOLE   405,193 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106   2,328,339 811,268 SH   SOLE   811,268 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   853,643 110,719 SH   SOLE   110,719 0 0
UNITED THERAPEUTICS CORP COM 91307C102   61,509,597 267,759 SH   SOLE   267,759 0 0
UROGEN PHARMA LTD COM M96088105   367,500 24,500 SH   SOLE   24,500 0 0
VERVE THERAPEUTICS INC COM 92539P101   7,646,850 575,817 SH   SOLE   575,817 0 0
VYNE THERAPEUTICS INC COM 92941V308   1,367,482 445,434 SH   SOLE   445,434 0 0