The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 28,333 391,719 SH   SOLE   391,719 0 0
AbbVie Inc. Common 00287Y109 45,365 492,078 SH   SOLE   492,078 0 0
ABIOMED, Inc. Common 003654100 4,014 12,350 SH   SOLE   12,350 0 0
AC Immune SA Shares H00263105 1,624 171,813 SH   SOLE   171,813 0 0
ACADIA Pharmaceuticals Inc. Common 00404A109 4,452 173,155 SH   SOLE   173,155 0 0
Acceleron Pharma Inc. Common 00434H108 7,437 170,766 SH   SOLE   170,766 0 0
Achillion Pharmaceuticals, Inc. Common 00448Q201 507 318,833 SH   SOLE   318,833 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 1,314 228,496 SH   SOLE   228,496 0 0
Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 9,734 13,000,000 PRN   SOLE   13,000,000 0 0
Aerie Pharmaceuticals, Inc. Common 00771V108 1,400 38,770 SH   SOLE   38,770 0 0
Aerpio Pharmaceuticals, Inc. Common 00810B105 1,301 765,000 SH   SOLE   765,000 0 0
Affimed N.V. Common N01045108 790 254,000 SH   SOLE   254,000 0 0
Agilent Technologies, Inc. Common 00846U101 553 8,200 SH   SOLE   8,200 0 0
Agios Pharmaceuticals, Inc. Common 00847X104 2,261 49,025 SH   SOLE   49,025 0 0
Akebia Therapeutics, Inc. Common 00972D105 1,183 213,942 SH   SOLE   213,942 0 0
Albireo Pharma, Inc. Common 01345P106 3,066 125,000 SH   SOLE   125,000 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 48,319 496,288 SH   SOLE   496,288 0 0
Align Technology, Inc. Common 016255101 6,254 29,860 SH   SOLE   29,860 0 0
Alkermes plc Shares G01767105 4,464 151,283 SH   SOLE   151,283 0 0
Allergan plc Shares G0177J108 31,373 234,720 SH   SOLE   234,720 0 0
Alliqua BioMedical, Inc. Common 019621309 278 148,500 SH   SOLE   148,500 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 9,199 126,176 SH   SOLE   126,176 0 0
Amarin Corporation plc Sponsored ADR 023111206 8,902 654,052 SH   SOLE   654,052 0 0
AmerisourceBergen Corporation Common 03073E105 8,318 111,807 SH   SOLE   111,807 0 0
Amgen Inc. Common 031162100 131,958 677,855 SH   SOLE   677,855 0 0
Amicus Therapeutics, Inc. Common 03152W109 8,385 875,304 SH   SOLE   875,304 0 0
AnaptysBio, Inc. Common 032724106 4,200 65,845 SH   SOLE   65,845 0 0
Anthem, Inc. Common 036752103 37,069 141,147 SH   SOLE   141,147 0 0
ARCA biopharma, Inc. Common 00211Y407 271 811,227 SH   SOLE   811,227 0 0
Ardelyx, Inc. Common 039697107 1,144 639,370 SH   SOLE   639,370 0 0
Arena Pharmaceuticals, Inc. Common 040047607 2,036 52,262 SH   SOLE   52,262 0 0
ArQule, Inc. Common 04269E107 693 250,000 SH   SOLE   250,000 0 0
Array BioPharma Inc. Common 04269X105 5,189 364,166 SH   SOLE   364,166 0 0
Arrowhead Pharmaceuticals, Inc. Common 04280A100 381 30,700 SH   SOLE   30,700 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 2,656 42,399 SH   SOLE   42,399 0 0
AstraZeneca PLC Sponsored ADR 046353108 16,256 428,024 SH   SOLE   428,024 0 0
Athenex, Inc. Common 04685N103 578 45,530 SH   SOLE   45,530 0 0
Audentes Therapeutics, Inc. Common 05070R104 1,121 52,574 SH   SOLE   52,574 0 0
Avadel Pharmaceuticals plc Sponsored ADR 05337M104 2,102 814,588 SH   SOLE   814,588 0 0
Bausch Health Companies Inc. Common 071734107 3,546 192,000 SH   SOLE   192,000 0 0
Baxter International Inc. Common 071813109 10,612 161,233 SH   SOLE   161,233 0 0
