The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 47,853 798,619 SH   SOLE   798,619 0 0
AbbVie Inc. Common 00287Y109 42,662 450,738 SH   SOLE   450,738 0 0
ABIOMED, Inc. Common 003654100 1,896 6,514 SH   SOLE   6,514 0 0
AC Immune SA Shares H00263105 1,777 171,813 SH   SOLE   171,813 0 0
Acadia Healthcare Company, Inc. Common 00404A109 10,673 272,400 SH   SOLE   272,400 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 2,105 93,689 SH   SOLE   93,689 0 0
Acceleron Pharma Inc. Common 00434H108 10,678 273,098 SH   SOLE   273,098 0 0
Achillion Pharmaceuticals, Inc. Common 00448Q201 2,285 616,000 SH   SOLE   616,000 0 0
Adamas Pharmaceuticals, Inc. Common 00548A106 399 16,699 SH   SOLE   16,699 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 9,607 855,468 SH   SOLE   855,468 0 0
Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 10,010 13,000,000 PRN   SOLE   13,000,000 0 0
Aetna Inc. Common 00817Y108 8,039 47,566 SH   SOLE   47,566 0 0
Affimed N.V. Common N01045108 3,340 1,805,324 SH   SOLE   1,805,324 0 0
Agios Pharmaceuticals, Inc. Common 00847X104 230 2,810 SH   SOLE   2,810 0 0
Akebia Therapeutics, Inc. Common 00972D105 1,266 132,849 SH   SOLE   132,849 0 0
Albireo Pharma, Inc. Common 01345P106 4,071 125,000 SH   SOLE   125,000 0 0
Alder Biopharmaceuticals, Inc. Common 014339105 3,555 279,950 SH   SOLE   279,950 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 55,616 498,975 SH   SOLE   498,975 0 0
Alkermes plc Shares G01767105 12,182 210,182 SH   SOLE   210,182 0 0
Allergan plc Shares G0177J108 41,877 248,836 SH   SOLE   248,836 0 0
Alliqua BioMedical, Inc. Common 019621309 318 165,000 SH   SOLE   165,000 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 15,528 130,376 SH   SOLE   130,376 0 0
Amarin Corporation plc Sponsored ADR 023111206 1,439 478,149 SH   SOLE   478,149 0 0
AmerisourceBergen Corporation Common 03073E105 7,992 92,707 SH   SOLE   92,707 0 0
Amgen Inc. Common 031162100 119,436 700,588 SH   SOLE   700,588 0 0
Amicus Therapeutics, Inc. Common 03152W109 13,165 875,304 SH   SOLE   875,304 0 0
Anthem, Inc. Common 036752103 20,099 91,482 SH   SOLE   91,482 0 0
ARCA biopharma, Inc. Common 00211Y407 405 811,227 SH   SOLE   811,227 0 0
Ardelyx, Inc. Common 039697107 3,229 639,370 SH   SOLE   639,370 0 0
Arena Pharmaceuticals, Inc. Common 040047607 665 16,827 SH   SOLE   16,827 0 0
argenx SE Sponsored ADR 04016X101 3,132 38,931 SH   SOLE   38,931 0 0
Array BioPharma Inc. Common 04269X105 2,547 156,056 SH   SOLE   156,056 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 406 6,214 SH   SOLE   6,214 0 0
AstraZeneca PLC Sponsored ADR 046353108 15,478 442,600 SH   SOLE   442,600 0 0
Avadel Pharmaceuticals plc Sponsored ADR 05337M104 5,938 814,588 SH   SOLE   814,588 0 0
AveXis, Inc. Common 05366U100 8,693 70,347 SH   SOLE   70,347 0 0
Baxter International Inc. Sponsored ADR 071813109 2,599 39,965 SH   SOLE   39,965 0 0
