Chief Compliance Officer

0001104659-18-032830.txt : 20180514 0001104659-18-032830.hdr.sgml : 20180514 20180514122025 ACCESSION NUMBER: 0001104659-18-032830 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20180331 FILED AS OF DATE: 20180514 DATE AS OF CHANGE: 20180514 EFFECTIVENESS DATE: 20180514 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Tekla Capital Management LLC CENTRAL INDEX KEY: 0001300336 IRS NUMBER: 010628853 STATE OF INCORPORATION: DE FISCAL YEAR END: 0930 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10950 FILM NUMBER: 18829469 BUSINESS ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 BUSINESS PHONE: 617 772-8500 MAIL ADDRESS: STREET 1: 100 FEDERAL STREET STREET 2: 19TH FLOOR CITY: BOSTON STATE: MA ZIP: 02110 FORMER COMPANY: FORMER CONFORMED NAME: Hambrecht & Quist Capital Management LLC DATE OF NAME CHANGE: 20040811 13F-HR 1 primary_doc.xml 13F-HR LIVE 0001300336 XXXXXXXX 03-31-2018 03-31-2018 false Tekla Capital Management LLC

100 FEDERAL STREET 19TH FLOOR BOSTON MA 02110

13F HOLDINGS REPORT 028-10950 N Laura Woodward Chief Compliance Officer 617-772-8500 /s/ Laura Woodward Boston MA 05-14-2018 0 187 2571230 false INFORMATION TABLE 2 a18-9091_1informationtable.xml INFORMATION TABLE Abbott Laboratories Common 002824100 47853 798619 SH SOLE 798619 0 0 AbbVie Inc. Common 00287Y109 42662 450738 SH SOLE 450738 0 0 ABIOMED, Inc. Common 003654100 1896 6514 SH SOLE 6514 0 0 AC Immune SA Shares H00263105 1777 171813 SH SOLE 171813 0 0 Acadia Healthcare Company, Inc. Common 00404A109 10673 272400 SH SOLE 272400 0 0 ACADIA Pharmaceuticals Inc. Common 004225108 2105 93689 SH SOLE 93689 0 0 Acceleron Pharma Inc. Common 00434H108 10678 273098 SH SOLE 273098 0 0 Achillion Pharmaceuticals, Inc. Common 00448Q201 2285 616000 SH SOLE 616000 0 0 Adamas Pharmaceuticals, Inc. Common 00548A106 399 16699 SH SOLE 16699 0 0 Adaptimmune Therapeutics plc Sponsored ADR 00653A107 9607 855468 SH SOLE 855468 0 0 Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 10010 13000000 PRN SOLE 13000000 0 0 Aetna Inc. Common 00817Y108 8039 47566 SH SOLE 47566 0 0 Affimed N.V. Common N01045108 3340 1805324 SH SOLE 1805324 0 0 Agios Pharmaceuticals, Inc. Common 00847X104 230 2810 SH SOLE 2810 0 0 Akebia Therapeutics, Inc. Common 00972D105 1266 132849 SH SOLE 132849 0 0 Albireo Pharma, Inc. Common 01345P106 4071 125000 SH SOLE 125000 0 0 Alder Biopharmaceuticals, Inc. Common 014339105 3555 279950 SH SOLE 279950 0 0 Alexion Pharmaceuticals, Inc. Common 015351109 55616 498975 SH SOLE 498975 0 0 Alkermes plc Shares G01767105 12182 210182 SH SOLE 210182 0 0 Allergan plc Shares G0177J108 41877 248836 SH SOLE 248836 0 0 Alliqua BioMedical, Inc. Common 019621309 318 165000 SH SOLE 165000 0 0 Alnylam Pharmaceuticals, Inc. Common 02043Q107 15528 130376 SH SOLE 130376 0 0 Amarin Corporation plc Sponsored ADR 023111206 1439 478149 SH SOLE 478149 0 0 AmerisourceBergen Corporation