The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 183,344 575,233 SH   SOLE 0 575,233 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 60,317 2,337,877 SH   SOLE 0 2,337,877 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,910 160,800 SH   SOLE 0 160,800 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 35,976 235,276 SH   SOLE 0 235,276 0 0
ALIGN TECHNOLOGY INC COM 016255101 30,003 55,405 SH   SOLE 0 55,405 0 0
ALIMERA SCIENCES INC COM NEW 016259202 1,933 200,919 SH   SOLE 0 200,919 0 0
ALKERMES PLC SHS G01767105 9,099 487,100 SH   SOLE 0 487,100 0 0
AMICUS THERAPEUTICS INC COM 03152W109 96,439 9,761,043 SH   SOLE 0 9,761,043 0 0
ANAPTYSBIO INC COM 032724106 9,409 436,592 SH   SOLE 0 436,592 0 0
ATHENEX INC COM 04685N103 1,368 318,200 SH   SOLE 0 318,200 0 0
BIOGEN INC COM 09062X103 96,010 343,200 SH   SOLE 0 343,200 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 166,556 2,205,750 SH   SOLE 0 2,205,750 0 0
CLOVIS ONCOLOGY INC COM 189464100 31,481 4,484,411 SH   SOLE 0 4,484,411 0 0
CYTOKINETICS INC COM NEW 23282W605 2,877 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 8,507 332,713 SH   SOLE 0 332,713 0 0
EHEALTH INC COM 28238P109 76,975 1,058,370 SH   SOLE 0 1,058,370 0 0
EPIZYME INC COM 29428V104 59,720 6,856,513 SH   SOLE 0 6,856,513 0 0
GOSSAMER BIO INC COM 38341P102 16,400 1,772,950 SH   SOLE 0 1,772,950 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 21,674 2,298,382 SH   SOLE 0 2,298,382 0 0
IDERA PHARMACEUTICALS INC COM PAR 45168K405 100 77,044 SH   SOLE 0 77,044 0 0
INSMED INC COM PAR $.01 457669307 198,383 5,824,507 SH   SOLE 0 5,824,507 0 0
KALEIDO BIOSCIENCES INC COM 483347100 6,370 786,400 SH   SOLE 0 786,400 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 56,426 5,363,652 SH   SOLE 0 5,363,652 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 3,911 656,200 SH   SOLE 0 656,200 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 5,118 432,300 SH   SOLE 0 432,300 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 485 31,330 SH   SOLE 0 31,330 0 0
MINERVA NEUROSCIENCES INC COM 603380106 106 36,319 SH   SOLE 0 36,319 0 0
PROTHENA CORP PLC SHS G72800108 43,772 1,742,505 SH   SOLE 0 1,742,505 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 13,540 1,392,997 SH   SOLE 0 1,392,997 0 0
REVANCE THERAPEUTICS INC COM 761330109 89,492 3,201,866 SH   SOLE 0 3,201,866 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,231 652,395 SH   SOLE 0 652,395 0 0
SAGE THERAPEUTICS INC COM 78667J108 44,947 600,500 SH   SOLE 0 600,500 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 191,204 1,813,911 SH   SOLE 0 1,813,911 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 5,908 264,200 SH   SOLE 0 264,200 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 603 80,600 SH   SOLE 0 80,600 0 0
TACTILE SYSTEMS TECHNOLOGY I COM 87357P100 1,477 27,100 SH   SOLE 0 27,100 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 4,147 166,069 SH   SOLE 0 166,069 0 0
UNITED THERAPEUTICS CORP COM 91307C102 114,949 687,206 SH   SOLE 0 687,206 0 0
UROGEN PHARMA LTD COM M96088105 477 24,500 SH   SOLE 0 24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108 56,953 3,791,805 SH   SOLE 0 3,791,805 0 0
VIRACTA THERAPEUTICS INC COM 92765F108 307 33,212 SH   SOLE 0 33,212 0 0
ZOGENIX INC COM 98978L204 4,191 214,700 SH   SOLE 0 214,700 0 0