Becton, Dickinson and Company Common 075887109 15,722 69,778 SH   SOLE   69,778 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 12,028 85,755 SH   SOLE   85,755 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 175 60,000 SH   SOLE   60,000 0 0
Biogen Inc. Common 09062X103 118,834 394,902 SH   SOLE   394,902 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 17,663 207,434 SH   SOLE   207,434 0 0
bluebird bio, Inc. Common 09609G100 9,764 98,429 SH   SOLE   98,429 0 0
Blueprint Medicines Corporation Common 09627Y109 6,750 125,207 SH   SOLE   125,207 0 0
Boston Scientific Corporation Common 101137107 15,726 444,991 SH   SOLE   444,991 0 0
Bristol-Myers Squibb Company Common 110122108 33,941 652,966 SH   SOLE   652,966 0 0
Cardinal Health, Inc. Common 14149Y108 281 6,300 SH   SOLE   6,300 0 0
Celgene Corporation Common 151020104 88,573 1,382,006 SH   SOLE   1,382,006 0 0
Celldex Therapeutics, Inc. Common 15117B103 21 105,800 SH   SOLE   105,800 0 0
Cellectis SA Sponsored ADR 15117K103 3,938 236,530 SH   SOLE   236,530 0 0
Centene Corporation Common 15135B101 19,240 166,869 SH   SOLE   166,869 0 0
Charles River Laboratories International, Inc. Common 159864107 2,566 22,670 SH   SOLE   22,670 0 0
Cidara Therapeutics, Inc. Common 171757107 373 158,784 SH   SOLE   158,784 0 0
Cigna Corporation Common 125523100 12,172 64,089 SH   SOLE   64,089 0 0
Clearside Biomedical, Inc. Common 185063104 177 165,330 SH   SOLE   165,330 0 0
Clovis Oncology, Inc. Common 189464100 1,354 75,400 SH   SOLE   75,400 0 0
Coherus Biosciences, Inc. Common 19249H103 2,852 315,162 SH   SOLE   315,162 0 0
Community Health Systems, Inc. Common 203668108 575 203,935 SH   SOLE   203,935 0 0
Concert Pharmaceuticals, Inc. Common 206022105 569 45,362 SH   SOLE   45,362 0 0
CRISPR Therapeutics AG Namen AKT H17182108 5,095 178,348 SH   SOLE   178,348 0 0
CVS Health Corporation Common 126650100 30,185 460,698 SH   SOLE   460,698 0 0
Danaher Corporation Common 235851102 21,590 209,371 SH   SOLE   209,371 0 0
DENTSPLY SIRONA Inc. Common 24906P109 4,675 125,625 SH   SOLE   125,625 0 0
Dermira, Inc. Common 24983L104 1,162 161,579 SH   SOLE   161,579 0 0
Diplomat Pharmacy, Inc. Common 25456K101 6,807 505,701 SH   SOLE   505,701 0 0
Dr. Reddy's Laboratories Limited Common 256135203 1,376 36,500 SH   SOLE   36,500 0 0
Editas Medicine, Inc. Common 28106W103 1,744 76,668 SH   SOLE   76,668 0 0
Edwards Lifesciences Corporation Common 28176E108 8,700 56,798 SH   SOLE   56,798 0 0
Egalet Corporation Note 5.50% 4/1/20 28226BAB0 700 7,000,000 PRN   SOLE   7,000,000 0 0
Eidos Therapeutics, Inc. Common 28249H104 384 27,900 SH   SOLE   27,900 0 0
Eli Lilly and Company Common 532457108 25,047 216,442 SH   SOLE   216,442 0 0
Endo International plc Shares G30401106 5,236 717,274 SH   SOLE   717,274 0 0
Epizyme, Inc. Common 29428V104 2,377 385,872 SH   SOLE   385,872 0 0
Esperion Therapeutics, Inc. Common 29664W105 6,545 142,289 SH   SOLE   142,289 0 0
Evolent Health, Inc. Common 30050B101 841 42,150 SH   SOLE   42,150 0 0
Exelixis, Inc. Common 30161Q104 6,677 339,435 SH   SOLE   339,435 0 0
FibroGen, Inc. Common 31572Q808 9,847 212,763 SH   SOLE   212,763 0 0