Common 03073E105 7992 92707 SH SOLE 92707 0 0 Amgen Inc. Common 031162100 119436 700588 SH SOLE 700588 0 0 Amicus Therapeutics, Inc. Common 03152W109 13165 875304 SH SOLE 875304 0 0 Anthem, Inc. Common 036752103 20099 91482 SH SOLE 91482 0 0 ARCA biopharma, Inc. Common 00211Y407 405 811227 SH SOLE 811227 0 0 Ardelyx, Inc. Common 039697107 3229 639370 SH SOLE 639370 0 0 Arena Pharmaceuticals, Inc. Common 040047607 665 16827 SH SOLE 16827 0 0 argenx SE Sponsored ADR 04016X101 3132 38931 SH SOLE 38931 0 0 Array BioPharma Inc. Common 04269X105 2547 156056 SH SOLE 156056 0 0 Ascendis Pharma A/S Sponsored ADR 04351P101 406 6214 SH SOLE 6214 0 0 AstraZeneca PLC Sponsored ADR 046353108 15478 442600 SH SOLE 442600 0 0 Avadel Pharmaceuticals plc Sponsored ADR 05337M104 5938 814588 SH SOLE 814588 0 0 AveXis, Inc. Common 05366U100 8693 70347 SH SOLE 70347 0 0 Baxter International Inc. Sponsored ADR 071813109 2599 39965 SH SOLE 39965 0 0 Becton, Dickinson and Company Common 075887109 3739 17254 SH SOLE 17254 0 0 BeiGene, Ltd. Sponsored ADR 07725L102 8315 49496 SH SOLE 49496 0 0 Bellicum Pharmaceuticals, Inc. Common 079481107 394 60000 SH SOLE 60000 0 0 Biogen Inc. Common 09062X103 103696 378703 SH SOLE 378703 0 0 Biohaven Pharmaceutical Holding Company Ltd. Common G11196105 4185 162477 SH SOLE 162477 0 0 BioMarin Pharmaceutical Inc. Common 09061G101 22787 281076 SH SOLE 281076 0 0 bluebird Bio, Inc. Common 09609G100 11322 66308 SH SOLE 66308 0 0 Blueprint Medicines Corporation Common 09627Y109 6806 74221 SH SOLE 74221 0 0 Boston Scientific Corporation Common 101137107 12501 457585 SH SOLE 457585 0 0 Bristol-Myers Squibb Company Common 110122108 33252 525722 SH SOLE 525722 0 0 Cardinal Health, Inc. Common 14149Y108 395 6300 SH SOLE 6300 0 0 Celgene Corporation Common 151020104 120687 1352842 SH SOLE 1352842 0 0 Celldex Therapeutics, Inc. Common 15117B103 247 105800 SH SOLE 105800 0 0 Cellectis S.A. Sponsored ADR 15117K103 8925 283250 SH SOLE 283250 0 0 Centene Corporation Common 15135B101 24597 230158 SH SOLE 230158 0 0 Charles River Laboratories International, Inc. Common 159864107 2420 22670 SH SOLE 22670 0 0 Cidara Therapeutics, Inc. Common 171757107 635 158784 SH SOLE 158784 0 0 Cigna Corporation Common 125509109 9488 56563 SH SOLE 56563 0 0 Clovis Oncology, Inc. Common 189464100 3981 75400 SH SOLE 75400 0 0 Coherus BioSciences, Inc. Common 19249H103 2000 181023 SH SOLE 181023 0 0 Community Health Systems, Inc. Common 203668108 808 203935 SH SOLE 203935 0 0 CRISPR Therapeutics AG Common H17182108 6454 141191 SH SOLE 141191 0 0 CVS Health Corporation Common 126650100 22801 366521 SH SOLE 366521 0 0 Cymabay Therapeutics, Inc. Common 23257D103 2208 169962 SH SOLE 169962 0 0 Cytokinetics, Incorporated Common 23282W605 992 137797 SH SOLE 137797 0 0 CytomX Therapeutics, Inc. Common 23284F105 7541 265045 SH SOLE 265045 0 0 Danaher Corporation Common 235851102 7328 74847 SH SOLE 