The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 180,252 2,742,305 SH   SOLE 0 2,742,305 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 9,056 2,135,739 SH   SOLE 0 2,135,739 0 0
ALCOBRA LTD SHS M2239P109 1,024 156,588 SH   SOLE 0 156,588 0 0
ALIGN TECHNOLOGY INC COM 016255101 1,741 27,757 SH   SOLE 0 27,757 0 0
ALIMERA SCIENCES INC COM 016259103 13,894 3,013,793 SH   SOLE 0 3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 151,389 2,192,141 SH   SOLE 0 2,192,141 0 0
AMICUS THERAPEUTICS INC COM 03152W109 27,937 1,974,376 SH   SOLE 0 1,974,376 0 0
ANACOR PHARMACEUTICALS INC COM 032420101 240,267 3,103,027 SH   SOLE 0 3,103,027 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 18,456 2,231,717 SH   SOLE 0 2,231,717 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 227,067 1,660,092 SH   SOLE 0 1,660,092 0 0
BIOSPECIFICS TECHNOLOGIES CO COM 090931106 2,602 50,436 SH   SOLE 0 50,436 0 0
CELGENE CORP COM 151020104 30,346 262,200 SH   SOLE 0 262,200 0 0
CLOVIS ONCOLOGY INC COM 189464100 211,010 2,401,117 SH   SOLE 0 2,401,117 0 0
CYBERONICS INC COM 23251P102 24,498 412,000 SH   SOLE 0 412,000 0 0
CYTOKINETICS INC COM NEW 23282W605 831 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 986 70,706 SH   SOLE 0 70,706 0 0
ENDO INTL PLC SHS G30401106 68,866 864,604 SH   SOLE 0 864,604 0 0
EPIZYME INC COM 29428V104 1,470 61,265 SH   SOLE 0 61,265 0 0
EXACT SCIENCES CORP COM 30063P105 11,678 392,676 SH   SOLE 0 392,676 0 0
GILEAD SCIENCES INC COM 375558103 35,065 299,500 SH   SOLE 0 299,500 0 0
HEARTWARE INTL INC COM 422368100 17,727 243,868 SH   SOLE 0 243,868 0 0
HISTOGENICS CORP COM 43358V109 2,936 454,545 SH   SOLE 0 454,545 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 4,551 1,226,748 SH   SOLE 0 1,226,748 0 0
INSMED INC COM PAR $.01 457669307 115,595 4,733,601 SH   SOLE 0 4,733,601 0 0
INTREXON CORP COM 46122T102 2,298 47,100 SH   SOLE 0 47,100 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 15,674 32,350 SH   SOLE 0 32,350 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 47,115 1,731,530 SH   SOLE 0 1,731,530 0 0
KYTHERA BIOPHARMACEUTICALS I COM 501570105 97,172 1,290,292 SH   SOLE 0 1,290,292 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 422 3,588 SH   SOLE 0 3,588 0 0
MEDIVATION INC COM 58501N101 20,590 180,300 SH   SOLE 0 180,300 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 33,193 1,455,176 SH   SOLE 0 1,455,176 0 0
OREXIGEN THERAPEUTICS INC COM 686164104 9,560 1,931,324 SH   SOLE 0 1,931,324 0 0
PROTHENA CORP PLC SHS G72800108 36,654 695,918 SH   SOLE 0 695,918 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 16,616 5,176,319 SH   SOLE 0 5,176,319 0 0
SEQUENOM INC COM NEW 817337405 30,472 10,023,842 SH   SOLE 0 10,023,842 0 0
SHIRE PLC SPONSORED ADR 82481R106 23,738 98,300 SH   SOLE 0 98,300 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 150 191,600 SH   SOLE 0 191,600 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 25,531 2,642,922 SH   SOLE 0 2,642,922 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 2,728 906,263 SH   SOLE 0 906,263 0 0
THORATEC CORP COM NEW 885175307 114,113 2,560,303 SH   SOLE 0 2,560,303 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 250,475 1,439,928 SH   SOLE 0 1,439,928 0 0
VANDA PHARMACEUTICALS INC COM 921659108 49,458 3,897,408 SH   SOLE 0 3,897,408 0 0
WRIGHT MED GROUP INC COM 98235T107 53,997 2,056,251 SH   SOLE 0 2,056,251 0 0
XOMA CORP DEL COM 98419J107 3,100 799,000 SH   SOLE 0 799,000 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 16,752 568,436 SH   SOLE 0 568,436 0 0