Commitments and contingencies (Tables)

12 Months Ended

Dec. 31, 2016

Commitments And Contingencies Disclosure [Abstract]

Future Minimum Commitments

As of December 31, 2016, future minimum commitments under the 60 Binney Street Lease and facility operating leases were as follows (in thousands):

Years ended December 31,	60 Binney Street Lease		150 Second Street Lease		Other Operating Leases		Total Lease Commitments
2017	$	13,102	$	1,359	$	11,963	$	26,424
2018		18,647		-		10,368		29,015
2019		18,974		-		9,841		28,815
2020		19,305		-		9,841		29,146
2021		19,643		-		9,841		29,484
2022 and thereafter		108,875		-		32,725		141,600
Total minimum lease payments	$	198,546	$	1,359	$	84,579	$	284,484

(1) Amounts are subject to increase if the Company does not vacate the leased premise during the second quarter of 2017 as planned.