74847 0 0 Dermira, Inc. Common 24983L104 1871 234200 SH SOLE 234200 0 0 Diplomat Pharmacy, Inc. Common 25456K101 8846 439001 SH SOLE 439001 0 0 Editas Medicine, Inc. Common 28106W103 4568 137801 SH SOLE 137801 0 0 Edwards Lifesciences Corporation Common 28176E108 9247 66275 SH SOLE 66275 0 0 Egalet Corporation Note 5.50% 4/1/20 28226BAB0 2586 7000000 PRN SOLE 7000000 0 0 Eiger BioPharmaceuticals, Inc. Common 28249U105 452 45854 SH SOLE 45854 0 0 Eli Lilly and Company Common 532457108 37669 486865 SH SOLE 486865 0 0 Endo International plc Shares G30401106 5432 914548 SH SOLE 914548 0 0 Epizyme, Inc. Common 29428V104 8615 485325 SH SOLE 485325 0 0 Esperion Therapeutics, Inc. Common 29664W105 13691 189287 SH SOLE 189287 0 0 Evolent Health, Inc. Class A 30050B101 1746 122500 SH SOLE 122500 0 0 Exelixis, Inc. Common 30161Q104 8612 388822 SH SOLE 388822 0 0 Express Scripts Holding Company Common 30219G108 7357 106500 SH SOLE 106500 0 0 FibroGen, Inc. Common 31572Q808 4819 104307 SH SOLE 104307 0 0 Foamix Pharmaceuticals Ltd Shares M46135105 4773 930398 SH SOLE 930398 0 0 Foundation Medicine, Inc. Common 350465100 500 6353 SH SOLE 6353 0 0 Galapagos NV Sponsored ADR 36315X101 9541 95635 SH SOLE 95635 0 0 Gilead Sciences, Inc. Common 375558103 155582 2063699 SH SOLE 2063699 0 0 Glaukos Corporation Common 377322102 1698 55079 SH SOLE 55079 0 0 GlaxoSmithKline plc Shares 37733W105 15423 394749 SH SOLE 394749 0 0 Global Blood Therapeutics, Inc. Common 37890U108 6276 129948 SH SOLE 129948 0 0 Global Medical REIT Inc. Common 37954A204 510 73400 SH SOLE 73400 0 0 GW Pharmaceuticals plc ADS 36197T103 12482 110784 SH SOLE 110784 0 0 HCA Healthcare, Inc. Common 40412C101 8912 91881 SH SOLE 91881 0 0 HCP, Inc. Common 40414L109 1057 45500 SH SOLE 45500 0 0 Healthcare Realty Trust Incorporated Common 421946104 1884 68000 SH SOLE 68000 0 0 Healthcare Trust of America, Inc. Class A 42225P501 1217 46000 SH SOLE 46000 0 0 Henry Schein, Inc. Common 806407102 2110 31400 SH SOLE 31400 0 0 Hologic, Inc. Common 436440101 730 19546 SH SOLE 19546 0 0 Horizon Pharma plc Shares G4617B105 2313 162900 SH SOLE 162900 0 0 Humana Inc. Common 444859102 31919 118733 SH SOLE 118733 0 0 IDEXX Laboratories, Inc. Common 45168D104 29297 153076 SH SOLE 153076 0 0 Illumina, Inc. Common 452327109 69718 294892 SH SOLE 294892 0 0 Incyte Corporation Common 45337C102 53785 645442 SH SOLE 645442 0 0 Innoviva, Inc. Common 45781M101 2694 161603 SH SOLE 161603 0 0 Intellia Therapeutics, Inc. Common 45826J105 3530 167381 SH SOLE 167381 0 0 Intuitive Surgical, Inc. Common 46120E602 5870 14218 SH SOLE 14218 0 0 Ionis Pharmaceuticals, Inc. Common 462222100 7303 165677 SH SOLE 165677 0 0 Jazz Pharmaceuticals plc Shares G50871105 18494 122482 SH SOLE 122482 0 0 Johnson & Johnson Common 478160104 114448 893082 SH SOLE 893082 0 0 Jounce Therapeutics, Inc. Common 481116101 226 10127 SH SOLE 10127 0 0 Koninklijke Philips N.V. NY