Chief Compliance Officer

0001104659-23-089542.txt : 20230810 0001104659-23-089542.hdr.sgml : 20230810 20230810065925 ACCESSION NUMBER: 0001104659-23-089542 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20230630 FILED AS OF DATE: 20230810 DATE AS OF CHANGE: 20230810 EFFECTIVENESS DATE: 20230810 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 231157116 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false false false 0001300336 XXXXXXXX 06-30-2023 06-30-2023 false Tekla Capital Management LLC

100 Federal Street 19th Floor Boston MA 02110

13F HOLDINGS REPORT 028-10950 000119626 801-61018 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 08-10-2023 0 166 2555383183 INFORMATION TABLE 2 infotable.xml 89bio, Inc. Common 282559103 2006767 105898 SH SOLE 2006767 0 0 Abbott Laboratories Common 002824100 60228644 552455 SH SOLE 60228644 0 0 AbbVie Inc. Common 00287Y109 73512595 545629 SH SOLE 73512595 0 0 Acadia Healthcare Company, Inc. Common 00404A109 8036632 100912 SH SOLE 8036632 0 0 Adaptive Biotechnologies Corp. Common 00650F109 2833506 422281 SH SOLE 2833506 0 0 Adicet Bio, Inc. Common 007002108 97999 40329 SH SOLE 97999 0 0 Affimed N.V. Common N01045108 350568 586038 SH SOLE 350568 0 0 Agilent Technologies, Inc. Common 00846U101 5193718 43191 SH SOLE 5193718 0 0 Akero Therapeutics, Inc. Common 00973Y108 2871295 61497 SH SOLE 2871295 0 0 Alkermes plc Shares G01767105 9690887 309613 SH SOLE 9690887 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 27202067 143214 SH SOLE 27202067 0 0 Altimmune, Inc. Common 02155H200 264750 75000 SH SOLE 264750 0 0 ALX Oncology Holdings Inc. Common 00166B105 497245 66211 SH SOLE 497245 0 0 Amerisourcebergen Corp. Common 03073E105 3928843 20417 SH SOLE 3928843 0 0 Amgen Inc. Common 031162100 136883989 616539 SH SOLE 136883989 0 0 Amylyx Pharmaceuticals, Inc. Common 03237H101 2243431 104007 SH SOLE 2243431 0 0 Apellis Pharmaceuticals, Inc. Common 03753U106 15782893 173248 SH SOLE 15782893 0 0 ARCA biopharma, Inc. Common 00211Y506 65896 32461 SH SOLE 65896 0 0 Arcus Biosciences, Inc. Common 03969F109 666960 32839 SH SOLE 666960 0 0 Arcutis Biotherapeutics, Inc. Common 03969K108 1418769 148874 SH SOLE 1418769 0 0 Ardelyx, Inc. Common 039697107 1828593 539408 SH SOLE 1828593 0 0 argenx SE Sponsored ADR 04016X101 25547971 65553 SH SOLE 25547971 0 0 Ascendis Pharma A/S Sponsored ADR 04351P101 12387097 138791 SH SOLE 12387097 0 0 Assertio Holdings, Inc. Common 04546C205 2225317 410575 SH SOLE 2225317 0 0 AstraZeneca PLC Sponsored ADR 046353108 69900701 976676 SH SOLE 69900701 0 0 Avantor, Inc. Common 05352A100 9437884 459488 SH SOLE 9437884 0 0 Baxter International, Inc. Common 071813109 14778297 324370 SH SOLE 14778297 0 0 Beam Therapeutics Inc. Common 07373V105 505037 15817 SH SOLE 505037 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 3735742 20952 SH SOLE 3735742 0 0 Bellicum Pharmaceuticals, Inc. Common 079481404 2220 6000 SH SOLE 2220 0 0 Bicycle Therapeutics PLC Sponsored ADS 088786108 1131506 44338 SH SOLE 1131506 0 0 BioCryst Pharmaceuticals, Inc. Common 09058V103 3551877 504528 SH SOLE 3551877 0 0 Biogen Inc. Common 09062X103 70626564 247943 SH SOLE 70626564 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 18271191 210789 SH SOLE 18271191 0 0 BioNTech SE Sponsored ADS 09075V102 