Income taxes - Reconciliation of Income Tax Provision (Benefit) (Detail)	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Abstract]
Federal income tax expense at statutory rate	21.00%	21.00%	21.00%
State income tax, net of federal benefit	3.90%	3.10%	3.70%
Permanent differences	(0.60%)	(0.60%)	(0.80%)
Stock-based compensation	(3.10%)	(2.40%)	(0.70%)
Research and development credit	4.30%	6.00%	5.40%
Foreign differential	(1.90%)	(4.60%)	(3.70%)
Other	0.00%	(0.30%)	0.80%
Change in valuation allowance	(23.60%)	(22.30%)	(25.60%)
Effective income tax rate (expense) benefit	0.00%	(0.10%)	0.10%

Effective income tax rate reconciliation permanent differences.

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Effective income tax rate reconciliation tax credits research and development.

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to statutory income tax expense (benefit) outside of the country of domicile.

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Percentage of difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to expense for award under share-based payment arrangement. Excludes expense determined to be nondeductible upon grant or after for award under share-based payment arrangement.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to state and local income tax expense (benefit), net of federal tax expense (benefit).

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