Becton, Dickinson and Company Common 075887109 3,739 17,254 SH   SOLE   17,254 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 8,315 49,496 SH   SOLE   49,496 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 394 60,000 SH   SOLE   60,000 0 0
Biogen Inc. Common 09062X103 103,696 378,703 SH   SOLE   378,703 0 0
Biohaven Pharmaceutical Holding Company Ltd. Common G11196105 4,185 162,477 SH   SOLE   162,477 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 22,787 281,076 SH   SOLE   281,076 0 0
bluebird Bio, Inc. Common 09609G100 11,322 66,308 SH   SOLE   66,308 0 0
Blueprint Medicines Corporation Common 09627Y109 6,806 74,221 SH   SOLE   74,221 0 0
Boston Scientific Corporation Common 101137107 12,501 457,585 SH   SOLE   457,585 0 0
Bristol-Myers Squibb Company Common 110122108 33,252 525,722 SH   SOLE   525,722 0 0
Cardinal Health, Inc. Common 14149Y108 395 6,300 SH   SOLE   6,300 0 0
Celgene Corporation Common 151020104 120,687 1,352,842 SH   SOLE   1,352,842 0 0
Celldex Therapeutics, Inc. Common 15117B103 247 105,800 SH   SOLE   105,800 0 0
Cellectis S.A. Sponsored ADR 15117K103 8,925 283,250 SH   SOLE   283,250 0 0
Centene Corporation Common 15135B101 24,597 230,158 SH   SOLE   230,158 0 0
Charles River Laboratories International, Inc. Common 159864107 2,420 22,670 SH   SOLE   22,670 0 0
Cidara Therapeutics, Inc. Common 171757107 635 158,784 SH   SOLE   158,784 0 0
Cigna Corporation Common 125509109 9,488 56,563 SH   SOLE   56,563 0 0
Clovis Oncology, Inc. Common 189464100 3,981 75,400 SH   SOLE   75,400 0 0
Coherus BioSciences, Inc. Common 19249H103 2,000 181,023 SH   SOLE   181,023 0 0
Community Health Systems, Inc. Common 203668108 808 203,935 SH   SOLE   203,935 0 0
CRISPR Therapeutics AG Common H17182108 6,454 141,191 SH   SOLE   141,191 0 0
CVS Health Corporation Common 126650100 22,801 366,521 SH   SOLE   366,521 0 0
Cymabay Therapeutics, Inc. Common 23257D103 2,208 169,962 SH   SOLE   169,962 0 0
Cytokinetics, Incorporated Common 23282W605 992 137,797 SH   SOLE   137,797 0 0
CytomX Therapeutics, Inc. Common 23284F105 7,541 265,045 SH   SOLE   265,045 0 0
Danaher Corporation Common 235851102 7,328 74,847 SH   SOLE   74,847 0 0
Dermira, Inc. Common 24983L104 1,871 234,200 SH   SOLE   234,200 0 0
Diplomat Pharmacy, Inc. Common 25456K101 8,846 439,001 SH   SOLE   439,001 0 0
Editas Medicine, Inc. Common 28106W103 4,568 137,801 SH   SOLE   137,801 0 0
Edwards Lifesciences Corporation Common 28176E108 9,247 66,275 SH   SOLE   66,275 0 0
Egalet Corporation Note 5.50% 4/1/20 28226BAB0 2,586 7,000,000 PRN   SOLE   7,000,000 0 0
Eiger BioPharmaceuticals, Inc. Common 28249U105 452 45,854 SH   SOLE   45,854 0 0
Eli Lilly and Company Common 532457108 37,669 486,865 SH   SOLE   486,865 0 0
Endo International plc Shares G30401106 5,432 914,548 SH   SOLE   914,548 0 0
Epizyme, Inc. Common 29428V104 8,615 485,325 SH   SOLE   485,325 0 0
Esperion Therapeutics, Inc. Common 29664W105 13,691 189,287 SH   SOLE   189,287 0 0
