POWER OF ATTORNEY

The undersigned, as a Section 16 reporting person of Pacific Biosciences
of California, Inc. (the "Company"), hereby constitutes and appoints
Susan K. Barnes, Brian Dow and Stephen Moore, and each of them, the
undersigned's true and lawful attorney-in-fact to:

1. complete and execute Forms 3, 4 and 5 and other forms and all amendments
thereto as such attorney-in-fact shall in his or her discretion determine to
be required or advisable pursuant to Section 16 of the Securities Exchange Act
of 1934 (as amended) and the rules and regulations promulgated thereunder, or
any successor laws and regulations, as a consequence of the undersigned's ownership,
acquisition or disposition of securities of the Company; and

2. do all acts necessary in order to file such forms with the Securities and
Exchange Commission, any securities exchange or national association, the Company
and such other person or agency as the attorney-in-fact shall deem appropriate.

   The undersigned also hereby constitutes and appoints the responsible attorneys
and paralegals of Wilson Sonsini Goodrich & Rosati P.C., and each of them, the
undersigned's true and lawful attorney-in-fact and agent to complete, execute and
file a Form ID Application Acknowledgement on EDGAR or such other forms as prescribed
by the U.S. Securities and Exchange Commission in order for the undersigned to apply
for and obtain EDGAR filing codes.

   The undersigned hereby ratifies and confirms all that said attorneys-in-fact and
agents shall do or cause to be done by virtue hereof.  The undersigned acknowledges
that the foregoing attorneys-in-fact, in serving in such capacity at the request of
the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's
responsibilities to comply with Section 16 of the Securities Exchange Act of 1934
(as amended).

   This Power of Attorney shall remain in full force and effect until the undersigned
is no longer required to file Forms ID, 3, 4 and 5 with respect to the undersigned's
holdings of and transactions in securities issued by the Company, unless earlier revoked
by the undersigned in a signed writing delivered to the Company and the foregoing
attorneys-in-fact.

   IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of this 19 day of July, 2012.


Signature: /s/ David Botstein
Name:	David Botstein