Foamix Pharmaceuticals Ltd Shares M46135105 2,158 601,205 SH   SOLE   601,205 0 0
Galapagos NV Common 36315X101 9,157 99,815 SH   SOLE   99,815 0 0
Genomic Health, Inc. Common 37244C101 1,119 17,370 SH   SOLE   17,370 0 0
Gilead Sciences, Inc. Common 375558103 118,210 1,889,846 SH   SOLE   1,889,846 0 0
GlaxoSmithKline plc Shares 37733W105 8,357 218,700 SH   SOLE   218,700 0 0
Global Blood Therapeutics, Inc. Common 37890U108 3,856 93,924 SH   SOLE   93,924 0 0
Global Medical REIT Inc. Common 37954A204 653 73,400 SH   SOLE   73,400 0 0
GW Pharmaceuticals plc ADS 36197T103 6,169 63,345 SH   SOLE   63,345 0 0
HCA Healthcare, Inc. Common 40412C101 9,251 74,335 SH   SOLE   74,335 0 0
HCP, Inc. Common 40414L109 1,271 45,500 SH   SOLE   45,500 0 0
Healthcare Realty Trust Incorporated Common 421946104 1,934 68,000 SH   SOLE   68,000 0 0
Healthcare Trust of America, Inc. Common 42225P501 1,164 46,000 SH   SOLE   46,000 0 0
Hologic, Inc. Common 436440101 803 19,546 SH   SOLE   19,546 0 0
Humana Inc. Common 444859102 19,620 68,487 SH   SOLE   68,487 0 0
IDEXX Laboratories, Inc. Common 45168D104 9,594 51,575 SH   SOLE   51,575 0 0
Illumina, Inc. Common 452327109 78,695 262,379 SH   SOLE   262,379 0 0
ImmunoGen, Inc. Common 45253H101 807 168,190 SH   SOLE   168,190 0 0
Immunomedics, Inc. Common 452907108 6,158 431,527 SH   SOLE   431,527 0 0
Incyte Corporation Common 45337C102 41,044 645,442 SH   SOLE   645,442 0 0
Innoviva, Inc. Common 45781M101 2,820 161,603 SH   SOLE   161,603 0 0
Inogen, Inc. Common 45780L104 1,676 13,500 SH   SOLE   13,500 0 0
Inovalon Holdings, Inc. Common 45781D101 2,498 176,163 SH   SOLE   176,163 0 0
Intellia Therapeutics, Inc. Common 45826J105 2,051 150,290 SH   SOLE   150,290 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108 1,345 13,348 SH   SOLE   13,348 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 1,255 110,193 SH   SOLE   110,193 0 0
Intuitive Surgical, Inc. Common 46120E602 18,788 39,229 SH   SOLE   39,229 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 4,478 82,838 SH   SOLE   82,838 0 0
Iovance Biotherapeutics, Inc. Common 462260100 1,920 216,908 SH   SOLE   216,908 0 0
IQVIA Holdings Inc. Common 46266C105 4,542 39,100 SH   SOLE   39,100 0 0
Jazz Pharmaceuticals plc Shares G50871105 14,279 115,187 SH   SOLE   115,187 0 0
Johnson & Johnson Common 478160104 133,261 1,032,628 SH   SOLE   1,032,628 0 0
Jounce Therapeutics, Inc. Common 481116101 34 10,127 SH   SOLE   10,127 0 0
Koninklijke Philips N.V. NY Reg Sh 500472303 2,998 85,400 SH   SOLE   85,400 0 0
Laboratory Corporation of America Holdings Sponsored ADR 50540R409 3,677 29,100 SH   SOLE   29,100 0 0
LeMaitre Vascular, Inc. Common 525558201 642 27,150 SH   SOLE   27,150 0 0
Lexicon Pharmaceuticals, Inc. Sponsored ADR 528872302 465 70,000 SH   SOLE   70,000 0 0
Ligand Pharmaceuticals Incorporated Common 53220K504 3,589 26,450 SH   SOLE   26,450 0 0
LivaNova plc Shares G5509L101 1,043 11,400 SH   SOLE   11,400 0 0
Loxo Oncology, Inc. Common 548862101 3,445 24,595 SH   SOLE   24,595 0 0
LTC Properties, Inc. Common 502175102 7,445 178,623 SH   SOLE   178,623 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105 752 6,670 SH   SOLE   6,670 0 0