Evolent Health, Inc. Class A 30050B101 1,746 122,500 SH   SOLE   122,500 0 0
Exelixis, Inc. Common 30161Q104 8,612 388,822 SH   SOLE   388,822 0 0
Express Scripts Holding Company Common 30219G108 7,357 106,500 SH   SOLE   106,500 0 0
FibroGen, Inc. Common 31572Q808 4,819 104,307 SH   SOLE   104,307 0 0
Foamix Pharmaceuticals Ltd Shares M46135105 4,773 930,398 SH   SOLE   930,398 0 0
Foundation Medicine, Inc. Common 350465100 500 6,353 SH   SOLE   6,353 0 0
Galapagos NV Sponsored ADR 36315X101 9,541 95,635 SH   SOLE   95,635 0 0
Gilead Sciences, Inc. Common 375558103 155,582 2,063,699 SH   SOLE   2,063,699 0 0
Glaukos Corporation Common 377322102 1,698 55,079 SH   SOLE   55,079 0 0
GlaxoSmithKline plc Shares 37733W105 15,423 394,749 SH   SOLE   394,749 0 0
Global Blood Therapeutics, Inc. Common 37890U108 6,276 129,948 SH   SOLE   129,948 0 0
Global Medical REIT Inc. Common 37954A204 510 73,400 SH   SOLE   73,400 0 0
GW Pharmaceuticals plc ADS 36197T103 12,482 110,784 SH   SOLE   110,784 0 0
HCA Healthcare, Inc. Common 40412C101 8,912 91,881 SH   SOLE   91,881 0 0
HCP, Inc. Common 40414L109 1,057 45,500 SH   SOLE   45,500 0 0
Healthcare Realty Trust Incorporated Common 421946104 1,884 68,000 SH   SOLE   68,000 0 0
Healthcare Trust of America, Inc. Class A 42225P501 1,217 46,000 SH   SOLE   46,000 0 0
Henry Schein, Inc. Common 806407102 2,110 31,400 SH   SOLE   31,400 0 0
Hologic, Inc. Common 436440101 730 19,546 SH   SOLE   19,546 0 0
Horizon Pharma plc Shares G4617B105 2,313 162,900 SH   SOLE   162,900 0 0
Humana Inc. Common 444859102 31,919 118,733 SH   SOLE   118,733 0 0
IDEXX Laboratories, Inc. Common 45168D104 29,297 153,076 SH   SOLE   153,076 0 0
Illumina, Inc. Common 452327109 69,718 294,892 SH   SOLE   294,892 0 0
Incyte Corporation Common 45337C102 53,785 645,442 SH   SOLE   645,442 0 0
Innoviva, Inc. Common 45781M101 2,694 161,603 SH   SOLE   161,603 0 0
Intellia Therapeutics, Inc. Common 45826J105 3,530 167,381 SH   SOLE   167,381 0 0
Intuitive Surgical, Inc. Common 46120E602 5,870 14,218 SH   SOLE   14,218 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 7,303 165,677 SH   SOLE   165,677 0 0
Jazz Pharmaceuticals plc Shares G50871105 18,494 122,482 SH   SOLE   122,482 0 0
Johnson & Johnson Common 478160104 114,448 893,082 SH   SOLE   893,082 0 0
Jounce Therapeutics, Inc. Common 481116101 226 10,127 SH   SOLE   10,127 0 0
Koninklijke Philips N.V. NY Registry Shares 500472303 2,886 75,335 SH   SOLE   75,335 0 0
Lexicon Pharmaceuticals, Inc. Common 528872302 1,980 231,054 SH   SOLE   231,054 0 0
LTC Properties, Inc. Common 502175102 7,968 209,673 SH   SOLE   209,673 0 0
Mallinckrodt plc Shares G5785G107 896 61,900 SH   SOLE   61,900 0 0
Masimo Corporation Common 574795100 3,665 41,666 SH   SOLE   41,666 0 0
McKesson Corporation Common 58155Q103 13,918 98,797 SH   SOLE   98,797 0 0
Medical Properties Trust, Inc. Common 58463J304 11,162 858,586 SH   SOLE   858,586 0 0
