Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statement on Form S-1 filed pursuant to Rule 462(b) of the Securities Act of 1933 of the reference to our firm under the caption “Experts” and to the incorporation by reference of our report dated March 13, 2015, with respect to the consolidated financial statements and schedule of TearLab Corp. incorporated by reference in the Registration Statement (Form S-1 No. 333-210326) and related Prospectus of TearLab Corp. for the registration of its Class A and B Units.

/s/ Ernst & Young LLP

San Diego, CA

May 3, 2016