Mallinckrodt plc Sponsored ADR G5785G107 847 53,600 SH   SOLE   53,600 0 0
Marinus Pharmaceuticals, Inc. Common 56854Q101 2,169 755,776 SH   SOLE   755,776 0 0
Masimo Corporation Common 574795100 1,826 17,011 SH   SOLE   17,011 0 0
McKesson Corporation Common 58155Q103 8,696 78,720 SH   SOLE   78,720 0 0
Medical Properties Trust, Inc. Common 58463J304 6,654 413,809 SH   SOLE   413,809 0 0
The Medicines Company Common 584688105 8,211 428,992 SH   SOLE   428,992 0 0
Medtronic plc Shares G5960L103 43,785 481,365 SH   SOLE   481,365 0 0
Merck & Co., Inc. Common 58933Y105 56,399 738,108 SH   SOLE   738,108 0 0
Merus N.V. Common N5749R100 5,147 367,671 SH   SOLE   367,671 0 0
Mettler-Toledo International Inc. Common 592688105 1,980 3,500 SH   SOLE   3,500 0 0
Mirati Therapeutics, Inc. Common 60468T105 576 13,590 SH   SOLE   13,590 0 0
Molecular Templates, Inc. Common 608550109 582 144,110 SH   SOLE   144,110 0 0
Mylan N.V. Shares N59465109 38,462 1,403,728 SH   SOLE   1,403,728 0 0
MyoKardia, Inc. Common 62857M105 1,886 38,600 SH   SOLE   38,600 0 0
Nektar Therapeutics Common 640268108 3,102 94,384 SH   SOLE   94,384 0 0
Neurocrine Biosciences, Inc. Common 64125C109 15,446 216,294 SH   SOLE   216,294 0 0
Nevro Corp. Common 64157F103 2,674 68,760 SH   SOLE   68,760 0 0
New Senior Investment Group Inc. Common 648691103 1,297 314,747 SH   SOLE   314,747 0 0
Nightstar Therapeutics plc ADR 65413A101 1,140 98,929 SH   SOLE   98,929 0 0
Novartis AG Sponsored ADR 66987V109 25,032 291,717 SH   SOLE   291,717 0 0
Novavax, Inc. Common 670002104 1,051 571,000 SH   SOLE   571,000 0 0
Novo Nordisk A/S ADR 670100205 13,909 301,900 SH   SOLE   301,900 0 0
Novocure Limited Ordinary Shares G6674U108 820 24,500 SH   SOLE   24,500 0 0
NuCana plc Sponsored ADR 67022C106 142 9,823 SH   SOLE   9,823 0 0
NuVasive, Inc. Common 670704105 1,428 28,816 SH   SOLE   28,816 0 0
Omega Healthcare Investors, Inc. Common 681936100 13,361 380,122 SH   SOLE   380,122 0 0
Ovid Therapeutics Inc. ADR 690469101 1,203 496,977 SH   SOLE   496,977 0 0
Perrigo Company plc Shares G97822103 1,445 37,300 SH   SOLE   37,300 0 0
Pfizer Inc. Common 717081103 66,208 1,516,793 SH   SOLE   1,516,793 0 0
Physicians Realty Trust Common 71943U104 6,268 391,016 SH   SOLE   391,016 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 5,552 2,087,380 SH   SOLE   2,087,380 0 0
Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 2,254 115,448 SH   SOLE   115,448 0 0
PRA Health Sciences, Inc. Common 69354M108 6,480 70,460 SH   SOLE   70,460 0 0
Protagonist Therapeutics, Inc. Common 74366E102 1,327 197,138 SH   SOLE   197,138 0 0
PTC Therapeutics, Inc. Common 69366J200 2,356 68,652 SH   SOLE   68,652 0 0
Puma Biotechnology, Inc. Common 74587V107 1,696 83,340 SH   SOLE   83,340 0 0
Quest Diagnostics Incorporated Common 74834L100 5,537 66,500 SH   SOLE   66,500 0 0
Quorum Health Corporation Common 74909E106 69 23,725 SH   SOLE   23,725 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 50,954 136,422 SH   SOLE   136,422 0 0
ResMed Inc. Common 761152107 6,676 58,630 SH   SOLE   58,630 0 0
Rhythm Pharmaceuticals, Inc. Common 76243J105 669 24,890 SH   SOLE   24,890 0 0