The Medicines Company Common 584688105 9,170 278,391 SH   SOLE   278,391 0 0
Medtronic plc Shares G5960L103 41,892 522,211 SH   SOLE   522,211 0 0
Merck & Co., Inc. Common 58933Y105 69,941 1,284,022 SH   SOLE   1,284,022 0 0
Merus B.V. Common N5749R100 8,879 479,150 SH   SOLE   479,150 0 0
Molecular Templates, Inc. Common 608550109 423 52,891 SH   SOLE   52,891 0 0
Mylan N.V. Shares N59465109 71,099 1,726,967 SH   SOLE   1,726,967 0 0
Myovant Sciences Ltd. Common G637AM102 3,201 150,471 SH   SOLE   150,471 0 0
NanoString Technologies, Inc. Common 63009R109 558 74,250 SH   SOLE   74,250 0 0
Natera, Inc. Common 632307104 962 103,731 SH   SOLE   103,731 0 0
Natus Medical Incorporated Common 639050103 381 11,335 SH   SOLE   11,335 0 0
Nektar Therapeutics Common 640268108 13,231 124,517 SH   SOLE   124,517 0 0
Neurocrine Biosciences, Inc. Common 64125C109 23,172 279,419 SH   SOLE   279,419 0 0
Nevro Corp. Common 64157F103 4,593 52,990 SH   SOLE   52,990 0 0
New Senior Investment Group Inc. Common 648691103 7,230 883,919 SH   SOLE   883,919 0 0
NewLink Genetics Corporation Common 651511107 1,486 205,026 SH   SOLE   205,026 0 0
Novartis AG Sponsored ADR 66987V109 28,380 351,020 SH   SOLE   351,020 0 0
Novavax, Inc. Common 670002104 1,199 571,000 SH   SOLE   571,000 0 0
Novo Nordisk A/S Sponsored ADR 670100205 6,693 135,900 SH   SOLE   135,900 0 0
NuCana plc Sponsored ADR 67022C106 464 24,536 SH   SOLE   24,536 0 0
Omega Healthcare Investors, Inc. Common 681936100 15,677 579,785 SH   SOLE   579,785 0 0
Ovid Therapeutics Inc. Common 690469101 3,788 535,824 SH   SOLE   535,824 0 0
Perrigo Company plc Shares G97822103 3,109 37,300 SH   SOLE   37,300 0 0
Pfizer Inc. Common 717081103 72,823 2,051,943 SH   SOLE   2,051,943 0 0
Physicians Realty Trust Common 71943U104 4,131 265,336 SH   SOLE   265,336 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 14,236 2,087,380 SH   SOLE   2,087,380 0 0
Portola Pharmaceuticals, Inc. Common 737010108 2,939 89,978 SH   SOLE   89,978 0 0
PRA Health Sciences, Inc. Common 69354M108 2,693 32,460 SH   SOLE   32,460 0 0
Protagonist Therapeutics, Inc. Common 74366E102 1,882 219,042 SH   SOLE   219,042 0 0
PTC Therapeutics, Inc. Common 69366J200 658 24,299 SH   SOLE   24,299 0 0
Puma Biotechnology, Inc. Common 74587V107 3,810 55,985 SH   SOLE   55,985 0 0
Quorum Health Corporation Common 74909E106 194 23,725 SH   SOLE   23,725 0 0
Quotient Limited Shares G73268107 2,084 442,461 SH   SOLE   442,461 0 0
Ra Pharmaceuticals, Inc. Common 74933V108 1,798 338,565 SH   SOLE   338,565 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 48,059 139,560 SH   SOLE   139,560 0 0
ResMed Inc. Common 761152107 3,330 33,819 SH   SOLE   33,819 0 0
Revance Therapeutics, Inc. Common 761330109 1,335 43,329 SH   SOLE   43,329 0 0
The RMR Group Inc. Class A 74967R106 520 7,441 SH   SOLE   7,441 0 0
Sabra Health Care REIT, Inc. Common 78573L106 12,789 724,606 SH   SOLE   724,606 0 0