11209394 103858 SH SOLE 11209394 0 0 Black Diamond Therapeutics, Inc. Common 09203E105 666550 131990 SH SOLE 666550 0 0 Boston Scientific Corp. Common 101137107 35579861 657790 SH SOLE 35579861 0 0 Bridgebio Pharma, Inc. Common 10806X102 2595841 150921 SH SOLE 2595841 0 0 Bristol-Myers Squibb Company Common 110122108 29320947 458498 SH SOLE 29320947 0 0 Caribou Biosciences, Inc. Common 142038108 2410375 567147 SH SOLE 2410375 0 0 Cerevel Therapeutics Holdings, Inc. Common 15678U128 5610395 176483 SH SOLE 5610395 0 0 Charles River Laboratories International, Inc. Common 159864107 23376226 111183 SH SOLE 23376226 0 0 Chinook Therapeutics, Inc. Common 16961L106 5796156 150863 SH SOLE 5796156 0 0 Codexis Inc Common 192005106 193550 69125 SH SOLE 193550 0 0 Community Health Systems, Inc. Common 203668108 388674 88335 SH SOLE 388674 0 0 Community Healthcare Trust Inc. Common 20369C106 491998 14900 SH SOLE 491998 0 0 Corbus Pharmaceuticals Holdings, Inc. Common 21833P301 40321 5143 SH SOLE 40321 0 0 Crinetics Pharmaceuticals, Inc. Common 22663K107 1415093 78529 SH SOLE 1415093 0 0 CRISPR Therapeutics AG Namen AKT H17182108 1267136 22571 SH SOLE 1267136 0 0 CVS Health Corp. Common 126650100 6472020 93621 SH SOLE 6472020 0 0 Cytokinetics, Inc. Common 23282W605 7144596 219025 SH SOLE 7144596 0 0 Danaher Corp. Common 235851102 34275120 142813 SH SOLE 34275120 0 0 Denali Therapeutics, Inc. Common 24823R105 9585704 324829 SH SOLE 9585704 0 0 Dexcom, Inc. Common 252131107 29396277 228747 SH SOLE 29396277 0 0 Diversified Healthcare Trust Common 25525P107 804870 357720 SH SOLE 804870 0 0 Edgewise Therapeutics, Inc. Common 28036F105 1165740 150418 SH SOLE 1165740 0 0 Edwards Lifesciences Corp. Common 28176E108 17884685 189597 SH SOLE 17884685 0 0 Elevance Health, Inc. Common 036752103 50680160 114070 SH SOLE 50680160 0 0 Eli Lilly and Company Common 532457108 100057821 213352 SH SOLE 100057821 0 0 Exelixis, Inc. Common 30161Q104 13886071 726639 SH SOLE 13886071 0 0 Fulcrum Therapeutics, Inc. Common 359616109 847730 256888 SH SOLE 847730 0 0 Fusion Pharmaceuticals Inc. Common 36118A100 203084 43394 SH SOLE 203084 0 0 G1 Therapeutics, Inc. Common 3621LQ109 1055434 423869 SH SOLE 1055434 0 0 Galera Therapeutics, Inc. Common 36338D108 2802927 898374 SH SOLE 2802927 0 0 Gilead Sciences, Inc. Common 375558103 118216440 1533884 SH SOLE 118216440 0 0 Global Medical REIT Inc. Common 37954A204 1596810 174897 SH SOLE 1596810 0 0 GSK plc Sponsored ADR 37733W204 1491605 41852 SH SOLE 1491605 0 0 Guardant Health, Inc. Common 40131M109 12389807 346084 SH SOLE 12389807 0 0 Harpoon Therapeutics, Inc. Common 41358P106 184536 259910 SH SOLE 184536 0 0 HCA Healthcare, Inc. Common 40412C101 25007662 82403 SH SOLE 25007662 0 0 Healthcare Realty Trust Inc. Common 42226K105 3294578 174686 SH SOLE 3294578 0 0 Healthpeak Properties, Inc. Common 42250P103 3022879 150392 SH SOLE 3022879 0 0 HilleVax, Inc. Common 43157M102 464130 27000 SH SOLE 464130 0 0 Horizon Therapeutics plc Common G46188101 7448911 72425 SH SOLE 7448911 0 0 Humana Inc. Common 444859102 16451701 36794 SH SOLE 16451701 0 0 I-Mab Sponsored ADS 44975P103 486114 162580 SH SOLE 486114 0 0 Icon plc Shares G4705A100 2335367 9334 SH SOLE 2335367 0 0 IDEXX Laboratories, Inc. Common 45168D104 29428167 58595 SH SOLE 29428167 0 