Registry Shares 500472303 2886 75335 SH SOLE 75335 0 0 Lexicon Pharmaceuticals, Inc. Common 528872302 1980 231054 SH SOLE 231054 0 0 LTC Properties, Inc. Common 502175102 7968 209673 SH SOLE 209673 0 0 Mallinckrodt plc Shares G5785G107 896 61900 SH SOLE 61900 0 0 Masimo Corporation Common 574795100 3665 41666 SH SOLE 41666 0 0 McKesson Corporation Common 58155Q103 13918 98797 SH SOLE 98797 0 0 Medical Properties Trust, Inc. Common 58463J304 11162 858586 SH SOLE 858586 0 0 The Medicines Company Common 584688105 9170 278391 SH SOLE 278391 0 0 Medtronic plc Shares G5960L103 41892 522211 SH SOLE 522211 0 0 Merck & Co., Inc. Common 58933Y105 69941 1284022 SH SOLE 1284022 0 0 Merus B.V. Common N5749R100 8879 479150 SH SOLE 479150 0 0 Molecular Templates, Inc. Common 608550109 423 52891 SH SOLE 52891 0 0 Mylan N.V. Shares N59465109 71099 1726967 SH SOLE 1726967 0 0 Myovant Sciences Ltd. Common G637AM102 3201 150471 SH SOLE 150471 0 0 NanoString Technologies, Inc. Common 63009R109 558 74250 SH SOLE 74250 0 0 Natera, Inc. Common 632307104 962 103731 SH SOLE 103731 0 0 Natus Medical Incorporated Common 639050103 381 11335 SH SOLE 11335 0 0 Nektar Therapeutics Common 640268108 13231 124517 SH SOLE 124517 0 0 Neurocrine Biosciences, Inc. Common 64125C109 23172 279419 SH SOLE 279419 0 0 Nevro Corp. Common 64157F103 4593 52990 SH SOLE 52990 0 0 New Senior Investment Group Inc. Common 648691103 7230 883919 SH SOLE 883919 0 0 NewLink Genetics Corporation Common 651511107 1486 205026 SH SOLE 205026 0 0 Novartis AG Sponsored ADR 66987V109 28380 351020 SH SOLE 351020 0 0 Novavax, Inc. Common 670002104 1199 571000 SH SOLE 571000 0 0 Novo Nordisk A/S Sponsored ADR 670100205 6693 135900 SH SOLE 135900 0 0 NuCana plc Sponsored ADR 67022C106 464 24536 SH SOLE 24536 0 0 Omega Healthcare Investors, Inc. Common 681936100 15677 579785 SH SOLE 579785 0 0 Ovid Therapeutics Inc. Common 690469101 3788 535824 SH SOLE 535824 0 0 Perrigo Company plc Shares G97822103 3109 37300 SH SOLE 37300 0 0 Pfizer Inc. Common 717081103 72823 2051943 SH SOLE 2051943 0 0 Physicians Realty Trust Common 71943U104 4131 265336 SH SOLE 265336 0 0 Pieris Pharmaceuticals, Inc. Common 720795103 14236 2087380 SH SOLE 2087380 0 0 Portola Pharmaceuticals, Inc. Common 737010108 2939 89978 SH SOLE 89978 0 0 PRA Health Sciences, Inc. Common 69354M108 2693 32460 SH SOLE 32460 0 0 Protagonist Therapeutics, Inc. Common 74366E102 1882 219042 SH SOLE 219042 0 0 PTC Therapeutics, Inc. Common 69366J200 658 24299 SH SOLE 24299 0 0 Puma Biotechnology, Inc. Common 74587V107 3810 55985 SH SOLE 55985 0 0 Quorum Health Corporation Common 74909E106 194 23725 SH SOLE 23725 0 0 Quotient Limited Shares G73268107 2084 442461 SH SOLE 442461 0 0 Ra Pharmaceuticals, Inc. Common 74933V108 1798 338565 SH SOLE 338565 0 0 Regeneron Pharmaceuticals, Inc. Common 75886F107 48059 139560 SH SOLE 139560 0 0 ResMed Inc. Common 761152107 3330 33819 SH SOLE 33819 0 