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Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2017 $ 1,623,432 $ 494 $ 2,540,951 $ (4,205) $ (913,808)
Beginning balance, shares at Dec. 31, 2017   49,406      
Adjustment to beginning accumulated deficit from adoption of accounting standard update | ASU 2014-09 [Member] (29,375)       (29,375)
Vesting of restricted stock units   $ 1 (1)    
Vesting of restricted stock units, shares   74      
Issuance of common stock upon public offering, net of issuance costs 48,701 $ 3 48,698    
Issuance of common stock upon public offering, net of issuance costs, shares   277      
Exercise of stock options 19,730 $ 3 19,727    
Exercise of stock options, shares   301      
Purchase of common stock under ESPP 687   687    
Purchase of common stock under ESPP, shares   9      
Stock-based compensation 22,995   22,995    
Other comprehensive income (loss) (844)     (844)  
Net loss (115,126)       (115,126)
Ending balance at Mar. 31, 2018 1,570,201 $ 501 2,633,057 (5,049) (1,058,308)
Ending balance, shares at Mar. 31, 2018   50,067      
Beginning balance at Dec. 31, 2017 1,623,432 $ 494 2,540,951 (4,205) (913,808)
Beginning balance, shares at Dec. 31, 2017   49,406      
Other comprehensive income (loss) (1,255)        
Net loss (406,602)        
Ending balance at Sep. 30, 2018 2,000,790 $ 547 3,355,491 (5,463) (1,349,785)
Ending balance, shares at Sep. 30, 2018   54,678      
Beginning balance at Mar. 31, 2018 1,570,201 $ 501 2,633,057 (5,049) (1,058,308)
Beginning balance, shares at Mar. 31, 2018   50,067      
Vesting of restricted stock units, shares   33      
Exercise of stock options 5,617 $ 1 5,616    
Exercise of stock options, shares   125      
Stock-based compensation 28,056   28,056    
Other comprehensive income (loss) (345)     (345)  
Net loss (145,996)       (145,996)
Ending balance at Jun. 30, 2018 1,457,534 $ 502 2,666,729 (5,394) (1,204,303)
Ending balance, shares at Jun. 30, 2018   50,225      
Vesting of restricted stock units, shares   25      
Issuance of common stock upon public offering, net of issuance costs 600,667 $ 39 600,628    
Issuance of common stock upon public offering, net of issuance costs, shares   3,892      
Exercise of stock options 2,940 $ 1 2,939    
Exercise of stock options, shares   109      
Purchase of common stock under ESPP 917   917    
Purchase of common stock under ESPP, shares   7      
Stock-based compensation 29,797   29,797    
Issuance of shares to Regeneron 54,484 $ 4 54,480    
Issuance of shares to Regeneron, shares   420      
Other comprehensive income (loss) (66)     (66)  
Net loss (145,480)       (145,480)
Ending balance at Sep. 30, 2018 2,000,790 $ 547 3,355,491 (5,463) (1,349,785)
Ending balance, shares at Sep. 30, 2018   54,678      
Beginning balance at Dec. 31, 2018 $ 1,885,070 $ 547 3,386,958 (3,627) (1,498,808)
Beginning balance, shares at Dec. 31, 2018 54,738 54,738      
Adjustment to beginning accumulated deficit from adoption of accounting standard update | ASU 2016-02 [Member] $ 6,564       6,564
Vesting of restricted stock units   $ 2 (2)    
Vesting of restricted stock units, shares   131      
Exercise of stock options 9,504 $ 2 9,502    
Exercise of stock options, shares   189      
Purchase of common stock under ESPP 1,231   1,231    
Purchase of common stock under ESPP, shares   11      
Stock-based compensation 32,341   32,341    
Other comprehensive income (loss) 1,835     1,835  
Net loss (164,446)       (164,446)
Ending balance at Mar. 31, 2019 1,772,099 $ 551 3,430,030 (1,792) (1,656,690)
Ending balance, shares at Mar. 31, 2019   55,069      
Beginning balance at Dec. 31, 2018 $ 1,885,070 $ 547 3,386,958 (3,627) (1,498,808)
Beginning balance, shares at Dec. 31, 2018 54,738 54,738      
Exercise of stock options, shares 333        
Other comprehensive income (loss) $ 776        
Net loss (566,261)        
Ending balance at Sep. 30, 2019 $ 1,471,710 $ 553 3,532,513 (2,851) (2,058,505)
Ending balance, shares at Sep. 30, 2019 55,320 55,320      
Beginning balance at Mar. 31, 2019 $ 1,772,099 $ 551 3,430,030 (1,792) (1,656,690)
Beginning balance, shares at Mar. 31, 2019   55,069      
Vesting of restricted stock units   $ 1 (1)    
Vesting of restricted stock units, shares   66      
Exercise of stock options 3,973 $ 1 3,972    
Exercise of stock options, shares   93      
Stock-based compensation 55,111   55,111    
Other comprehensive income (loss) 973     973  
Net loss (195,782)       (195,782)
Ending balance at Jun. 30, 2019 1,636,374 $ 553 3,489,112 (819) (1,852,472)
Ending balance, shares at Jun. 30, 2019   55,228      
Vesting of restricted stock units, shares   27      
Exercise of stock options 3,321 $ 1 3,320    
Exercise of stock options, shares   51      
Purchase of common stock under ESPP 1,535   1,535    
Purchase of common stock under ESPP, shares   14      
Stock-based compensation 38,546   38,546    
Other comprehensive income (loss) (2,032)     (2,032)  
Net loss (206,033)       (206,033)
Ending balance at Sep. 30, 2019 $ 1,471,710 $ 553 $ 3,532,513 $ (2,851) $ (2,058,505)
Ending balance, shares at Sep. 30, 2019 55,320 55,320