Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020
Cash flows from operating activities:
Net loss	$ (664,326)	$ (418,821)
Adjustments to reconcile net loss to net cash used in operating activities:
Change in fair value of contingent consideration	464	(5,591)
Depreciation and amortization	17,335	14,378
Stock-based compensation expense	101,829	123,640
(Gain) loss on equity securities	(28,765)	9,068
Excess inventory reserve	29,712	0
Other non-cash items	13,358	(1,538)
Changes in operating assets and liabilities:
Prepaid expenses and other assets	3,287	(2,534)
Inventory	(19,007)	(9,382)
Operating lease right-of-use assets	22,630	16,345
Accounts payable	2,004	(15,420)
Accrued expenses and other liabilities	54,774	(13,056)
Operating lease liabilities	(24,499)	(14,603)
Deferred revenue	210	8,558
Collaboration research advancement	(4,920)	(6,202)
Net cash used in operating activities	(495,914)	(315,158)
Cash flows from investing activities:
Purchase of property, plant and equipment	(12,944)	(21,098)
Purchases of marketable securities	(421,416)	(964,428)
Proceeds from maturities of marketable securities	802,367	722,487
Proceeds from sales of marketable securities	31,318	29,878
Proceeds from divestiture of business	110,300	0
Purchase of intangible assets	(8,000)	0
Net cash provided by (used in) investing activities	501,625	(233,161)
Cash flows from financing activities:
Proceeds from public offering of common stock, net of issuance costs	0	541,536
Proceeds From Issuance Of Common Stock And Warrants	74,982	0
Proceeds from exercise of stock options and ESPP contributions	5,078	3,747
Net cash provided by financing activities	80,060	545,283
Increase in cash, cash equivalents and restricted cash	85,771	(3,036)
Cash, cash equivalents and restricted cash at beginning of period	373,728	381,709
Cash, cash equivalents and restricted cash at end of period	459,499	378,673
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	402,461	324,164
Restricted cash included in receivables and other current assets	2,530	0
Restricted cash included in restricted cash and other non-current assets	54,508	54,509
Total cash, cash equivalents and restricted cash	459,499	378,673
Supplemental cash flow disclosures from investing and financing activities:
Purchases of property, plant and equipment included in accounts payable and accrued expenses	732	1,686
Right-of-use assets obtained in exchange for operating lease liabilities	22,049	18,909
Reduction of right of use asset and associated lease liability due to lease reassessment	(9,004)	0
Issuance of unrestricted stock awards to settle accrued employee compensation	$ 14,488	$ 0