0 Illumina, Inc. Common 452327109 63180193 336979 SH SOLE 63180193 0 0 Immunovant, Inc. Common 45258J102 6377714 336200 SH SOLE 6377714 0 0 Inspire Medical Systems, Inc. Common 457730109 7147924 22018 SH SOLE 7147924 0 0 Insulet Corp. Common 45784P101 12642844 43847 SH SOLE 12642844 0 0 Intellia Therapeutics, Inc. Common 45826J105 6291090 154269 SH SOLE 6291090 0 0 Intercept Pharmaceuticals, Inc. Common 45845P108 575861 52067 SH SOLE 575861 0 0 Intra-Cellular Therapies, Inc. Common 46116X101 8322464 131435 SH SOLE 8322464 0 0 Intuitive Surgical, Inc. Common 46120E602 28716121 83980 SH SOLE 28716121 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 3604075 87840 SH SOLE 3604075 0 0 IQVIA Holdings Inc. Common 46266C105 24528925 109129 SH SOLE 24528925 0 0 Ishares Biothechnology ETF Common 464287556 3119280 24569 SH SOLE 3119280 0 0 iTeos Therapeutics, Inc. Common 46565G104 605531 45735 SH SOLE 605531 0 0 Jazz Pharmaceuticals plc Shares G50871105 18320163 147779 SH SOLE 18320163 0 0 Johnson & Johnson Common 478160104 119468860 721779 SH SOLE 119468860 0 0 Karuna Therapeutics, Inc. Common 48576A100 12702422 58577 SH SOLE 12702422 0 0 Koninklijke Philips N.V. NY Reg Shares 500472303 2489253 114765 SH SOLE 2489253 0 0 LivaNova plc Common G5509L101 5579126 108480 SH SOLE 5579126 0 0 LTC Properties, Inc. Common 502175102 6019315 182293 SH SOLE 6019315 0 0 Madrigal Pharmaceuticals, Inc. Common 558868105 7954254 34434 SH SOLE 7954254 0 0 Mallinckrodt plc Shares G5890A102 41357 35048 SH SOLE 41357 0 0 Marinus Pharmaceuticals, Inc. Common 56854Q200 4464557 411101 SH SOLE 4464557 0 0 McKesson Corp. Common 58155Q103 26473991 61955 SH SOLE 26473991 0 0 Medical Properties Trust, Inc. Common 58463J304 3812740 411743 SH SOLE 3812740 0 0 Medpace Holdings, Inc. Common 58506Q109 6464896 26918 SH SOLE 6464896 0 0 Medtronic plc Shares G5960L103 30343138 344417 SH SOLE 30343138 0 0 Merck & Co., Inc. Common 58933Y105 84021690 728154 SH SOLE 84021690 0 0 Mereo BioPharma Group plc ADS 589492107 2047428 1551082 SH SOLE 2047428 0 0 Mirati Therapeutics, Inc. Common 60468T105 2366154 65490 SH SOLE 2366154 0 0 Moderna, Inc. Common 60770K107 41758943 343695 SH SOLE 41758943 0 0 Molina Healthcare, Inc. Common 60855R100 18633501 61856 SH SOLE 18633501 0 0 MorphoSys AG Sponsored ADS 617760202 1323617 177191 SH SOLE 1323617 0 0 Natera, Inc. Common 632307104 1198788 24636 SH SOLE 1198788 0 0 National Health Investors, Inc. Common 63633D104 526192 10038 SH SOLE 526192 0 0 Neurocrine Biosciences, Inc. Common 64125C109 10647224 112908 SH SOLE 10647224 0 0 NexGel, Inc. Common 65344E107 10650 4243 SH SOLE 10650 0 0 Nkarta, Inc. Common 65487U108 63484 28988 SH SOLE 63484 0 0 Novartis AG Sponsored ADR 66987V109 13746465 136225 SH SOLE 13746465 0 0 Novavax, Inc. Common 670002401 474034 63800 SH SOLE 474034 0 0 Novo Nordisk A/S Sponsored ADR 670100205 19869002 122777 SH SOLE 19869002 0 0 Oculis Holding AG Common 952KVL905 18823020 1690741 SH SOLE 18823020 0 0 Omega Healthcare Investors, Inc. Common 681936100 9404429 306433 SH SOLE 9404429 0 0 Perrigo Company plc Shares G97822103 1739055 51224 SH SOLE 1739055 0 0 Pfizer Inc. Common 717081103 59585780 1624476 SH SOLE 59585780 0 0 Physicians Realty Trust Common 71943U104 12222433 873655 SH SOLE 12222433 0 0 Praxis Precision Medicines, Inc. Common 