Sabra Health Care REIT, Inc. Common 78573L106 8,946 542,862 SH   SOLE   542,862 0 0
Sage Therapeutics, Inc. Common 78667J108 9,430 98,444 SH   SOLE   98,444 0 0
Sangamo Therapeutics, Inc. Common 800677106 2,773 241,538 SH   SOLE   241,538 0 0
Sanofi Sponsored ADR 80105N105 7,809 179,900 SH   SOLE   179,900 0 0
Sarepta Therapeutics, Inc. Common 803607100 20,935 191,837 SH   SOLE   191,837 0 0
Seattle Genetics, Inc. Common 812578102 12,819 226,239 SH   SOLE   226,239 0 0
Senior Housing Properties Trust Common 81721M109 4,421 377,220 SH   SOLE   377,220 0 0
Shire plc Sponsored ADR 82481R106 6,303 36,216 SH   SOLE   36,216 0 0
Smith & Nephew plc Shares 83175M205 6,933 185,478 SH   SOLE   185,478 0 0
Spark Therapeutics, Inc. Common 84652J103 422 10,772 SH   SOLE   10,772 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 10,362 144,424 SH   SOLE   144,424 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108 1,003 114,670 SH   SOLE   114,670 0 0
STERIS plc Shares G84720104 5,129 48,003 SH   SOLE   48,003 0 0
Stryker Corporation Common 863667101 25,148 160,432 SH   SOLE   160,432 0 0
Sutro Biopharma, Inc. Common 869367102 2,074 229,900 SH   SOLE   229,900 0 0
Syndax Pharmaceuticals, Inc. Common 87164F105 890 200,000 SH   SOLE   200,000 0 0
Takeda Pharmaceutical Co. Ltd. Sponsored ADS 687044008 649 19,200 SH   SOLE   19,200 0 0
Teleflex Incorporated Common 879369106 1,649 6,379 SH   SOLE   6,379 0 0
Tenet Healthcare Corporation Common 88033G407 2,419 141,136 SH   SOLE   141,136 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N105 971 859,322 SH   SOLE   859,322 0 0
Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 18,687 1,211,868 SH   SOLE   1,211,868 0 0
Thermo Fisher Scientific Inc. Common 883556102 42,944 191,895 SH   SOLE   191,895 0 0
Trillium Therapeutics Inc. Common 89620X506 763 446,099 SH   SOLE   446,099 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 3,346 76,958 SH   SOLE   76,958 0 0
uniQure N.V. Shares N90064101 1,088 37,741 SH   SOLE   37,741 0 0
United Therapeutics Corporation Class B 91307C102 4,493 41,261 SH   SOLE   41,261 0 0
Unitedhealth Group Incorporated Common 91324P102 93,513 375,374 SH   SOLE   375,374 0 0
Varian Medical Systems, Inc. Common 92220P105 2,972 26,227 SH   SOLE   26,227 0 0
Ventas, Inc. Common 92276F100 5,771 98,496 SH   SOLE   98,496 0 0
Verona Pharma plc Sponsored ADR 925050106 2,475 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 70,634 426,248 SH   SOLE   426,248 0 0
Viking Therapeutics, Inc. Common 92686J106 436 57,008 SH   SOLE   57,008 0 0
Waters Corporation Common 941848103 2,037 10,800 SH   SOLE   10,800 0 0
WellCare Health Plans, Inc. Common 94946T106 3,069 13,000 SH   SOLE   13,000 0 0
Welltower Inc. Common 95040Q104 3,162 45,560 SH   SOLE   45,560 0 0
Wright Medical Group N.V. Ordinary Shares N96617118 3,631 133,391 SH   SOLE   133,391 0 0
Xencor, Inc. Common 98401F105 2,031 56,172 SH   SOLE   56,172 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 9,252 89,204 SH   SOLE   89,204 0 0
Zoetis Inc. Class A 98978V103 21,506 251,415 SH   SOLE   251,415 0 0
Zogenix, Inc. Common 98978L204 4,048 111,025 SH   SOLE   111,025 0 0