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Collaborative arrangements - Summary of Revenue Recognized Related to Research and Development Services (Detail) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Revenue $ 8,910 $ 11,528 $ 34,677 $ 35,336
Celgene Corporation [Member] | bb21217 Research and Development Services [Member]        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Revenue $ 721 $ 721 $ 2,163 $ 2,163