0 Revance Therapeutics, Inc. Common 761330109 1335 43329 SH SOLE 43329 0 0 The RMR Group Inc. Class A 74967R106 520 7441 SH SOLE 7441 0 0 Sabra Health Care REIT, Inc. Common 78573L106 12789 724606 SH SOLE 724606 0 0 Sage Therapeutics, Inc. Common 78667J108 20077 124650 SH SOLE 124650 0 0 Sanofi Sponsored ADR 80105N105 7210 179900 SH SOLE 179900 0 0 Sarepta Therapeutics, Inc. Common 803607100 28044 378516 SH SOLE 378516 0 0 Seattle Genetics, Inc. Common 812578102 18136 346499 SH SOLE 346499 0 0 Senior Housing Properties Trust Shares 81721M109 10125 646554 SH SOLE 646554 0 0 Shire plc Sponsored ADR 82481R106 17274 115629 SH SOLE 115629 0 0 Smith & Nephew plc Sponsored ADR 83175M205 1684 44148 SH SOLE 44148 0 0 Spark Therapeutics, Inc. Common 84652J103 1468 22046 SH SOLE 22046 0 0 SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 21973 250460 SH SOLE 250460 0 0 STERIS plc Shares G84720104 1551 16612 SH SOLE 16612 0 0 Stryker Corporation Common 863667101 10340 64258 SH SOLE 64258 0 0 Syndax Pharmaceuticals, Inc. Common 87164F105 2846 200000 SH SOLE 200000 0 0 Teleflex Incorporated Common 879369106 633 2482 SH SOLE 2482 0 0 Teligent, Inc. Common 87960W104 1853 551429 SH SOLE 551429 0 0 Tenet Healthcare Corporation Common 88033G407 3989 164500 SH SOLE 164500 0 0 TESARO, Inc. Common 881569107 3291 57595 SH SOLE 57595 0 0 Tetraphase Pharmaceuticals, Inc. Common 88165N105 2638 859322 SH SOLE 859322 0 0 Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 18512 1083223 SH SOLE 1083223 0 0 TherapeuticsMD, Inc. Common 88338N107 2283 468769 SH SOLE 468769 0 0 Theravance Biopharma, Inc. Common G8807B106 196 8083 SH SOLE 8083 0 0 Thermo Fisher Scientific Inc. Common 883556102 30526 147855 SH SOLE 147855 0 0 Trillium Therapeutics Inc. Common 89620X506 3372 468399 SH SOLE 468399 0 0 Ultragenyx Pharmaceutical Inc. Common 90400D108 7575 148558 SH SOLE 148558 0 0 uniQure N.V. Shares N90064101 4694 199750 SH SOLE 199750 0 0 United Therapeutics Corporation Common 91307C102 4636 41261 SH SOLE 41261 0 0 Unitedhealth Group Incorporated Common 91324P102 75396 352317 SH SOLE 352317 0 0 Valeant Pharmaceuticals International, Inc. Common 91911K102 3057 192000 SH SOLE 192000 0 0 Varian Medical Systems, Inc. Common 92220P105 621 5065 SH SOLE 5065 0 0 Ventas, Inc. Common 92276F100 4358 87996 SH SOLE 87996 0 0 Verona Pharma plc Sponsored ADR 925050106 5500 275000 SH SOLE 275000 0 0 Vertex Pharmaceuticals Incorporated Common 92532F100 100083 614084 SH SOLE 614084 0 0 Welltower Inc. 6.50% Preferred Perpetual 95040Q203 11128 200000 SH SOLE 200000 0 0 Welltower Inc. Common 95040Q104 1165 21400 SH SOLE 21400 0 0 Wright Medical Group N.V. Ordinary Shares N96617118 5293 266781 SH SOLE 266781 0 0 Xencor, Inc. Common 98401F105 600 20000 SH SOLE 20000 0 0 Xenon Pharmaceuticals Inc. Common 98420N105 1372 280000 SH SOLE 280000 0 0 Zimmer Biomet Holdings, Inc. Common 98956P102 8950 82080 SH SOLE 82080 0 0