Sage Therapeutics, Inc. Common 78667J108 20,077 124,650 SH   SOLE   124,650 0 0
Sanofi Sponsored ADR 80105N105 7,210 179,900 SH   SOLE   179,900 0 0
Sarepta Therapeutics, Inc. Common 803607100 28,044 378,516 SH   SOLE   378,516 0 0
Seattle Genetics, Inc. Common 812578102 18,136 346,499 SH   SOLE   346,499 0 0
Senior Housing Properties Trust Shares 81721M109 10,125 646,554 SH   SOLE   646,554 0 0
Shire plc Sponsored ADR 82481R106 17,274 115,629 SH   SOLE   115,629 0 0
Smith & Nephew plc Sponsored ADR 83175M205 1,684 44,148 SH   SOLE   44,148 0 0
Spark Therapeutics, Inc. Common 84652J103 1,468 22,046 SH   SOLE   22,046 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 21,973 250,460 SH   SOLE   250,460 0 0
STERIS plc Shares G84720104 1,551 16,612 SH   SOLE   16,612 0 0
Stryker Corporation Common 863667101 10,340 64,258 SH   SOLE   64,258 0 0
Syndax Pharmaceuticals, Inc. Common 87164F105 2,846 200,000 SH   SOLE   200,000 0 0
Teleflex Incorporated Common 879369106 633 2,482 SH   SOLE   2,482 0 0
Teligent, Inc. Common 87960W104 1,853 551,429 SH   SOLE   551,429 0 0
Tenet Healthcare Corporation Common 88033G407 3,989 164,500 SH   SOLE   164,500 0 0
TESARO, Inc. Common 881569107 3,291 57,595 SH   SOLE   57,595 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N105 2,638 859,322 SH   SOLE   859,322 0 0
Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 18,512 1,083,223 SH   SOLE   1,083,223 0 0
TherapeuticsMD, Inc. Common 88338N107 2,283 468,769 SH   SOLE   468,769 0 0
Theravance Biopharma, Inc. Common G8807B106 196 8,083 SH   SOLE   8,083 0 0
Thermo Fisher Scientific Inc. Common 883556102 30,526 147,855 SH   SOLE   147,855 0 0
Trillium Therapeutics Inc. Common 89620X506 3,372 468,399 SH   SOLE   468,399 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 7,575 148,558 SH   SOLE   148,558 0 0
uniQure N.V. Shares N90064101 4,694 199,750 SH   SOLE   199,750 0 0
United Therapeutics Corporation Common 91307C102 4,636 41,261 SH   SOLE   41,261 0 0
Unitedhealth Group Incorporated Common 91324P102 75,396 352,317 SH   SOLE   352,317 0 0
Valeant Pharmaceuticals International, Inc. Common 91911K102 3,057 192,000 SH   SOLE   192,000 0 0
Varian Medical Systems, Inc. Common 92220P105 621 5,065 SH   SOLE   5,065 0 0
Ventas, Inc. Common 92276F100 4,358 87,996 SH   SOLE   87,996 0 0
Verona Pharma plc Sponsored ADR 925050106 5,500 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 100,083 614,084 SH   SOLE   614,084 0 0
Welltower Inc. 6.50% Preferred Perpetual 95040Q203 11,128 200,000 SH   SOLE   200,000 0 0
Welltower Inc. Common 95040Q104 1,165 21,400 SH   SOLE   21,400 0 0
Wright Medical Group N.V. Ordinary Shares N96617118 5,293 266,781 SH   SOLE   266,781 0 0
Xencor, Inc. Common 98401F105 600 20,000 SH   SOLE   20,000 0 0
Xenon Pharmaceuticals Inc. Common 98420N105 1,372 280,000 SH   SOLE   280,000 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 8,950 82,080 SH   SOLE   82,080 0 0