74006W108 86250 75000 SH SOLE 86250 0 0 Precision BioSciences, Inc. Common 74019P108 118105 224534 SH SOLE 118105 0 0 Pyxis Oncology, Inc. Common 747324101 1813256 708303 SH SOLE 1813256 0 0 R1 RCM Inc. Common 77634L105 6583901 356851 SH SOLE 6583901 0 0 Rallybio Corporation Common 75120L100 9775199 1727067 SH SOLE 9775199 0 0 Reata Pharmaceuticals, Inc. Class A Class A 75615P103 3492130 34250 SH SOLE 3492130 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 115985290 161418 SH SOLE 115985290 0 0 Repare Therapeutics Inc. Common 760273102 308407 29150 SH SOLE 308407 0 0 ResMed Inc. Common 761152107 7582824 34704 SH SOLE 7582824 0 0 Sabra Health Care REIT, Inc. Common 78573L106 6010468 510660 SH SOLE 6010468 0 0 Sanofi Sponsored ADR 80105N105 6654171 123454 SH SOLE 6654171 0 0 Sarepta Therapeutics, Inc. Common 803607100 20549125 179437 SH SOLE 20549125 0 0 Scholar Rock Holding Corp. Common 80706P103 820601 108833 SH SOLE 820601 0 0 Seagen Inc. Common 81181C104 21619224 112331 SH SOLE 21619224 0 0 Smith & Nephew plc Sponsored ADR 83175M205 5860148 181710 SH SOLE 5860148 0 0 SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 12286726 147677 SH SOLE 12286726 0 0 Spectrum Pharmaceuticals, Inc. Common 84763A108 110083 114670 SH SOLE 110083 0 0 STERIS plc Shares G8473T100 6990579 31072 SH SOLE 6990579 0 0 Stryker Corp. Common 863667101 24751342 81128 SH SOLE 24751342 0 0 Sutro Biopharma, Inc. Common 869367102 457346 98354 SH SOLE 457346 0 0 Tactile Systems Technology, Inc. Common 87357P100 1457707 58472 SH SOLE 1457707 0 0 Takeda Pharmaceutical Company Ltd. Sponsored ADS 874060205 1650697 105073 SH SOLE 1650697 0 0 Tenet Healthcare Corp. Common 88033G407 12131317 149070 SH SOLE 12131317 0 0 Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 3461172 459651 SH SOLE 3461172 0 0 The Cigna Group Common 125523100 27032723 96339 SH SOLE 27032723 0 0 Thermo Fisher Scientific Inc. Common 883556102 51646467 98987 SH SOLE 51646467 0 0 Theseus Pharmaceuticals, Inc. Common 88369M101 699750 75000 SH SOLE 699750 0 0 TScan Therapeutics, Inc. Common 89854M101 500000 200000 SH SOLE 500000 0 0 uniQure N.V. Shares N90064101 4082969 356280 SH SOLE 4082969 0 0 United Therapeutics Corp. Common 91307C102 9153399 41465 SH SOLE 9153399 0 0 Unitedhealth Group Inc. Common 91324P102 99473735 206961 SH SOLE 99473735 0 0 Universal Health Realty Income Trust Common 91359E105 535656 11258 SH SOLE 535656 0 0 Vaxcyte, Inc. Common 92243G108 9699946 194232 SH SOLE 9699946 0 0 Ventas, Inc. Common 92276F100 3152011 66681 SH SOLE 3152011 0 0 Veradigm, Inc. Common 01988P108 5400108 428580 SH SOLE 5400108 0 0 Vertex Pharmaceuticals Inc. Common 92532F100 111922512 318043 SH SOLE 111922512 0 0 VYNE Therapeutics, Inc. Common 92941V308 30531 7520 SH SOLE 30531 0 0 Welltower Inc. Common 95040Q104 3355641 41484 SH SOLE 3355641 0 0 West Pharmaceutical Services, Inc. Common 955306105 5750819 15036 SH SOLE 5750819 0 0 Xencor, Inc. Common 98401F105 1415175 56675 SH SOLE 1415175 0 0 Xenon Pharmaceuticals Inc. Common 98420N105 2598981 67506 SH SOLE 2598981 0 0 Zentalis Pharmaceuticals, Inc. Common 98943L107 1132801 40156 SH SOLE 1132801 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 9807034 67356 SH SOLE 9807034 0 0 Zoetis Inc. Class A 98978V103 23577960 136914 SH SOLE 23577960 0 0